Blockade of Voltage‐Gated K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells by the Antipsychotic Drug Zotepine DOI Open Access

Wenwen Zhuang,

Minju Park,

Junsu Jeong

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

ABSTRACT Zotepine is a second‐generation antipsychotic that demonstrates significant efficacy in antagonizing D 2 and 5‐HT 2A receptors. Although clinical investigations have shown administering zotepine associated with an increased prevalence of hyperglycemia heightened risk cardiovascular disease, the side effects on voltage‐gated K + (Kv) channels not been established. suppressed vascular Kv rabbit coronary arterial smooth muscle cells concentration‐dependent manner, IC 50 5.3 ± 0.4 μM Hill coefficient 1.6 0.2. The decay rate inactivation was significantly accelerated by zotepine. Applying (10 μM) shifted steady‐state curve negative direction. train pulses at 1 Hz resulted progressive increase blockage currents Furthermore, prolonged recovery time from inactivation. pretreatment Kv2.1 subtype inhibitor stromatoxin‐1 Kv7 linopirdine did change degree zotepine‐induced inhibition currents, Kv1.5 channel DPO‐1 decreased inhibitory currents. also induced membrane depolarization. These results indicate inhibits (mainly subtype) dose‐, time‐, use (state)‐dependent manners changing curve.

Language: Английский

Unlocking the Link Between Gut Microbiota and Psychopathological Insights in Anorexia Nervosa: A Systematic Review DOI Open Access

Mauro Scala,

Mariangela Tabone, Marco Paolini

et al.

European Eating Disorders Review, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

This systematic review explores the associations between qualitative/quantitative changes in gut microbiota and psychopathological symptoms or other clinical features patients with eating disorders (EDs). Secondary outcomes include exploring EDs potential relationships psychotropic drug use. A search was conducted across biomedical databases from inception to June 2024 according PRISMA guidelines. The risk of bias assessed, a narrative synthesis performed due heterogeneity outcomes. Only findings related anorexia nervosa (AN) were identified. Ten studies, which seven longitudinal, two cross-sectional, one interventional (N = 350 AN, 304 HCs), included. Despite no clear links diversity metrics being observed, specific taxa belonging phylum Firmicutes, such as Clostridium, Roseburia, Lactobacillus, Faecalibacterium, Bifidobacterium Actinobacteriota correlated ED psychopathology, including anxiety depressive symptoms. Changes symptoms, well altered behaviours by modulating inflammation insulin pathways through short-chain fatty acids (SCFAs), that also lead neurotransmitter imbalances. Further studies are required replicate these finding explore whether similar patterns observed EDs.

Language: Английский

Citations

0
Evaluating the Efficacy of Secondary Metabolites in Antibiotic-Induced Dysbiosis: A Narrative Review of Preclinical Studies DOI Creative Commons
Corina Andrei, Anca Zanfirescu,

Victor-Pierre Ormeneanu

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 138 - 138

Published: Feb. 1, 2025

Background/Objectives: Drug-induced dysbiosis, particularly from antibiotics, has emerged as a significant contributor to chronic diseases by disrupting gut microbiota composition and function. Plant-derived secondary metabolites, such polysaccharides, polyphenols, alkaloids, saponins, show potential in mitigating antibiotic-induced dysbiosis. This review aims consolidate evidence preclinical studies on the therapeutic effects of metabolites restoring microbial balance, emphasizing their mechanisms efficacy. Methods: A narrative was conducted using PubMed, Scopus, Web Science. Studies were selected based specific inclusion criteria, focusing animal models treated with for The search terms included “gut microbiota”, “antibiotics”, “secondary metabolites”. Data extraction focused alterations, metabolite-specific effects, action. Relevant findings systematically analyzed summarized. Results: Secondary demonstrated diverse impact dysbiosis modulating composition, reducing inflammation, supporting host biological markers. Polysaccharides polyphenols restored Firmicutes/Bacteroidetes ratio, increased beneficial taxa Lactobacillus Bifidobacterium, suppressed pathogenic bacteria like Escherichia-Shigella. Metabolites triterpenoid saponins enhanced barrier integrity upregulating tight junction proteins, while alkaloids reduced inflammation proinflammatory cytokines (e.g., TNF-α, IL-1β). These also improved short-chain fatty acid production, which is crucial systemic health. While primary focus, other drug classes PPIs, metformin) require further investigation. Conclusions: promise managing improving Future research should explore applicability types drug-induced validate human enhance clinical relevance.

Language: Английский

Citations

0
Oropharyngeal microbiota in patients with psychotic disorders: A scoping review on compositional and functional alterations DOI Creative Commons

Mauro Scala,

María del Rocío González Soltero,

Á. Esteban

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111288 - 111288

Published: Feb. 7, 2025

Language: Английский

Citations

0
Microbiome-Gut-Brain Profiles in Schizophrenia and Their Potential Link to Cognitive Performance: Findings from a Case–Control Study DOI
Hui Wu,

Xu Jiawei,

Zhi Wen

et al.

