Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data‐Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders

Neuropsychopharmacology Reports, Journal Year: 2025, Volume and Issue: 45(1)

Published: Feb. 26, 2025

ABSTRACT One of the challenges in diagnosing psychiatric disorders is that results biological and neuroscience research are not reflected diagnostic criteria. Thus, data‐driven analyses incorporating cross‐disease perspectives, regardless category, have recently been proposed. A clustering study based on subcortical volumes 5604 subjects classified into four brain biotypes associated with cognitive/social functioning. Among identified controls patients schizophrenia, bipolar disorder, major depressive autism spectrum other disorders, we further analyzed biotype 1 subjects, those an extremely small limbic region, for clinical utility. We found representative feature enlarged lateral ventricles. An ventricle, defined by average z ‐score left right ventricle > 3, had a sensitivity 99.1% specificity 98.1% discriminating 1. However, presence was sufficient to classify patient subgroups, as 1% also Reclassification ventricles according cognitive impairment resulted stratified subgroup included high proportion schizophrenia diagnoses, electroencephalography abnormalities, rare pathological genetic copy number variations. Data‐driven analysis neuroimaging data revealed subgroups impairment. This could be new candidate disorders. concept strategy may useful identifying biologically future.

Language: Английский

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Antidepressant treatment in complex clinical pictures

International Clinical Psychopharmacology, Journal Year: 2025, Volume and Issue: 40(3), P. 123 - 126

Published: March 26, 2025

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