Non-antibiotic growth promoters in poultry nutrition DOI Open Access
Hafiz Muhammad Ishaq,

Waqas Ishaq,

Muhammad Usman

et al.

Annals of Animal Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 24, 2024

Abstract Poultry meat and eggs are considered as major sources of food for rapidly increasing human population across the globe. During rearing poultry, different antibiotics were included in poultry diets sub therapeutic doses to attain improvements growth performance. Recently, use production has been one reasons behind emergence antibiotic resistance pathogens. The pressing issue led complete or partial bans on promoters many parts world. Moreover, there have increased concerns among consumers about residues products. These administrative an incidence bacterial disease outbreaks thus compromising performance, welfare, economic outcomes producers. This ultimately attracted attention researchers find alternative strategies that could replace bring production, health, safety benefits systems. non-antibiotic mainly include probiotics, prebiotics, synbiotics, phytogenic substances, organic acids, antimicrobial peptides, enzymes, bacteriophages, egg yolk antibodies. Inclusion these solutions demonstrates promising results terms performance birds’ health. demonstrated through nutrient absorption, proliferation beneficial bacteria, reduction pathogenic species, metabolites serve energy intestinal epithelial cells host, positive modulation immune responses. Apart from reducing colonization species also exhibited satisfactory efficacy foodborne pathogens like Salmonella Campylobacter jejuni which cause illness population. In this paper, we reviewed studies evaluated effects types poultry. A description mechanism action, advantages, disadvantages gut health parameters discussed paper.

Language: Английский

Prebiotic characteristics of degraded polysaccharides from Acanthopanax senticosus Polysaccharide on broilers gut microbiota based on in vitro digestion and fecal fermentation (Microbiology and Food Safety) DOI Creative Commons
Xueyan Wang, Jiaojiao Xue, Rui Zhang

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(7), P. 103807 - 103807

Published: April 26, 2024

This study aimed to evaluate the effect of low molecular weight Acanthopanax polysaccharides on simulated digestion, probiotics, and intestinal flora broilers in vitro. The experiments were carried out by H2O2-Vc degradation polysaccharides, vitro digestion digestive performance with different weights, probiotic evaluation lactobacilli bifidobacteria, anaerobic fermentation high-throughput sequencing 16S rRNA genes impact broilers, short-chain fatty acids intestines determined GC-MS method. results showed that polysaccharide (ASPS) was 9,543 Da, weights ASPS-1 ASPS-2 reduced 4,288 Da 3,822 after degradation, particle sizes, PDIs, viscosities also significantly decreased. has anti-digestive properties better properties. addition regulates structure microorganisms regulating fecalibacterium produce acids, promoting colonization beneficial bacteria such as fecalibacterium, paraprevotella diminishing prevalence detrimental Fusobacteria. Interestingly group found higher levels Paraprevotella, which degraded trypsin gut, reducing inflammation, acted a gut protector, influential increasing acetic acid, propionic butyric isobutyric valeric total SCFAs fermented feces. Therefore, can regulate promote production SCFAs, creating possibilities for its use potential prebiotic, is conducive health poultry.

Language: Английский

Citations

8
Effects of Qiamagu (Brassica rapa L.) polysaccharide on growth performance, immunity and gut health of yellow-feathered broilers DOI Creative Commons
Tingting Liu, Sijia Wang,

Jiaxu Yan

et al.

BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 1, 2025

This study aimed to investigate the effects of adding Qiamagu polysaccharides feed on growth performance, immunity and gut health yellow-feathered broilers. A total 240 healthy, day-old, male broiler chickens with similar body weights were randomly divided into four groups, each six replicates 10 per replicate. The groups consisted a control group (CON) three treatment groups: TP1 (250 mg/kg), TP2 (500 TP3 (1000 mg/kg) polysaccharide in diet, feeding period 64 days. average daily weight gain all experimental significantly higher than those CON (P < 0.05) 1–21 was increased 0.05), ratio decreased at 43–63 levels IgM, IgA, IgG, IL-1β, IL-2 TNF-α serum broilers exhibited consistent increase 21,42 63 day 0.05). At 22–42 days, villus length duodenum ileum Villus height crypt depth ileal mucosa IL-1β mRNA down-regulated 1–42 days MUC2, ZO-1 Occluding up-regulated 1-63days number cecal flora species TP1, that relative abundance Lactobacillus In conclusion, this showed addition improved enhanced immune response had better impact intestinal