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Increasing evidence indicates the role of microbiome-gut-brain axis in schizophrenia (SZ). However, few studies have examined potential links among gut microbiome, brain structure and function, clinical manifestation SZ patients, effects prolonged antipsychotic treatment are often neglected. A total 171 participants were enrolled, including 27 drug-naïve first-episode patients (FSZ), 72 chronically antipsychotics-treated (CSZ), healthy controls (HCs). Multi-omics data, fecal 16S rRNA sequencing, structural functional imaging analyses, assessments psychotic symptoms cognitive obtained to characterize patients. Correlation mediation analyses conducted assess relationships neuroimaging features, manifestations. Compared with HCs, 3 key diagnostic genera identified SZ, characterized by decreased abundance Blautia (FSZ/CSZ < HCs) increased Proteus Arthrobacter (FSZ > CSZ HCs). This microbial dysbiosis was accompanied down-regulated bile acids biosynthesis up-regulated lipid metabolism. Further revealed a tripartite relationship genera, altered separate subgroups. Importantly, higher may result lower scores on several domains disrupting gray matter volume regional homogeneity specific regions. work advances our knowledge microbiota-gut-brain disturbances its performance SZ. Moreover, results highlight importance considering exposure gut-brain research.

Language: Английский

Citations

0
Gut microbiome characteristics in individuals across different stages of schizophrenia spectrum disorders: A systematic review and meta-analysis DOI
Li Kong, Xingsong Wang, Guanlin Chen

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106167 - 106167

Published: April 1, 2025

Language: Английский

Citations

0
Gut Microbiota in Immuno-Oncology: A Practical Guide for Medical Oncologists With a Focus on Antibiotics Stewardship DOI
Arielle Elkrief, Bertrand Routy, Lisa Derosa

et al.

American Society of Clinical Oncology Educational Book, Journal Year: 2025, Volume and Issue: 45(3)

Published: April 22, 2025

The gut microbiota has emerged as a critical determinant of immune checkpoint inhibitor (ICI) efficacy, resistance, and toxicity. Retrospective prospective studies profiling the taxonomic composition intestinal microbes patients treated with ICI have revealed specific microbial signatures associated response. By contrast, dysbiosis, which can be caused by chronic inflammatory processes (such cancer) or comedications, is risk factor resistance to ICI. Recent large-scale meta-analyses confirmed that antibiotic (ATB) use before during therapy alters repertoire significantly shortens overall survival, even after adjusting for prognostic factors. These results underscore importance implementing ATB stewardship recommendations in routine oncology practice. Microbiota-centered interventions are now being explored treat dysbiosis optimize responses. Early-phase clinical trials evaluating fecal transplantation (FMT) from responders healthy donors shown this approach safe provided preliminary data on potential efficacy overcome both primary secondary melanoma, non–small cell lung cancer, renal carcinoma. More targeted including live bacterial products Clostridium butyricum Akkermansia massiliensis represent novel microbiome-based adjunct therapies. Likewise, dietary interventions, such high-fiber diets, promise enhancing activity. In ASCO Educational Book, we summarize current state-of-the-evidence relevance cancer immunotherapy provide practical guide stewardship.

Language: Английский

Citations

0
Schizophrenia and antipsychotic medications present distinct and shared gut microbial composition: A meta-analysis DOI

Cheng Wei-rong,

Mengjie Zhao, Xinyun Zhang

et al.

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 274, P. 257 - 268

Published: Oct. 9, 2024

Language: Английский

Citations

1
Blockade of Voltage‐Gated K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells by the Antipsychotic Drug Zotepine DOI Open Access

Wenwen Zhuang,

Minju Park,

Junsu Jeong

et al.

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

ABSTRACT Zotepine is a second‐generation antipsychotic that demonstrates significant efficacy in antagonizing D 2 and 5‐HT 2A receptors. Although clinical investigations have shown administering zotepine associated with an increased prevalence of hyperglycemia heightened risk cardiovascular disease, the side effects on voltage‐gated K + (Kv) channels not been established. suppressed vascular Kv rabbit coronary arterial smooth muscle cells concentration‐dependent manner, IC 50 5.3 ± 0.4 μM Hill coefficient 1.6 0.2. The decay rate inactivation was significantly accelerated by zotepine. Applying (10 μM) shifted steady‐state curve negative direction. train pulses at 1 Hz resulted progressive increase blockage currents Furthermore, prolonged recovery time from inactivation. pretreatment Kv2.1 subtype inhibitor stromatoxin‐1 Kv7 linopirdine did change degree zotepine‐induced inhibition currents, Kv1.5 channel DPO‐1 decreased inhibitory currents. also induced membrane depolarization. These results indicate inhibits (mainly subtype) dose‐, time‐, use (state)‐dependent manners changing curve.

Language: Английский

Citations

0