4D DIA proteomic analysis of gender and age influences on meat quality and flavor in Hetian white sheep DOI
Jing Wang, Hengxun Lin, Quanfeng Wang

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141851 - 141851

Published: Oct. 30, 2024

Language: Английский

Multi-Omics Insights into Regulatory Mechanisms Underlying Differential Deposition of Intramuscular and Abdominal Fat in Chickens DOI Creative Commons
Yuxin Xing,

Chenglin Ma,

Hong-Bo Guan

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 134 - 134

Published: Jan. 15, 2025

Excessive abdominal fat deposition in chickens disadvantages feed conversion, meat production, and reproductive performance. Intramuscular contributes to texture, tenderness, flavor, serving as a vital indicator of overall quality. Therefore, comprehensive analysis the regulatory mechanisms governing differential versus intramuscular is essential breeding higher-quality with ideal distribution. This review systematically summarizes underlying traits at chromatin, genomic, transcriptional, post-transcriptional, translational, epigenetic-modification scales. Additionally, we summarize role non-coding RNAs protein-coding genes deposition. These insights provide valuable theoretical foundation for genetic engineering high-quality high-yielding chicken breeds.

Language: Английский

Citations

1
METTL14 and WTAP play a crucial role in the regulation of bovine preadipocyte differentiation DOI Creative Commons
Jia Liu, Chicheng Ma, Liang Chen

et al.

Animal Biotechnology, Journal Year: 2025, Volume and Issue: 36(1)

Published: March 17, 2025

m6A methylation is the most common mRNA modification in mammals and plays a significant role regulating various biological functions. Some studies have demonstrated that methyltransferase METTL3 can promote adipogenesis. However, regulatory mechanisms of METTL14 WTAP, both methyltransferases, adipogenesis remain unclear. This study investigated their effects on bovine preadipocyte differentiation using siRNA-mediated knockdown combined with transcriptomic analysis. Silencing WTAP significantly impaired lipid droplet formation revealed distinct pathways: affected genes like JAK2 STAT3, while suppression down-regulated PPARγ/FABP4 signalling pathway components. These findings demonstrate specifically modulates adipocyte through pathway.

Language: Английский

Citations

0
Genomic Insights into Molecular Regulation Mechanisms of Intramuscular Fat Deposition in Chicken DOI Open Access

Yuzhu Cao,

Yuxin Xing,

Hongbo Guan

et al.

Genes, Journal Year: 2023, Volume and Issue: 14(12), P. 2197 - 2197

Published: Dec. 10, 2023

Intramuscular fat (IMF) plays an important role in the tenderness, water-holding capacity, and flavor of chicken meat, which directly affect meat quality. In recent years, regulatory mechanisms underlying IMF deposition development effective molecular markers have been hot topics poultry genetic breeding. Therefore, this review focuses on current understanding chickens, were identified by multiple genomic approaches, including genome-wide association studies, whole transcriptome sequencing, proteome single-cell RNA sequencing (scRNA-seq), high-throughput chromosome conformation capture (HiC), DNA methylation m6A sequencing. This comprehensively systematically describes epigenetic factors associated with deposition, provides a fundamental resource for biomarkers promising applications improvement quality chicken.

Language: Английский

Citations

7
Research Progress on the Role of M6A in Regulating Economic Traits in Livestock DOI Open Access
Tuanhui Ren,

Meng Xu,

X. Du

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8365 - 8365

Published: July 31, 2024

Reversible regulation of N6-methyladenosine (m6A) methylation eukaryotic RNA via methyltransferases is an important epigenetic event affecting metabolism. As such, m6A plays crucial roles in regulating animal growth, development, reproduction, and disease progression. Herein, we review the latest research advancements modifications discuss regulatory aspects context reproductive traits livestock. New insights are highlighted perspectives for study shaping economically discussed.

Language: Английский

Citations

1
4d Dia Proteomic Analysis of Gender and Age Influences on Meat Quality and Flavor in Hetian White Sheep DOI
Jing Wang, Hengxun Lin, Quanfeng Wang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
4D DIA proteomic analysis of gender and age influences on meat quality and flavor in Hetian white sheep DOI
Jing Wang, Hengxun Lin, Quanfeng Wang

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141851 - 141851

Published: Oct. 30, 2024

Language: Английский

Citations

0