Selenium Broussonetia papyrifera polysaccharide alleviated cyclophosphamide-induced immune suppression, growth inhibition, intestinal damage, and gut microbiota disorder in yellow-feather broilers.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104907 - 104907

Published: Feb. 17, 2025

This study aims to investigate the effects of selenium Broussonetia papyrifera polysaccharide (Se-BPP) on growth performance, immune regulation, intestinal barrier function, and gut microbiota in cyclophosphamide (CTX)-induced immunosuppressed chicks. A total 120 one-day-old male yellow-feathered broilers were randomly divided into five groups: normal control group (NC), model (MC), low-dose Se-BPP (Se-L), high-dose (Se-H), Astragalus (APS) The Se-L Se-H groups supplemented with 0.1 % or 0.2 Se-BPP, respectively, while APS was APS. On days 22, 24, 26, NC received intramuscular injections 80 mg/kg saline, other same dose CTX induce immunosuppression results showed that caused retardation, immunosuppression, damage, alterations structure. Supplementation improved average daily gain reduced feed-to-gain ratio, promoting increased organ index serum content IgG, IgM, IgA, SOD, GSH-Px, CAT, IL-2, IL-4, IL-6, IL-10, INF-γ, thus alleviating oxidative stress by CTX. Additionally, enhanced mRNA expression levels ZO-1, Claudin 1, MUC2 villus height jejunum, effectively mitigating damage induced Although effect alpha diversity not significant, it abundance beneficial bacteria such as Ruminococcus Lactobacillus. In brief, this demonstrated adding diet could improve disturbances yellow-feather broiler chickens challenged CTX, enhancing their production performance.

Language: Английский

Comparative Effects of Organic and Nano-Selenium on Egg Quality and Antioxidant Capacity in Layer Hens

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1454 - 1454

Published: April 23, 2025

This study evaluates the effects of dietary selenium (Se) sources—sodium selenite (SS), nano-selenium (Nano-Se), selenocysteine (Se-C), and selenomethionine (Se-Met)—on production performance, egg quality, preservation characteristics, yolk Se content, antioxidant capacity in Hy-Line Grey laying hens. A total 450 healthy 18-week-old hens were allocated to five groups (basal diet without Se, 0.30 mg/kg SS, Nano-Se, Se-C, or Se-Met) for an 8-week trial after a 4-week Se-depletion phase. The key results demonstrate that while no significant differences observed feed intake, rate, weight among (p > 0.05), organic (Se-C, Nano-Se significantly improved color < 0.05) index mitigated declines albumen height Haugh unit during storage. Notably, exhibited superior efficacy enhancing enzyme activity 0.05). Furthermore, increased deposition reduced lipid peroxidation These findings indicate supplementing 0.3 enhances extends shelf life, improves capacity, offering sustainable strategy selenium-enriched production.

Language: Английский

D-Glucuronolactone Supplementation Enhances Production Performance, Eggshell Quality, and Liver Health in Laying Hens

Animals, Journal Year: 2025, Volume and Issue: 15(9), P. 1317 - 1317

Published: May 1, 2025

The liver of hens bears a very heavy workload in handling lipogenesis as well carbohydrate, protein, and other nutrient metabolism to maintain high laying rate. D-glucuronolactone (DGL) is naturally occurring chemical metabolite produced from glucose exhibits hepatoprotective effect food ingredient. This study aimed evaluate the DGL on production performance, egg quality, health during their peak period. Four hundred eighty Hy-Line brown (aged 42 weeks), with comparable high-laying were randomly assigned four groups, each group consisting eight replicates. control was fed basal diet, while treatment groups supplemented at 70, 140, 280 mg/kg respectively. results indicated that supplementation significantly increases rate mass (p < 0.05). color eggshell deepened by administration Additionally, decreased serum levels aspartate aminotransferase γ-glutamyl transpeptidase index, fat, triglyceride had also Liver histopathological showed exhibited yellow coloration large gaps numerous vacuolar cells, improved compactness parenchyma. Antioxidant activity enhanced, showing significant increase total antioxidant capacity catalase inflammatory response alleviated, decrease expressions interleukin-β, tumor necrosis factor-α, interferon-α, interleukin-6, interleukin-8 genes Moreover, reduced cell apoptosis-related genes, including factor-related apoptosis, Caspase 7, BCL2 associated X protein Overall, these findings indicate dietary enhanced performance maintaining health, best achieved dose this trial.

Language: Английский