Dietary supplementation with Bacillus subtilis KC1 alleviates the negative effects of Mycoplasma gallisepticum on growth performance and amino acid metabolism of broiler chickens DOI Creative Commons
Xueping Chen,

Jin Cui,

Yuanyuan Wang

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 23, 2024

The aim of this study was to explore whether and how Bacillus subtilis KC1 can enhance the growth performance Mycoplasma gallisepticum (MG)-infected broilers. Broilers were randomly divided into 4 groups: control group (basal diet), MG diet + challenge), KC B. supplementation), supplementation challenge). results showed that, compared group, exhibited significantly reduced body weight average daily gain, increased feed conversion ratio However, improved above indicators performance. In addition, superoxide dismutase levels malondialdehyde, interleukin-1β, tumor necrosis factor- α Furthermore, metabolomics transcriptomics analyses indicated that infection disrupted amino acid metabolism in broilers, whereas alleviated abnormal caused by MG. These suggested may alleviate poor broilers improving metabolism.

Language: Английский

Quercetin restores respiratory mucosal barrier dysfunction in Mycoplasma gallisepticum-infected chicks by enhancing Th2 immune response DOI
Shun Wang,

Liyang Guo,

Fuhua Gu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155953 - 155953

Published: Aug. 12, 2024

Language: Английский

Citations

5
Exploring preventive and treatment strategies for oral cancer: Modulation of signaling pathways and microbiota by probiotics DOI
Mohamed J. Saadh, Omer Qutaiba B. Allela,

Radhwan Abdul Kareem

et al.

Gene, Journal Year: 2025, Volume and Issue: 952, P. 149380 - 149380

Published: March 14, 2025

Language: Английский

Citations

0
Revealing the mechanism: the influence of Baicalin on M1/M2 and Th1/Th2 imbalances in mycoplasma gallisepticum infection DOI Creative Commons

Yuquan Guo,

Yusong Miao,

Hao Chen

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(10), P. 104145 - 104145

Published: July 30, 2024

Mycoplasma gallisepticum (MG) is a pathogen that induces chronic respiratory illnesses in chickens, leading to tracheal and lung injury, eliciting immune reactions support sustained colonization. Baicalin, compound found scutellaria baicalensis, exhibits anti-inflammatory, antioxidant, antibacterial properties. This study aimed investigate the potential of baicalin alleviating cell damage caused by MG restoring imbalances M1/M2 Th1/Th2 differentiation explore its underlying mechanism. In this research, model for polarization induced was initially developed. Specifically, infection with at multiplicity (MOI) 400 6 h represented M1 model, while 10 M2 model. The markers were subsequently validated using qRT-PCR, ELISA, Western blot analysis. Baicalin disrupts activation cells has restore balance between cells, thereby mitigating inflammatory resulting from MG. Subsequent studies on MG-infected chickens detected alveolar lavage fluid, as well macrophages Th lung. M1/Th1 exposed 5 d, M2/Th2 infected 7 d. utilization both light electron transmission microscopes revealed administration resulted reduction number decrease cytoplasmic vacuoles, restoration mitochondrial swelling chromatin agglutination, alleviation rupture infiltration. Furthermore, restored MG-induced inhibited phosphorylation p38 p65 proteins, hindering TLR4-p38 MAPK/NF-κB pathway. provides insights into long-term effects offers theoretical basis practical applications.

Language: Английский

Citations

3
Dietary supplementation with Bacillus subtilis KC1 alleviates the negative effects of Mycoplasma gallisepticum on growth performance and amino acid metabolism of broiler chickens DOI Creative Commons
Xueping Chen,

Jin Cui,

Yuanyuan Wang

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 23, 2024

The aim of this study was to explore whether and how Bacillus subtilis KC1 can enhance the growth performance Mycoplasma gallisepticum (MG)-infected broilers. Broilers were randomly divided into 4 groups: control group (basal diet), MG diet + challenge), KC B. supplementation), supplementation challenge). results showed that, compared group, exhibited significantly reduced body weight average daily gain, increased feed conversion ratio However, improved above indicators performance. In addition, superoxide dismutase levels malondialdehyde, interleukin-1β, tumor necrosis factor- α Furthermore, metabolomics transcriptomics analyses indicated that infection disrupted amino acid metabolism in broilers, whereas alleviated abnormal caused by MG. These suggested may alleviate poor broilers improving metabolism.

Language: Английский

Citations

0