Ameliorative avian gut environment and bird productivity through the application of safe antibiotics alternatives: a comprehensive review

Poultry Science, Journal Year: 2023, Volume and Issue: 102(9), P. 102840 - 102840

Published: June 13, 2023

The avian digestive tract is an important system for converting ingested food into the nutrients their bodies need maintenance, growth, and reproduction (meat, table eggs, fertile eggs). Therefore, preserving integrity crucial to bird health productivity. As alternative antibiotics, world has recently turned use of natural products enhance development, intestinal health, production. primary goal this review explain various characteristics how its performance with natural, safe feed additives such as exogenous enzymes, organic acids, photogenic products, amino prebiotics, probiotics, synbiotics, herbal extracts. In conclusion, composition gut microbiome can be influenced by a number circumstances, consequences productivity birds. To better understand connection between pathogens, variety therapies available, gut, additional research needs carried out.

Language: Английский

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Concord grape (Vitis labrusca ‘Concord’) pomace extract impacts dextran sulfate sodium-induced inflammation in ovo (Gallus gallus)

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106840 - 106840

Published: April 28, 2025

Language: Английский

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Anti-Inflammatory Effects of a Novel Acetonitrile–Water Extract of Lens Culinaris against LPS-Induced Damage in Caco-2 Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3802 - 3802

Published: March 28, 2024

Natural compounds like flavonoids preserve intestinal mucosal integrity through their antioxidant, anti-inflammatory, and antimicrobial properties. Additionally, some show prebiotic abilities, promoting the growth activity of beneficial gut bacteria. This study investigates protective impact Lens culinaris extract (LE), which is abundant in flavonoids, on during LPS-induced inflammation. Using Caco-2 cells as a model for barrier, found that LE did not affect cell viability but played cytoprotective role presence LPS. improved transepithelial electrical resistance (TEER) tight junction (TJ) protein levels, are crucial barrier integrity. It also countered upregulation pro-inflammatory genes TRPA1 TRPV1 induced by LPS reduced markers TNF-α, NF-κB, IL-1β, IL-8. Moreover, reversed AQP8 TLR-4 expression. These findings emphasize potential natural to regulate reduce inflammation's harmful effects cells. More research required understand mechanisms explore therapeutic applications, especially gastrointestinal inflammatory conditions.

Language: Английский

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Effects of a Combined Chinese Herbal Medicine on Growth Performance, Intestinal Barrier Function, Immune Response, and Cecal Microflora in Broilers Infected with Salmonella enteritidis

Animals, Journal Year: 2024, Volume and Issue: 14(18), P. 2670 - 2670

Published: Sept. 13, 2024

This study investigated the effects of CCHM in drinking water on broilers infected with

Language: Английский

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Combination of organic acids benzoate, butyrate, caprylate, and sorbate provides a novel antibiotics-independent treatment option in the combat of acute campylobacteriosis

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: March 15, 2023

The food-borne Gram-negative bacterial pathogen Campylobacter jejuni may cause the acute enterocolitis syndrome campylobacteriosis in infected humans. Given that human C. infections are rising globally which hold also true for resistance rates against antibiotic compounds such as macrolides and fluoroquinolones frequently prescribed treatment of severe infectious enteritis, novel antibiotics-independent therapeutic strategies needed. Distinct organic acids well known their health-beneficial including anti-microbial immunomodulatory properties. In our present study, we investigated potential pathogen-lowering anti-inflammatory effects benzoic acid, butyric caprylic sorbic acid either alone or combination during murine campylobacteriosis.Therefore, secondary abiotic IL-10-/- mice were perorally with strain 81-176 subjected to a 4-day-course respective treatment.On day 6 post-infection, from cohort displayed slightly lower loads duodenum, but neither stomach, ileum nor large intestine. Remarkably, clinical outcome induced was significantly improved after combined when compared placebo control group. support, combinatory dampened both, macroscopic microscopic inflammatory sequelae infection indicated by less colonic shrinkage pronounced histopathological apoptotic epithelial cell changes colon on post-infection. Furthermore, exhibited numbers innate adaptive immune cells neutrophilic granulocytes, macrophages, monocytes, T lymphocytes mucosa lamina propria, respectively, held pro-inflammatory cytokine secretion intestines mesenteric lymph nodes. Notably, not restricted intestinal tract, could be observed systemically given mediator concentrations comparable basal values. conclusion, vivo study provides first evidence an oral application distinct exhibits hence, constitutes promising strategy combat campylobacteriosis.

