Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: recent insights and potential clinical applications

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 1 - 21

Published: Dec. 3, 2024

Lung cancer (LC) is one of the most common causes cancer-related death worldwide. It has been demonstrated that prognosis current drug treatments affected by a variety factors, including late stage, tumor recurrence, inaccessibility to appropriate treatments, and, importantly, chemotherapy resistance. Non-coding RNAs (ncRNAs) contribute development, with some acting as suppressors and others oncogenes. The phosphoinositide 3-kinase (PI3Ks)/AKT serine/threonine kinase pathway important targets ncRNAs in cancer, which widely applied modulate cell cycle biological processes, growth, mobility survival, metabolic activity, protein production. Discovering biology ncRNA-PI3K/AKT signaling may lead advances diagnosis treatment. As result, we investigated expression role PI3K/AKT-related clinical characteristics lung well their functions potential biomarkers diagnosis, prognosis,

Language: Английский

Development and validation of a prognostic and drug sensitivity model for gastric cancer utilizing telomere-related genes

Translational Oncology, Journal Year: 2024, Volume and Issue: 52, P. 102232 - 102232

Published: Dec. 7, 2024

Language: Английский

Unraveling the mechanisms of glioblastoma’s resistance: investigating the influence of tumor suppressor p53 and non-coding RNAs

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Language: Английский