Effects of Hypericum attenuatum Choisy extract on the immunologic function and intestinal microflora of broilers under oxidative stress DOI Creative Commons
Rui Song,

Yanzhen Jiang,

Bo Zhang

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104189 - 104189

Published: Aug. 8, 2024

This study investigated the impact of Hypericum attenuatum Choisy extract (HYG) on immunological function and cecum microflora in broilers. A total 240 one-day-old AA broilers were randomly divided into 5 groups with 6 replicates 8 each: 1) CN group, which injected saline fed a basal diet; 2) PC lipolyaccharide (LPS) 3) HYG1 LPS 400 mg/kg HYG-supplemented 4) HYG2 800 5) HYG3 1,200 diet. Broilers 1 or same amount 12 hours before sampling d 21 42. The results revealed that dietary HYG supplementation alleviated spleen index thymus abnormalities, balanced disturbance serum immunoglobulin (Ig)M IgA levels, regulated cytokine balance serum, liver, jejunum tissues included induced by LPS. Dietary also downregulated relative expression inhibitor kappa B kinase alpha (IKKα) interleukin (IL)-6 mRNAs liver upregulated (IκBα) IL-10 spleen. improved cecal at 42 increasing abundance beneficial bacteria, such as Alistipes Phascolarctobacterium, while reducing harmful Helicobacter Colidextribacter. Spearman correlation analysis negative between activation NF-κB inhibitory pathway presence Erysipelatoclostridium, Subdoligranulum Parabacteroides. Conclusions: incorporation diet was optimal improving broiler function.

Language: Английский

PI3K/Akt Pathway involvement in hepatic inflammation: In silico evaluation of silybum marianum and a research proposal for homeopathic Carduus marianus DOI Open Access

Dal Pozzo Lisa

International Journal of Homoeopathic Sciences, Journal Year: 2025, Volume and Issue: 9(1), P. 167 - 183

Published: Jan. 1, 2025

Silybum marianum (SM) (L.) Gaertn is a natural remedy found in Traditional Chinese Medicine (TCM), homeopathy, and the phytotherapy compendium, often prescribed to treat liver ailments. Using silico tools based on TCM research framework, we evaluated SM bioactive compounds within context of hepatic inflammation. Through Cytoscape software STRING platform, confirmed therapeutic relevance several core targets. Via Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) enrichment analyses, characterized pathways involved The PI3K/Akt signaling pathway ranked among top three enriched pathways, with an elevated gene count high statistical significance. Based results, designed study evaluate effects homeopathic Carduus marianus (CM). By transposing "like-cures-like" diagnostic theory, propose strategy for conducting vivo ultradiluted remedies.

Language: Английский

Citations

0
Experimental Study on Myocardial Protective Effect of Xuebijing Injection on Extracorporeal Membrane Oxygenation Perfused Isolated Heart: Based on Autophagy and NLRP3 Inflammatory Pathway DOI

Shijie Yin,

Chunhua Wang, Yue Xiao

et al.

Transplantation Proceedings, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dietary supplementation with farnesol confers a protective effect on the intestine of broiler chickens challenged with lipopolysaccharide by reshaping intestinal flora structure and regulating TLR4/NF-κB signaling pathway DOI Creative Commons
Peng Li, Chenyu Guo,

Wenfei Tong

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104942 - 104942

Published: Feb. 23, 2025

Language: Английский

Citations

0
Preparation and evaluation of near-infrared and pH dual-responsive mesoporous carbon nanospheres for controlled drug release DOI

Handa Liu,

Kexin An, Ning Qiao

et al.

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130699 - 130699

Published: March 1, 2025

Language: Английский

Citations

0
The Effects of Quercetin on Vascular Endothelium, Inflammation, Cardiovascular Disease and Lipid Metabolism—A Review DOI Open Access
Mateusz Ozorowski, Michał Wiciński, Oskar Kuźmiński

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1579 - 1579

Published: May 3, 2025

Quercetin is a naturally occurring flavonoid of plant origin. This polyphenolic compound generally known for its antioxidant and anti-inflammatory properties has been reported to be factor in improving the defense system, lipid metabolism, reducing incidence cardiovascular inflammatory diseases. In this article, we will take closer look at quercetin—what it is, what has, health benefits can bring, which products found. Thanks wide spectrum action, quercetin gaining popularity as an ingredient dietary supplements, well element healthy diet supporting overall health.

Language: Английский

Citations

0
Quercetin and its nanoformulations as promising agents for lung cancer treatment: A focus on molecular mechanisms DOI
Reza Arefnezhad,

Sara Sepehri Amin,

Azam Mohammdi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105933 - 105933

Published: Sept. 1, 2024

Language: Английский

Citations

3
Effects of Hypericum attenuatum Choisy extract on the immunologic function and intestinal microflora of broilers under oxidative stress DOI Creative Commons
Rui Song,

Yanzhen Jiang,

Bo Zhang

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104189 - 104189

Published: Aug. 8, 2024

This study investigated the impact of Hypericum attenuatum Choisy extract (HYG) on immunological function and cecum microflora in broilers. A total 240 one-day-old AA broilers were randomly divided into 5 groups with 6 replicates 8 each: 1) CN group, which injected saline fed a basal diet; 2) PC lipolyaccharide (LPS) 3) HYG1 LPS 400 mg/kg HYG-supplemented 4) HYG2 800 5) HYG3 1,200 diet. Broilers 1 or same amount 12 hours before sampling d 21 42. The results revealed that dietary HYG supplementation alleviated spleen index thymus abnormalities, balanced disturbance serum immunoglobulin (Ig)M IgA levels, regulated cytokine balance serum, liver, jejunum tissues included induced by LPS. Dietary also downregulated relative expression inhibitor kappa B kinase alpha (IKKα) interleukin (IL)-6 mRNAs liver upregulated (IκBα) IL-10 spleen. improved cecal at 42 increasing abundance beneficial bacteria, such as Alistipes Phascolarctobacterium, while reducing harmful Helicobacter Colidextribacter. Spearman correlation analysis negative between activation NF-κB inhibitory pathway presence Erysipelatoclostridium, Subdoligranulum Parabacteroides. Conclusions: incorporation diet was optimal improving broiler function.

Language: Английский

Citations

1