Language: Английский

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Paneth cells in farm animals: current status and future direction

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 15, 2023

Abstract A healthy intestine plays an important role in the growth and development of farm animals. In small intestine, Paneth cells are well known for their regulation intestinal microbiota stem (ISCs). Although there has been a lot studies reviews on human murine under homeostasis or disorders, little is about Most animals possess as identified by various staining methods, livestock species exhibit noticeable differences cell shape, granule number, distribution. antimicrobial peptides (AMPs) susceptible to multiple factors such dietary nutrients infection. Thus, comprehensive understanding different will contribute improvement health. This review first summarizes current status pig, cattle, sheep, horse, chicken rabbit, points out future directions investigation reviewed

Language: Английский

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Potential benefits of advanced chelate-based trace minerals in improving bone mineralization, antioxidant status, immunity, and gene expression modulation in heat-stressed broilers

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0311083 - e0311083

Published: Oct. 2, 2024

Organic sources of trace minerals (TM) in broiler diets are more bioavailable and stable than inorganic sources, making them particularly beneficial during challenging periods such as heat stress (HS) conditions. A 42-d study investigated the effects using advanced chelate technology-based TM (ACTM) or adding varying amounts ACTM to HS The involved 672 male chickens 7 treatment groups, including a thermoneutral control (TNC) group six treatments. There were 8 replicate pens per 12 birds replicate. treatments included exposed cyclic environment (34°C) for h follows: HSC, which consisted same basal diet with recommended ITM levels; ACTM50 ACTM100, replaced 50% 100% instead ITM; ITM+ACTM12.5 ITM+ACTM25, extra at 12.5% 25%, respectively; ITM125, used 125% levels diet. Compared HSC treatment, TNC, ITM+ACTM25 resulted increased ( P < 0.05) body weight; tibia ash, phosphorus, iron, manganese contents; secondary antibody titers; serum TAC SOD values but decreased MDA concentrations expression hepatic genes IL-1β, IL-6, INF-γ. TNC ACTM100 groups also showed greater feed efficiency, length, zinc content, SOD1 exhibited reduced NF-kB expression. Significant increases primary anti-NDV titers, GPx1 activity, Nrf2 gene detected ITM+ACTM12.5, groups. In conclusion, findings suggest that replacing diets, especially 25% higher dose, can effectively protect broilers from by promoting growth, reducing inflammation, increasing antioxidant proteins.

Language: Английский

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Establishment and characterization of an SV40 immortalized chicken intestinal epithelial cell line

Poultry Science, Journal Year: 2023, Volume and Issue: 102(10), P. 102864 - 102864

Published: July 14, 2023

Primary chicken intestinal epithelial cells or 3D enteroids are a powerful tool to study the different biological mechanisms that occur in intestine. Unfortunately, they not ideal for large-scale screening long-term studies due their short lifespan. Moreover, require expensive culture media, coatings, usage of live embryos each isolation. The aim this was establish and characterize an immortalized cell line help host-pathogen interactions poultry. This established by transducing into primary enterocytes SV40 large-T antigen through lentiviral vector. transduced grew without changes up 40 passages maintaining, after differentiation phase 48 h with epidermal growth factor, properties mature such as alkaline phosphatase activity tight junction formation. Immortalized were able generate cytokine response during inflammatory challenge, showed be susceptible Eimeria tenella sporozoites invasion proper immune parasitic lipopolysaccharide (Escherichia coli) stimulation. could cost-effective easy-to-maintain model all public health, food safety, research pharmaceutical laboratories interactions, foodborne pathogens, feed science vitro.

Language: Английский

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Effects of benzoic acid or benzocal-50 supplementation on growth performance and intestinal health in mixed-sex Ross 308 chickens under a high stocking density

The Journal of Applied Poultry Research, Journal Year: 2024, Volume and Issue: 33(3), P. 100454 - 100454

Published: June 28, 2024

An experiment was conducted to evaluate the impacts of dietary supplementation with unprotected benzoic acid (BA) or benzocal-50 (protected BA) on growth performance and intestinal health in mixed-sex Ross 308 broilers under a high stocking density. A total 768 one-d-old chickens (BW: 43.52 ± 0.68 g) were randomly allotted 4 treatments (6 replicates 32 each): 1) basal diet (NC); 2) 30 mg/kg avilamycin (PC); 3) 1,000 BA (PBA); 4) (330, 330, 300 starter (d 1-14), grower 15–28), finisher 29–41) phases) (EBA). The normal density during phase for is 25.0 kg BW/m², but this study used 29.0 BW/m² results revealed an increase ADG EBA treatment compared PBA d 8 14 (P < 0.05). In 15–28) phases, fed exhibited lower digesta pH values than those NC Moreover, displayed greater AID dry matter crude protein PC resulted upregulation sodium-dependent neutral amino transporter peptide (PEPT1) mRNA expressions jejunum 14, increased sodium-glucose transport 1 expression 28, enhanced PEPT1 41, when improved cadherin 28 Overall, supplementing led decrease gut pH, contributing reduced fecal score overall enhancement barrier function.

Language: Английский

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Dietary supplementation of microencapsulated botanicals and organic acids enhances the expression and function of intestine epithelial digestive enzymes and nutrient transporters in broiler chickens

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104237 - 104237

Published: Aug. 22, 2024

Organic acids and botanicals have shown protective effects on gut barrier against inflammation in broilers. However, their intestinal digestive enzymes nutrients transporters expression functions not been fully studied. The objective of this study was to understand how a microencapsulated blend organic affected enzyme activities nutrient A total 288 birds were assigned commercial control diet or supplemented with 500 g/MT (metric ton) the additive. Growth performance recorded weekly. At d 21 42, jejunum ileum isolated for (maltase, sucrase, aminopeptidase) transporter (SGLT1, GLUT2, GLUT1, EAAT3, B

Language: Английский

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