The use of peptides for deciphering the mechanism of EBV, HPV, and HCV invasion of human cells

Published: March 26, 2025

Epstein-Barr virus (EBV), human papillomavirus (HPV), and hepatitis C (HCV) are significant pathogens associated with various diseases, employing complex molecular mechanisms for cellular entry immune evasion. Peptide-based research, using more than 700 synthetic peptides, has deciphered some of the interactions between viral proteins host cell receptors, offering promising diagnostics therapeutic strategies. In EBV, binding peptides have been identified: 11382, 11389, 11416 derived from gp350/220; 11435, 11436, 11438 gp85 [glycoprotein H (gH)]; 11521 BNRF1/p140. Most these peptide sequences surface-exposed part contact regions making them candidates strategies aimed at inhibiting EBV invasion cells. Peptide 11382 is target neutralizing antibody 72A1; induce interleukin-6 production; 11435 binds to integrin αvβ6, triggers a cytokine storm. HPV L1 protein, major component capsid, 18283 18294 identified as epithelial cell-binding located on surface. Parts recognized by anti-HPV antibodies. These two along 18301, potential biomarkers infection because they antibodies elicited during natural infection, suitable targets serological detection. envelope E1 E2 HCV, five hepatocyte- CD81-positive identified. The contain linear B-cell epitopes antibodies, used develop tests determining HCV infection. approaches can lead innovative prevention, diagnosis, treatment diseases. Additionally, their be modulate response generate tools cancer theragnostic.

Language: Английский

Viral Infections and the Glutathione Peroxidase Family: Mechanisms of Disease Development

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

The glutathione peroxidase (GPx) family is recognized for its essential function in maintaining cellular redox balance and countering the overproduction of reactive oxygen species (ROS), a process intricately linked to progression various diseases including those spurred by viral infections. modulation GPx activity viruses presents critical juncture disease pathogenesis, influencing responses trajectory infection-induced diseases.

Language: Английский