Molecular Docking of Key Compounds from Acacia Honey and Nigella sativa Oil and Experimental Validation for Colitis Treatment in Albino Mice DOI Creative Commons

M Bibi,

Irfan Baboo,

Hamid Majeed

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1035 - 1035

Published: Dec. 11, 2024

Colitis, an inflammatory condition of the colon that encompasses ulcerative colitis (UC) and Crohn's disease, presents significant challenges due to limitations side effects current treatments. This study investigates potential natural products, specifically AH NSO, as organic therapeutic agents for colitis. Molecular docking studies were conducted identify binding affinities interaction mechanisms between bioactive compounds in NSO proteins implicated colitis, such those involved inflammation oxidative stress pathways. An vivo experiment was performed using albino mouse model with clinical symptoms, histopathological assessments, biochemical analyses evaluate both individually combination. Results from molecular revealed promising interactions fructose Prostaglandin G/H synthase 2 (Ptgs2) cellular tumor antigen p53, energy measured at -6.0 kcal/mol -5.1 kcal/mol, respectively. Meanwhile, presence glucose molecule glucokinase chain A (-6.3 kcal/mol) B (-5.8 indicated efficacy modulating Experimental data demonstrated treatment significantly reduced inflammation, improved gut health, ameliorated symptoms. Histopathological evaluations confirmed mucosal damage immune cell infiltration, while showed normalization markers levels. provides compelling evidence natural, complementary treatments suggesting their future role integrative strategies. However, further research into long-term safety, optimal dosing, action is warranted translate these findings applications.

Language: Английский

Probiotic post feed restriction supplementation on realimentation performances, carcass characteristic, gut morphology and gut microbes of broiler chicken DOI Creative Commons

Razieh Valipourian,

F. Shariatmadari, Hamed Ahmadi

et al.

The Journal of Applied Poultry Research, Journal Year: 2024, Volume and Issue: unknown, P. 100502 - 100502

Published: Nov. 1, 2024

Language: Английский

Citations

0
Molecular Docking of Key Compounds from Acacia Honey and Nigella sativa Oil and Experimental Validation for Colitis Treatment in Albino Mice DOI Creative Commons

M Bibi,

Irfan Baboo,

Hamid Majeed

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1035 - 1035

Published: Dec. 11, 2024

Colitis, an inflammatory condition of the colon that encompasses ulcerative colitis (UC) and Crohn's disease, presents significant challenges due to limitations side effects current treatments. This study investigates potential natural products, specifically AH NSO, as organic therapeutic agents for colitis. Molecular docking studies were conducted identify binding affinities interaction mechanisms between bioactive compounds in NSO proteins implicated colitis, such those involved inflammation oxidative stress pathways. An vivo experiment was performed using albino mouse model with clinical symptoms, histopathological assessments, biochemical analyses evaluate both individually combination. Results from molecular revealed promising interactions fructose Prostaglandin G/H synthase 2 (Ptgs2) cellular tumor antigen p53, energy measured at -6.0 kcal/mol -5.1 kcal/mol, respectively. Meanwhile, presence glucose molecule glucokinase chain A (-6.3 kcal/mol) B (-5.8 indicated efficacy modulating Experimental data demonstrated treatment significantly reduced inflammation, improved gut health, ameliorated symptoms. Histopathological evaluations confirmed mucosal damage immune cell infiltration, while showed normalization markers levels. provides compelling evidence natural, complementary treatments suggesting their future role integrative strategies. However, further research into long-term safety, optimal dosing, action is warranted translate these findings applications.

Language: Английский

Citations

0