Crosstalk Between the Spleen and Other Organs/Systems: Downstream Signaling Events DOI Creative Commons
Giovanni Tarantino,

Vincenzo Citro

Immuno, Journal Year: 2024, Volume and Issue: 4(4), P. 479 - 501

Published: Nov. 8, 2024

The aim of this review was to gather pieces information from available critically evaluated published articles concerning any interplay in which the spleen could be involved. For many years, has been alleged as an unnecessary biological structure, even though splenomegaly is objective finding illnesses. Indeed, previous opinion completely changed. In fact, not a passive participant or simple bystander relationship that exists between immune system and other organs. Recently, it evidenced preclinical clinical studies there are close associations parts body, leading various spleen–organ axes. Among them, gut–spleen axis, liver–spleen gut–spleen–skin brain–spleen cardio-splenic axis most explored present medical literature. Such recent sources evidence have led revolutionary new ideas being developed about spleen. What more, these observations may enable identification novel therapeutic strategies targeted at current diseases. time come make clear superfluous body part, while health operators physicians should pay more attention organ. much work remains performed assess further roles structure play.

Language: Английский

Emamectin Benzoate and Microplastics Led to Skeletal Muscle Atrophy in Common Carp via Induced Oxidative Stress, Mitochondrial Dysfunction, and Protein Synthesis and Degradation Imbalance DOI
Wenying Sun, Jing Liu, Xu Shi

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Pesticides and plastics have brought convenience to agricultural production daily life, but they also led environmental pollution through residual chemicals. Emamectin benzoate (EMB) is among the most widely used insecticides, which can cause harm health of organisms. Additionally, microplastics (MPs), a relatively new type pollutant, not only are increasing in amounts within water bodies aquatic organisms exacerbate by adsorbing other pollutants, leading mixed scenario. Nevertheless, toxicity mechanism EMB MPs on common carp skeletal muscle been elucidated. Therefore, we established exposure models for MPs, methods such as hematoxylin eosin staining, immunofluorescence JC-1 western blotting were employed investigate underlying mechanisms damage. The results vivo vitro experiments indicated that or oxidative stress, turn caused mitochondrial fusion/fission imbalance (with decreased Mfn1, Mfn2, OPA1 increased DRP1), reduced membrane potential, ATP content, protein synthesis, degradation, ultimately resulting atrophy. Joint more severe damage than single exposure, addition NAC effectively alleviate In summary, and/or induced excessive reactive oxygen species (ROS) production, giving rise dysfunction an synthesis atrophy carp.

Language: Английский

Citations

4
Birds as Bioindicators: Revealing the Widespread Impact of Microplastics DOI Creative Commons
Lara Carrasco Pesquera,

Eva Jiménez-Mora,

Maria Jose Utrilla

et al.

Birds, Journal Year: 2025, Volume and Issue: 6(1), P. 10 - 10

Published: Feb. 11, 2025

The global crisis of plastic pollution, particularly involving microplastics (MPs) and nanoplastics (NPs), has profound ecological implications. Birds, serving as bioindicators, are especially susceptible to these pollutants. This systematic review synthesizes the current research on presence, distribution, impact MPs NPs avian species, alongside advancements in detection methodologies. have been identified over 200 bird species across 46 families, encompassing several ecosystems, from Antarctica Labrador, including Australia, China, South Europe. Seabirds such penguins, gulls, shearwaters exhibit a high burden tissues feces due fishing debris, while terrestrial face contamination urban agricultural sources. Depending their composition, can cause gastrointestinal damage, oxidative stress, bioaccumulation toxic chemicals, polyethylene polypropylene. However, challenges persist methodological inconsistencies, though advances spectroscopy flow cytometry offer improved accuracy. Addressing this pollution is vital for conservation ecosystem health, requiring international collaboration standardized protocols.

Language: Английский

Citations

0
Comparative analysis of spleen structure, biochemical parameters, and transcriptome of adult and juvenile yellowfin tuna (Thunnus albacares) in the South China Sea DOI
Wei Guan, Xin Su, Ji Xu

et al.

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2025, Volume and Issue: 54, P. 101445 - 101445

Published: Feb. 16, 2025

Language: Английский

Citations

0
Microplastics: A Hidden Carrier of Per- and Polyfluoroalkyl Substances and their Effect on Soil Properties DOI
Kashif Tanzil, Anu Mary Ealias, Giphin George

et al.

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: unknown, P. 114974 - 114974

Published: Nov. 1, 2024

Language: Английский

Citations

2
Toxic effects of exposure to Polymethyl methacrylate and polyvinyl chloride microplastics in Pacific oysters (Crassostrea gigas) DOI
Chunmei Gao, Zhengwei Wu,

Baogui Liang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125484 - 125484

Published: Dec. 1, 2024

Language: Английский

Citations

1
Ferulic acid alleviates cardiac injury by inhibiting avermectin-induced oxidative stress, inflammation and apoptosis DOI
Qiao Wang, Shasha Zhang,

Jiahao Ding

et al.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 287, P. 110058 - 110058

Published: Oct. 21, 2024

Language: Английский

Citations

0
Crosstalk Between the Spleen and Other Organs/Systems: Downstream Signaling Events DOI Creative Commons
Giovanni Tarantino,

Vincenzo Citro

Immuno, Journal Year: 2024, Volume and Issue: 4(4), P. 479 - 501

Published: Nov. 8, 2024

The aim of this review was to gather pieces information from available critically evaluated published articles concerning any interplay in which the spleen could be involved. For many years, has been alleged as an unnecessary biological structure, even though splenomegaly is objective finding illnesses. Indeed, previous opinion completely changed. In fact, not a passive participant or simple bystander relationship that exists between immune system and other organs. Recently, it evidenced preclinical clinical studies there are close associations parts body, leading various spleen–organ axes. Among them, gut–spleen axis, liver–spleen gut–spleen–skin brain–spleen cardio-splenic axis most explored present medical literature. Such recent sources evidence have led revolutionary new ideas being developed about spleen. What more, these observations may enable identification novel therapeutic strategies targeted at current diseases. time come make clear superfluous body part, while health operators physicians should pay more attention organ. much work remains performed assess further roles structure play.

Language: Английский

Citations

0