Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli DOI Creative Commons

Ningning Mao,

Yaming Yu,

J. Cui

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104520 - 104520

Published: Nov. 9, 2024

Avian pathogenic Escherichia coli (APEC) is a major cause of avian colibacillosis. Matrine, natural component derived from Sophora flavescens, exhibits various pharmacological effects, including anti-inflammatory and antioxidant activities. However, its role in mitigating APEC-induced intestinal damage chickens remains insufficiently understood. This study aimed to explore the protective effects potential mechanisms matrine against damage. Chickens were administered (10 or 20 mg/kg) 6 days old for 5 days, followed by an APEC intraperitoneal injection on day 10. After 72 h infection, tissues collected analysis. Results indicated that pretreatment with alleviated symptoms infection chickens, improving survival rates promoting weight gain. Additionally, reduced secretion gene expression IL-1β, IL-6, TNF-α tissues, while enhancing serum SOD, GSH, CAT activity, as well levels intestine. Pretreatment TLR4, MyD88, NF-κB tissues. Moreover, ameliorated inflammation pathological damage, restoring ZO-1, Occludin, MUC2 intestine during infection. Furthermore, gut microbiota dysbiosis lowering abundance harmful bacteria. In summary, potentially inhibiting signaling pathway reshaping microbiota. These findings provide promising insights into prevention treatment

Language: Английский

Quantitative Analysis of Peanut Skin Adulterants by Fourier Transform Near-Infrared Spectroscopy Combined with Chemometrics DOI Creative Commons

Wangfei Luo,

Jihong Deng, Chenxi Li

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 466 - 466

Published: Feb. 1, 2025

Peanut skin is a potential medicinal material. The adulteration of peanut samples with starchy substances severely affects their value. This study aimed to quantitatively analyze the adulterants present in using Fourier transform near-infrared (FT-NIR) spectroscopy. Two adulterants, sweet potato starch and corn starch, were included this study. First, spectral information adulterated was collected for characterization. Then, applicability different preprocessing methods techniques obtained data compared. Subsequently, Competitive Adaptive Reweighted Sampling (CARS) algorithm used extract effective variables from preprocessed data, Partial Least Squares Regression (PLSR), Support Vector Machine (SVM), Black Kite Algorithm-Support (BKA-SVM) employed predict adulterant content samples, as well overall level. results showed that BKA-SVM model performed excellently predicting determination coefficients (RP2) 0.9833, 0.9893, 0.9987, respectively. experimental indicate FT-NIR spectroscopy combined advanced machine learning can effectively accurately detect skin, providing reliable technological support food safety detection.

Language: Английский

Citations

0
Effects of Astaxanthin on Growth Performance, Intestinal Integrity, and Microbiota in Salmonella Enteritidis-Infected Chickens DOI Creative Commons
Yong Lin, Jiansen Gong, Colin Buttimer

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: unknown, P. 105056 - 105056

Published: March 1, 2025

This study investigated the effects of astaxanthin (AST) supplementation in drinking water on growth performance, intestinal barrier function, and cecal microbiota broilers challenged with Salmonella Enteritidis. During 20-day experiment, two hundred forty 1-day-old male Arbor Acres birds were randomly assigned into a 2 × factorial design four groups: non-challenged control (CON), an S. Enteritidis-challenged group (SA), receiving AST treatment (AST), (SA+AST). Each comprised six replicate groups, groups inoculated Enteritidis from day to 4. The results indicated that infection significantly reduced average daily feed intake (ADFI) adversely affected gain (ADG) conversion ratio (FCR) by 20. improved FCR. While did not affect ileal mucosa antioxidation, it decreased villus height height-to-crypt depth (VCR), downregulated mRNA expression ZO-1 Occludin. However, enhanced antioxidant capacity (T-AOC), increased VCR ileum, notably upregulated MUC2 levels, particularly mitigating adverse crypt depth. Furthermore, both α- β-diversity microbiota. Infection was associated changes at phylum level, including significant increases Alistipes, unclassified_f__Lachnospiraceae, bacteria Clostridia UCG-014 grouping, alongside notable decreases Bacteroides, Akkermansia, Blautia, Butyricicoccus. abundance norank_f__Ruminococcaceae Lachnoclostridium unclassified_f__Lachnospiraceae group. In conclusion, could improve performance health

Language: Английский

Citations

0
Peanuts (Arachis hypogea L.) in Food Industry and their Benefits for Human Health – a Review of the Current Literature DOI

Nathalia. M. Mendes,

Yandra Cervelim Nunes,

Enzo Pereira de Lima

et al.

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107574 - 107574

Published: April 1, 2025

Language: Английский

Citations

0
Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli DOI Creative Commons

Ningning Mao,

Yaming Yu,

J. Cui

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 104(1), P. 104520 - 104520

Published: Nov. 9, 2024

Avian pathogenic Escherichia coli (APEC) is a major cause of avian colibacillosis. Matrine, natural component derived from Sophora flavescens, exhibits various pharmacological effects, including anti-inflammatory and antioxidant activities. However, its role in mitigating APEC-induced intestinal damage chickens remains insufficiently understood. This study aimed to explore the protective effects potential mechanisms matrine against damage. Chickens were administered (10 or 20 mg/kg) 6 days old for 5 days, followed by an APEC intraperitoneal injection on day 10. After 72 h infection, tissues collected analysis. Results indicated that pretreatment with alleviated symptoms infection chickens, improving survival rates promoting weight gain. Additionally, reduced secretion gene expression IL-1β, IL-6, TNF-α tissues, while enhancing serum SOD, GSH, CAT activity, as well levels intestine. Pretreatment TLR4, MyD88, NF-κB tissues. Moreover, ameliorated inflammation pathological damage, restoring ZO-1, Occludin, MUC2 intestine during infection. Furthermore, gut microbiota dysbiosis lowering abundance harmful bacteria. In summary, potentially inhibiting signaling pathway reshaping microbiota. These findings provide promising insights into prevention treatment

Language: Английский

Citations

2