Multiple radiations and its effect on biological system – a review on in vitro and in vivo mechanisms DOI Creative Commons
Balasubramanian Deepika, Gopikrishna Agraharam, Agnishwar Girigoswami

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 12, 2025

We are exposed to different types of radiation from natural sources or for biomedical diagnostic and therapeutic purposes at doses times. The dose, duration, number exposures can cause multiple effects both in vivo vitro. Several researchers have explored the ionizing non-ionizing cell lines animal models. Macromolecules, such as DNA, RNA, proteins, primary targets damage lead several diseases, including cancer even death. Chronic low-dose exposure cells alterations gene expression be deleterious fate cells. aim discuss implications radiations on biological systems, how nanotechnology facilitate therapeutics. In this review, we vitro changes that occur due used diagnosis, therapeutics, other means, equipment operators patients being exposed. been discussed separately. also mentioned detail about human-caused accidents Hiroshima Chernobyl article. application facilitating therapy management radioresistance has discussed. radio resistance method improve radiosensitivity mentioned. This review article reflect recent developments various uses field will open up new avenues utilize a more prudent way. role reducing harmful is

Language: Английский

Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis DOI Creative Commons
Md Sadique Hussain, Ehssan Moglad, Muhammad Afzal

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in substantia nigra pars compacta. The precise etiology PD remains unclear, but emerging evidence suggests significant role for disrupted autophagy-a crucial cellular process maintaining protein and organelle integrity.

Language: Английский

Citations

19
Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance DOI Creative Commons
Hanan Elimam, Mohamed Bakr Zaki,

Mai A. Abd‐Elmawla

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Abstract Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate (PCa) is unfavorable since it perilous lethal malignancy. capacity phytochemical nutraceutical chemicals repress oncogenic lncRNAs activate tumor suppressor has garnered significant attention as possible strategy diminish development, proliferation, metastasis, invasion cells. A potential technique treat enhance sensitivity cells existing conventional therapies use phytochemicals anticancer characteristics. Functional studies indicate that modulate drug resistance, stemness, invasion, angiogenesis, proliferation via interactions suppressors oncoproteins. Among them, numerous lncRNAs, such HOTAIR, PlncRNA1, GAS5, MEG3, LincRNA-21, POTEF-AS1, support development PCa through many molecular mechanisms, including modulation regulation various signal pathways like PI3K/Akt, Bax/Caspase 3, P53, MAPK cascade, TGF-β1. Other particular, MALAT-1, CCAT2, DANCR, LncRNA-ATB, ZEB1-AS1, SChLAP1, H19, key players regulating aforementioned processes. Natural substances have shown promising benefits against altering essential signaling pathways. overexpression advanced TNM stage, chemoresistance, reduced LncRNAs possess crucial clinical transitional implications PCa, diagnostic prognostic biomarkers, well medicinal targets. To impede progression beneficial target aberrant long non-coding RNAs using antisense oligonucleotides small interfering (siRNAs). This prevents them from transmitting harmful messages. In summary, several precision medicine approaches may be used rectify dysfunctional lncRNA regulatory circuits, so improving detection eventually facilitating conquest this disease. Due their presence biological fluids tissues, they serve novel biomarkers. Enhancing treatments mitigates resistance chemotherapy radiation.

Language: Английский

Citations

1
Multiple radiations and its effect on biological system – a review on in vitro and in vivo mechanisms DOI Creative Commons
Balasubramanian Deepika, Gopikrishna Agraharam, Agnishwar Girigoswami

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 12, 2025

We are exposed to different types of radiation from natural sources or for biomedical diagnostic and therapeutic purposes at doses times. The dose, duration, number exposures can cause multiple effects both in vivo vitro. Several researchers have explored the ionizing non-ionizing cell lines animal models. Macromolecules, such as DNA, RNA, proteins, primary targets damage lead several diseases, including cancer even death. Chronic low-dose exposure cells alterations gene expression be deleterious fate cells. aim discuss implications radiations on biological systems, how nanotechnology facilitate therapeutics. In this review, we vitro changes that occur due used diagnosis, therapeutics, other means, equipment operators patients being exposed. been discussed separately. also mentioned detail about human-caused accidents Hiroshima Chernobyl article. application facilitating therapy management radioresistance has discussed. radio resistance method improve radiosensitivity mentioned. This review article reflect recent developments various uses field will open up new avenues utilize a more prudent way. role reducing harmful is

Language: Английский

Citations

0