Targeting KRAS in gynecological malignancies DOI Creative Commons
Yuanyuan Peng, Qing Yang

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(19)

Published: Oct. 8, 2024

Abstract Cervical, endometrial, and ovarian cancers stand prominently as the leading gynecological malignancies of female reproductive system. The conventional therapeutic modalities for have predominantly encompassed surgery, chemotherapy, radiotherapy. However, efficacy these approaches remains limited in cases relapse or drug resistance. KRAS is one most frequently mutated oncogenes human cancers. gene encodes a small guanosine triphosphatase protein that acts molecular switch crucial intracellular signaling pathways. mutations are deeply involved occurrence development malignancies. present review aims to expound upon role oncogenic biomarker, elucidating various under investigation targeting pathway tumors.

Language: Английский

Exploring extracellular RNA as drivers of chemotherapy resistance in cancer DOI

Yumna Khan,

Md Sadique Hussain, Prasanna Srinivasan Ramalingam

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 21, 2025

Language: Английский

Citations

2
Exosomal ncRNAs in liquid biopsies for lung cancer DOI
Md Sadique Hussain, Gaurav Gupta, Nehmat Ghaboura

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 119983 - 119983

Published: Oct. 3, 2024

Language: Английский

Citations

15
piRNAs in leukemogenesis: Mechanisms, biomarkers, and therapeutic implications DOI
Gaurav Gupta, Muhammad Afzal, Ahsas Goyal

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120220 - 120220

Published: March 1, 2025

Language: Английский

Citations

0
Macrophage-derived lncRNAs in cancer: regulators of tumor progression and therapeutic targets DOI
Muath Suliman, Raed Obaid Saleh,

M Chandra

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 6, 2025

Language: Английский

Citations

0
Innovative anti-aging strategies targeting WNT pathway epigenetics for gut function DOI

Yumna Khan,

Ajay Singh Bisht, Sumel Ashique

et al.

Human Gene, Journal Year: 2025, Volume and Issue: 44, P. 201397 - 201397

Published: March 5, 2025

Language: Английский

Citations

0
Harnessing Artificial Intelligence for Precision Diagnosis and Treatment of Triple Negative Breast Cancer DOI
Md Sadique Hussain, Prasanna Srinivasan Ramalingam,

Gayathri Chellasamy

et al.

Clinical Breast Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Targeting USP47 enhances the efficacy of KRAS inhibitor in KRASG12C mutated non-small cell lung cancer by controlling deubiquitination of c-Myc DOI Creative Commons

H. Y. Shin,

S. O. Hwang,

Jeong Hyun Jeong

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107722 - 107722

Published: April 1, 2025

Language: Английский

Citations

0
Role of long non-coding RNAs in neurofibromatosis and Schwannomatosis: pathogenesis and therapeutic potential DOI
Md Sadique Hussain, Somya Sharma,

Alka Kumari

et al.

Epigenomics, Journal Year: 2024, Volume and Issue: 16(23-24), P. 1453 - 1464

Published: Nov. 27, 2024

Neurofibromatosis (NF) is identified as genetic disorder characterized by multiple tumors on nerve tissues. NF1 the most prevalent form, neurofibromas and skin changes. neurofibromatosis disorder, distinct from rarer NF2 schwannomatosis (SWN) conditions. NF2, including NF2-related SWN (NF2-SWN), predominantly involves schwannoma formation differs

Language: Английский

Citations

2
Liquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics DOI

Ashok Kumar Balaraman,

Ehssan Moglad, Muhammad Afzal

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120105 - 120105

Published: Dec. 1, 2024

Language: Английский

Citations

1
Targeting KRAS in gynecological malignancies DOI Creative Commons
Yuanyuan Peng, Qing Yang

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(19)

Published: Oct. 8, 2024

Abstract Cervical, endometrial, and ovarian cancers stand prominently as the leading gynecological malignancies of female reproductive system. The conventional therapeutic modalities for have predominantly encompassed surgery, chemotherapy, radiotherapy. However, efficacy these approaches remains limited in cases relapse or drug resistance. KRAS is one most frequently mutated oncogenes human cancers. gene encodes a small guanosine triphosphatase protein that acts molecular switch crucial intracellular signaling pathways. mutations are deeply involved occurrence development malignancies. present review aims to expound upon role oncogenic biomarker, elucidating various under investigation targeting pathway tumors.

Language: Английский

Citations

0