Imbalance between default mode and sensorimotor connectivity is associated with perseverative thinking in obsessive-compulsive disorder

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Jan. 12, 2022

Abstract Obsessive-compulsive disorder (OCD) is highly heterogeneous. Although perseverative negative thinking (PT) a feature of OCD, little known about its neural mechanisms or relationship to clinical heterogeneity in the disorder. In sample 85 OCD patients, we investigated relationships between self-reported PT, symptom subtypes, and resting-state functional connectivity measures local global connectivity. Results indicated that PT scores were variable within sample, with greater relating higher severity “unacceptable thoughts” dimension. was positively related subgenual anterior cingulate cortex (ACC), pregenual ACC, temporal poles—areas are part of, closely linked to, default mode network (DMN)—and negatively sensorimotor cortex. While majority patients showed strengths compared DMN regions, had less an imbalance than those lower scores, healthy controls exhibiting intermediate pattern. Clinically, this both “symmetry/not-just-right-experiences” dimensions, but opposite directions. These effects remained significant after accounting for variance psychiatric comorbidity medication use no found data indicate variability OCD. Future work may wish target circuity when developing personalized interventions these symptoms.

Language: Английский

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Depression, stress and regional cerebral blood flow

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2023, Volume and Issue: 43(5), P. 791 - 800

Published: Jan. 6, 2023

Decreased cerebral blood flow (CBF) may be an important mechanism associated with depression. In this study we aimed to determine if the association of CBF and depression is dependent on current level or tendency experience over time (trait depression), influenced by depression-related factors such as stressful life experiences antidepressant medication use. was measured in 254 participants from Amish Connectome Project (age 18–76, 99 men 154 women) using arterial spin labeling. All underwent assessment symptoms Beck Depression Inventory Maryland Trait State scales. Individuals diagnosed a unipolar depressive disorder had significantly lower average gray matter compared individuals no history that remission at study. CBF, associations strongest cingulate gyrus frontal white matter. Use more were also CBF. Resting specific brain regions trait depression, events, use, provide valuable biomarker for further studies.

Language: Английский

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Effects of non‐invasive vagus nerve stimulation on cognitive and autonomic correlates of perseverative cognition

Psychophysiology, Journal Year: 2023, Volume and Issue: 60(6)

Published: Jan. 22, 2023

Abstract Perseverative cognitions can provoke psychophysiological stress in the absence of an actual stressor and are considered important transdiagnostic vulnerability factors for several (mental) health issues. These stress‐related cognitive processes reflected by both (assessed self‐reports) autonomic inflexibility heart rate variability; HRV), with a key role attributed to vagus nerve. Interestingly, modulation afferent branches be achieved transcutaneous auricular nerve stimulation (taVNS), non‐invasive technique that employs low‐intensity electrical current applied ear. In sample healthy individuals, we investigated effects taVNS left concha, compared sham (earlobe) stimulation, on correlates perseverative cognition following psychosocial task. significantly reduced rigidity, subjective thinking after stress. Although there were no direct cognition, individual differences affected HRV. Specifically, more during task (i.e., HRV) was associated increases afterward condition, but not active condition. Additional exploratory analyses revealed significant moderation intensity. Overall, study findings endorse association between functioning.

Language: Английский

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Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 340, P. 843 - 854

Published: Aug. 13, 2023

Language: Английский

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A three-dimensional model of neural activity and phenomenal-behavioral patterns

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(3), P. 639 - 652

Published: Dec. 19, 2023

Language: Английский

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