Effectiveness of Hydrated Sodium Calcium Aluminosilicates and Discarded Date Pits as Dietary Adsorbents for Aflatoxin B1 in Enhancing Broiler Chicken Productive Performance, Hepatic Function, and Intestinal Health DOI Creative Commons
Alaeldein M. Abudabos, Riyadh S. Aljumaah, Abdulaziz A. Al-Abdullatif

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(14), P. 2124 - 2124

Published: July 21, 2024

The research aimed to evaluate how effective hydrated sodium calcium aluminosilicates (HSCASs) and discarded date pits (DDPs) are as dietary adsorbents for aflatoxin B1 (AFB1) in enhancing the performance health of broiler chickens aged 16 30 days. A total 240 Ross 308 straight-run broilers were randomly allocated into four groups, each with 10 replicates: a control diet, diet 1000 ppb AFB1, an AFB1-contaminated 0.5% HSCAS, 4% DDP. Incorporating HSCASs or DDPs resulted significant improvements across various parameters, involving increased body weight, improved feed conversion ratio, higher dressing percentage, decreased relative weights kidney spleen, elevated serum levels protein, globulin, glucose, reduced alanine aminotransferase activity, heightened hepatic protein concentration glutathione peroxidase along diminished malondialdehyde content glutamic oxaloacetic transaminase activity. Moreover, both supplements led ileal villus height surface area, enhanced apparent nitrogen-corrected metabolizable energy digestibility, AFB1 residues liver kidney. inclusion significantly raised albumin concentration, lowered alkaline phosphatase antioxidant capacity level, augmented width. Conversely, addition crude digestibility. In conclusion, diets can mitigate toxic effects on chickens, exhibiting additional advantages optimizing function gut morphology.

Language: Английский

Aflatoxin B1: Challenges and Strategies for the Intestinal Microbiota and Intestinal Health of Monogastric Animals DOI Creative Commons
Hyunjun Choi, Yesid Garavito-Duarte, Alexa R. Gormley

et al.

Toxins, Journal Year: 2025, Volume and Issue: 17(1), P. 43 - 43

Published: Jan. 17, 2025

The objective of this review is to investigate the impacts aflatoxins, particularly aflatoxin B1 (AFB1), on intestinal microbiota, health, and growth performance in monogastric animals, primarily chickens pigs, as well dietary interventions mitigate these effects. Aflatoxin contamination feeds disrupts induces immune responses oxidative damage, increases antioxidant activity, impairs jejunal cell viability, barrier function, morphology small intestine. These changes compromise nutrient digestion reduce animals. negative impact AFB1 % change average daily gain (ΔADG) pigs was estimated based meta-analysis: ΔADG (%)chicken = -0.13 × intake per body weight (ng/g·d) (%)pig -0.74 (µg/kg·d), indicating that increasing linearly reduces To harmful AFB1, various strategies have been effective. Mycotoxin-detoxifying agents include mycotoxin-adsorbing agents, such clay yeast wall compounds, binding mycotoxin-biotransforming specific strains Bacillus subtilis mycotoxin-degrading enzyme, degrading into non-toxic metabolites D1. Multiple mycotoxin-detoxifying are often combined used together improve health fed AFB1-contaminated feeds. In summary, negatively stress, morphology, intestine, leading reduced performance. Supplementing multi-component could effectively adsorb degrade co-contaminated with other mycotoxins prior its absorption preventing pigs.

Language: Английский

Citations

3
Mechanisms by which microbial enzymes degrade four mycotoxins and application in animal production: A review DOI Creative Commons

Huiying Sun,

Ziqi He,

Dongwei Xiong

et al.

Animal nutrition, Journal Year: 2023, Volume and Issue: 15, P. 256 - 274

Published: Oct. 4, 2023

Mycotoxins are toxic compounds that pose a serious threat to animal health and food safety. Therefore, there is an urgent need for safe efficient methods of detoxifying mycotoxins. As biotechnology has continued develop, involving biological enzymes have shown great promise. Biological enzymatic methods, which can fundamentally destroy the structures mycotoxins produce degradation products whose toxicity greatly reduced, generally more specific, efficient, environmentally friendly. Mycotoxin-degrading thus facilitate effective detoxification gives them huge advantage over other methods. This article summarizes newly discovered degrading degrade four common (aflatoxins, zearalenone, deoxynivalenol, ochratoxin A) in past five years, reveals mechanism on mycotoxins, as well their positive effects production. review will provide theoretical basis treatment by using enzyme technology.