Language: Английский

Citations

0
Targeting regulation of lipid metabolism with polysaccharide of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease: A review DOI
Wei Liu, Meng Sun, Hao Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141660 - 141660

Published: March 1, 2025

Language: Английский

Citations

0
Dietary areca nut extract supplementation modulates the growth performance and immunity of Jiaji ducks (Cairina moschata) DOI Creative Commons

Xiaohui Zhang,

Liuting Wu, Lihong Gu

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(5), P. 104971 - 104971

Published: March 5, 2025

Areca nut extract (ANE) has a variety of pharmacological effects on animals. Here, we investigated the influence ANE slaughter performance and immune function Jiaji ducks. One hundred fifty 42-day-old healthy ducks were randomly divided into 2 groups (5 replicates 15 each), named DCK group (control) DNT (treatment), respectively. Ducks in fed basal diet food supplemented with 0.08 g per kg diet. Additionally, using proteomics, untargeted metabolomics, metagenomics, analyzed impact protein profile spleen, composition plasma metabolites, structure cecal microbiota. The results showed that dietary inclusion significantly increased rate Proteomic analysis revealed 78 differentially expressed proteins spleens ANE-treated birds, including 54 up-regulated 24 down-regulated group, mainly enriched cell adhesion molecules glutathione metabolic pathways. Untargeted metabolomic 117 serum metabolites regulated between groups; meanwhile, KEGG pathway indicated these involved arachidonic acid metabolism, phospholipase D signaling eicosanoids. Furthermore, metagenomic genus Methanobrevibacter was downregulated supplementation group. Combined, analyses relative abundance Prevotella lower than negatively correlated levels anti-inflammatory compound hydrocinnamic lipid metabolism regulator ganoderic A. This study provides reference for application as supplement

Language: Английский

Citations

0
Polygonatum sibiricum Polysaccharides Alleviate LPS-Induced Liver Injury in Chicks by Suppressing Inflammation and Oxidative Stress Through the PPAR Signaling Pathway DOI Creative Commons
Yang Li, Jianping Li, Xiaowang Liu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 418 - 418

Published: March 31, 2025

Polygonatum sibiricum polysaccharides (PSPs), plant-derived widely used in the pharmaceutical field, exhibit various biological activities, including anti-inflammatory and antioxidant effects. However, research on their application chicks remains limited. Therefore, aim of this study is to investigate protective mechanism PSP against liver injury using an LPS-induced inflammatory model. A total 200 one-day-old Hy-Line Brown laying were randomly assigned five groups (40 each): a control group (CON) fed basal diet, LPS group, three receiving low (250 mg/L), medium (500 high (1000 mg/L) doses (PSP250_LPS, PSP500_LPS, PSP1000_LPS, respectively). The experiment lasted 21 days. During period, intraperitoneally injected with 1500 μg/kg days 14, 16, 18, 20, while CON received normal saline. On day 21, organs collected for analysis. results indicated that treatment significantly reduced kidney indices elevated by (p < 0.05) without affecting spleen, thymus, or bursa Fabricius > 0.05). Histological analysis revealed alleviated ballooning degeneration cell swelling hepatocytes. Furthermore, decreased levels ALT AST mitigated increases pro-inflammatory cytokines IL-1β, IL-6, TNF-α enhancing level cytokine IL-10 Transcriptome sequencing samples altered expression 10 genes peroxisome proliferator-activated receptor (PPAR) signaling pathway, which regulated intervention. qPCR validation supported these findings. biochemical analyses tissue showed oxidative stress SOD, MDA, NADPH, ROS, H2O2. In conclusion, may alleviate modulating PPAR pathway. These findings provide valuable insights promoting healthy chick rearing ensuring safe supply poultry products.

