Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy DOI Creative Commons

Ryan Conesa-Bakkali,

Macarena Morillo‐Huesca, Jonathan Martínez‐Fábregas

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 68 - 68

Published: Jan. 7, 2025

Lysosomes are subcellular compartments characterised by an acidic pH, containing ample variety of acid hydrolases involved in the recycling biopolymers. Among these hydrolases, lysosomal proteases have merely been considered as end-destination responsible for digestion waste proteins, trafficked to compartment through autophagy and endocytosis. However, recent reports started unravel specific roles regulation initially unexpected biological processes, both under physiological pathological conditions. Furthermore, some no longer restricted compartment, more novel non-canonical, extralysosomal targets being identified. Currently, accepted play key functions extracellular milieu, attached plasma membrane even cytosolic nuclear cell. Under conditions, proteases, activities, linked cell differentiation, gene expression, division. cancer, mostly their activities cytosol nuclei cells. In this review, we aim provide a comprehensive summary our current knowledge about extralysosomal, non-canonical with particular interest that could potentially offer new opportunities clinical intervention.

Language: Английский

Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy DOI Creative Commons

Ryan Conesa-Bakkali,

Macarena Morillo‐Huesca, Jonathan Martínez‐Fábregas

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 68 - 68

Published: Jan. 7, 2025

Lysosomes are subcellular compartments characterised by an acidic pH, containing ample variety of acid hydrolases involved in the recycling biopolymers. Among these hydrolases, lysosomal proteases have merely been considered as end-destination responsible for digestion waste proteins, trafficked to compartment through autophagy and endocytosis. However, recent reports started unravel specific roles regulation initially unexpected biological processes, both under physiological pathological conditions. Furthermore, some no longer restricted compartment, more novel non-canonical, extralysosomal targets being identified. Currently, accepted play key functions extracellular milieu, attached plasma membrane even cytosolic nuclear cell. Under conditions, proteases, activities, linked cell differentiation, gene expression, division. cancer, mostly their activities cytosol nuclei cells. In this review, we aim provide a comprehensive summary our current knowledge about extralysosomal, non-canonical with particular interest that could potentially offer new opportunities clinical intervention.

Language: Английский

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