Language: Английский

Citations

26
AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures DOI Open Access

Agnieszka Pożarska,

Krzysztof Karpiesiuk, W. Kozera

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5305 - 5305

Published: May 13, 2024

The current review aims to outline and summarize the latest research on aflatoxin, with studies describing natural, herbal chemical compound applications in animal (pig) models vitro cellular studies. Aflatoxin, a carcinogenic toxin metabolite, is produced by Aspergillus flavus humid environments, posing threat human health crop production. treatment involves prevention of exposure aflatoxin counteracting its harmful toxic effects, enabling survival an antidote for aflatoxin. To prospects influence forage farm production, food processing. application remedies treat undergoing development pinpoint biochemical pathways responsible effects transmission actions treatment. underline environmental stress meat dairy products; describe clinical syndromes associated aflatoxicosis that are counteracted proposed preventive interventions. understand how improve animals feed conditions.

Language: Английский

Citations

8
Aflatoxin B1 Impairs Bone Mineralization in Broiler Chickens DOI Creative Commons
Deependra Paneru,

Milan Kumar Sharma,

Hanyi Shi

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(2), P. 78 - 78

Published: Feb. 2, 2024

Aflatoxin B1 (AFB1), a ubiquitous mycotoxin in corn-based animal feed, particularly tropical regions, impairs liver function, induces oxidative stress and disrupts cellular pathways, potentially worsening bone health modern broilers. A 19-day experiment was conducted to investigate the effects of feeding increasing levels AFB1-contaminated feed (<2, 75–80, 150, 230–260 520–560 ppb) on mineralization markers broilers (n = 360). While growth performance remained unaffected up Day 19, significant reductions tibial ash content were observed at exceeding 260 ppb. Micro-computed tomography results showed that AFB1 560 ppb significantly decreased trabecular mineral density, with tendency for reduced connectivity density femur metaphysis. Moreover, above 230 volume tissue cortical femur. Even 75 ppb, exposure downregulated jejunal mRNA expressions vitamin D receptor calcium phosphorus transporters. It can be concluded higher than negatively affects by impairing via disruption homeostasis, contributing issues

Language: Английский

Citations

5
Mycotoxicological Assessment of Broiler Compound Feed: A Multi-Year Analysis of Five Mycotoxins in a Romanian Feed Mill DOI Creative Commons
Dragoș Mihai Lăpușneanu, Silvia-Ioana Petrescu, Cristina-Gabriela Radu-Rusu

et al.

Agriculture, Journal Year: 2025, Volume and Issue: 15(1), P. 84 - 84

Published: Jan. 2, 2025

Mycotoxins are secondary metabolites of filamentous fungi that cause massive agricultural losses worldwide and constitute a significant health problem for humans animals. The aim this five-year study was to investigate the contamination compound feed broiler chickens at all stages (starter, grower finisher) from mill in Romania with mycotoxins such as total aflatoxins (AFT), deoxynivalenol (DON), fumonisins (FUMs), ochratoxin A (OTA) zearalenone (ZEN). AFT detected 49.3–72.2% samples concentrations ranging 0.01 5.2 µg/kg. DON 77.6–98.9% samples, maximum 330 1740 FUM ranged 42.7% 87.2%, levels between 460 1400 OTA present 44.2–87.9% reaching 21.4 ZEN consistently elevated feeding stages, being 86.5–97.4% 89.4 Mycotoxin co-occurrence common most combination four occurring 38.51% samples. Samples were collected storage bunkers, homogenised analysed certified laboratories, sampling procedures varying according batch size ensure representativeness. Investigation transfer into animal products combined effects on health, including potential synergistic or antagonistic interactions, is particularly relevant. This emphasises essential role comprehensive continuous monitoring protecting food safety.

Language: Английский

Citations

0
Research Note: Protective effects of compound mycotoxin detoxifier in broiler chicken fed aflatoxins-contaminated diets DOI Creative Commons

Kourosh Gholami Ahmadabadi,

Masoud Rahimi,

Hamid Raei

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(2), P. 104802 - 104802

Published: Jan. 10, 2025

This study was planned and executed to investigate the effects of two levels compound toxin binder (CTB) on growth performance, serum biochemistry, antioxidant status, intestinal morphology, ileal selected microflora population in broiler chickens. A total 240 one-day-old Ross 308 chickens were divided into four treatments six replicates (10 per replicate). Experimental groups included; 1, negative control (NC; no aflatoxins (AFs) additives); 2, positive (PC; 490 µg/kg AFs); 3, low (LCTB), PC + 1 g/kg available CTB (Navacidox); 4, high (HCTB), 2 Navacidox. Increasing body weight gain (BWG) following feeding HCTB found compared (P < 0.05). The highest feed intake (FI) observed NC Feeding broilers with AFs decreased villus height, width, crypt depth increasing lactic acid bacteria recorded Among biochemistry parameters, protein, LDL, uric LCTB Lower concentrations ALP, LDH, AST, ALT Although capacity, GPx, SOD activities not affected by > 0.05), lowest catalase In conclusion, impaired morphology. However, inclusion AFs-contaminated diets effectively mitigated harmful AFs.