Language: Английский

Citations

0
Effect of dietary Polygonatum sibiricum polysaccharide incorporation on growth, blood metabolites, tibia mineralization, and nutrient digestibility of broilers DOI Open Access
Bing Yang, Xiaofeng Li, Noura M. Mesalam

et al.

Annals of Animal Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract This study explored the impact of incorporating Polygonatum sibiricum polysaccharide (PSP) into broilers’ diets on their growth, serum mineral levels, tibia characteristics, and nutrient digestibility. A total 240 day-old male Ross-308 broiler chicks were randomly divided three experimental groups, each consisting 8 replicates 10 birds. The birds fed supplemented with PSP at levels: 0, 400, 800 mg.kg −1 , denoted as control, 400PSP, 800PSP, respectively. Notably, 800PSP group exhibited a linear improvement in feed conversion ratio weight gain 35 days age. Crude protein calcium digestibility improved (P>0.05) by inclusion. addition did not influence carcass traits, except for relative pectoral muscle, which increased linearly group. Immune organ indexes increase PSP-fed groups. There no notable changes hepatic renal function biomarkers 21 However, age, lipid profile was affected, quadratic reductions concentrations cholesterol, LDL HDL noticed. On day calcium, potassium, iron levels increases Moreover, ash content age quadratically 400PSP In conclusion, content, minerals profile, digestibility, particularly level.

Language: Английский

Citations

0
Unlocking the power of short-chain fatty acids in ameliorating intestinal mucosal immunity: a new porcine nutritional approach DOI Creative Commons

Haoyang Liu,

Hongde Lu,

Yuxuan Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 2, 2024

Short-chain fatty acids (SCFAs), a subset of organic with carbon chains ranging from one to six atoms in length, encompass acetate, propionate, and butyrate. These compounds are the endproducts dietary fiber fermentation, primarily catalyzed by glycolysis pentose phosphate pathways within gut microbiota. SCFAs act as pivotal energy substrates signaling molecules realm animal nutrition, exerting profound influence on intestinal, immune system, intestinal barrier functions. Specifically, they contibute 60-70% total requirements ruminants 10-25% monogastric animals. have demonstrated capability effectively modulate pH, optimize absorption mineral elements, impede pathogen invasion. Moreover, enhance expression proteins associated tight junctions stimulate mucus production, thereby refining tissue morphology preserving integrity structure. Notably, also exert anti-inflammatory properties, mitigating inflammation epithelium strengthening barrier’s defensive capabilities. The present review endeavors synthesize recent findings regarding role crucial intermediaries between metabolic activities microbiota status porcine cells. It provides comprehensive overview current literature SCFAs’ impact responses mucosa.

Language: Английский

Citations

1
Effects of Purple sweet potato polysaccharide on performance, egg quality characteristics, jejunal morphology, and gut microbiota of Hy-Line Brown laying hens DOI Creative Commons
Cecilia T. Oluwabiyi, Zhigang Song

Poultry Science, Journal Year: 2024, Volume and Issue: 103(12), P. 104366 - 104366

Published: Sept. 27, 2024

Language: Английский

Citations

1
Dietary Pleurotus citrinopileatus Polysaccharide Improves Growth Performance and Meat Quality Associated with Alterations of Gut Microbiota in Arbor Acre Broilers DOI Creative Commons
Nannan Zhou, Xiaoxiao Song,

C.P. Wu

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3426 - 3426

Published: Oct. 28, 2024

Adding edible fungal polysaccharides to animal diets improves growth performance, meat quality, intestinal health, and immunity without adverse effects. This study aimed evaluate the impact of

Language: Английский

Citations

1
Effects of Isalo scorpion cytotoxic peptide on growth, immune performance, and intestinal flora of yellow-feathered broilers DOI Creative Commons
Zhengli Wang, Jianjun Zhu, Yan Ma

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 18, 2024

This study aimed to investigate the effects of Isalo scorpion cytotoxic peptide (IsCT) on growth performance, immune function, and gut microbiota yellow-feathered broilers.

Language: Английский

Citations

0