Language: Английский

Citations

0
Strategies for Decontamination and Alleviation of Mycotoxins for Sustainable Poultry Farming – A Review DOI Open Access
Youssef A. Attia, Tarek A. Ebeid, Manal E. Shafi

et al.

Annals of Animal Science, Journal Year: 2025, Volume and Issue: 25(1), P. 139 - 157

Published: Jan. 1, 2025

Abstract Mycotoxins including aflatoxins (AF), zearalenone (ZEN), ochratoxin A (OTA), fumonisins (FUM), trichothecenes (TCN), deoxynivalenol (DON), and T-2 toxin had negative influences on poultry productivity causing a depression in performance, product quality, antioxidative properties, immunity, health status, economic value sustainability of production. The liver kidney are the organs most affected by dysfunction genetic damage (carcinogenicity, mutagenicity, teratogenicity). Chemical physical approaches, washing extracting solvents, heat inactivation, irradiation, chemical agents, used to detoxify mycotoxins feedstuff. Also, dietary addition adsorbents (zeolites, bentonites, hydrated sodium calcium aluminosilicate, glucomannan, etc.) is strategy extensively Additionally, several feed additives, microorganisms, phytogenic natural anti-oxidants, can reduce impacts achieve promising results industry. However, efficacies these various strategies different, showing distinct variations, some limited effectiveness. Moreover, minimum time required induce complete recovery from lacking literature, as four weeks after removal, there still adverse effects performance physiological traits. This review focuses impact different for eliminating or mitigating their immunological traits means. In addition, mycotoxicosis effect molecular pathways prevention alleviation additives concerning have been evaluated.

Language: Английский

Citations

0
Protective Effects of Propolis Supplementation on Aflatoxin B1‐Induced Oxidative Stress, Antioxidant Status, Intestinal Barrier Damage, and Gut Microbiota in Rats DOI Creative Commons
Sevtap KÜÇÜKCANKURTARAN, Mehtap Ünlü Söğüt, Neslihan Öner

et al.

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

ABSTRACT Aflatoxin B1 (AFB1) is common in the diets of humans and animals often leads to adverse health effects. Propolis, with its strong antioxidant activity, can reduce oxidative stress modulate gut microbiota composition. However, underlying mechanism by which propolis alleviates AFB1‐induced intestinal barrier damage remains unclear. This study was designed investigate protective effects oral supplementation AFB1‐exposed rats. Thirty‐two male Sprague‐Dawley rats were divided into four groups: control, AFB1, propolis, AFB1+propolis. After 4 weeks, serum markers examined, analyzed 16S rRNA sequencing. Intestinal sections processed Hematoxylin & Eosin staining, expression level tight junction proteins assessed immunostaining. Propolis tended decrease stress, it also restructured preventing a relative abundances Lactobacillus , Roseburia Phascolarctobacterium . restored permeability impaired AFB1 ameliorating morphological increasing levels proteins. may contribute modulation alleviating improving

Language: Английский

Citations

0
Influence of phytochemicals on growth performance, gut morphology and ceca microbiome in broilers fed aflatoxin-contaminated diet and raised under high stocking density and heat stress DOI Creative Commons

Kittisak Insawake,

Thaweesak Songserm,

Ornprapun Songserm

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105293 - 105293

Published: May 1, 2025

Language: Английский

Citations

0
Compound probiotics starter: A solution for aflatoxin B1 reduction and meat quality improvement in fermented chicken jerky DOI Creative Commons
Hongwei Guo, Jingyan Chen, H Qiu

et al.

Food Control, Journal Year: 2024, Volume and Issue: 165, P. 110601 - 110601

Published: May 27, 2024

This study investigated the effects of compound probiotics (CP) as starter cultures to reduce AFB1 residues and improve safety quality chicken jerky. First, Enterococcus faecalis, Candida utilis, Lactobacillus casein, Bacillus subtilis were subjected single strain fermentation experiments. Then, a three-factor, three-level response surface methodology design was used select CP based on degradation histamine content. The optimal included casein at initial viable counts 3.0 × 108, 109 CFU/mL respectively, then mixed volume ratio 1:1:1. Each AFB1-contaminated strip fermented with 0.15 mL 30 °C for 40 h dried. contents reduced by 90.18% 9.74% in jerky, compared unfermented jerky (P < 0.05). Amino acid analysis showed lower serine histidine higher cysteine content 16S rRNA sequencing unveiled reduction absolute abundance Staphylococcus saprophyticus. According metabolomics proteomics, inhibited methionine metabolism increased lactic alanine accumulation through pathways (KEGG map ID: 00270), thereby maintaining low pH improving flavor/safety. results thus confirmed that C. L. B. are potential meat product starters.

Language: Английский

Citations

3