Rising mortality among people who inject drugs living with HIV in Scotland, UK: A 20‐year retrospective cohort study DOI Creative Commons

Rebecca Metcalfe,

Robert D. Fraser, Kirsten M. A. Trayner

et al.

HIV Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Objectives Our aim was to examine mortality trends in the era of antiretroviral therapy, among people who inject drugs (PWID) are living with HIV. The study objectives were assess and quantify PWID diagnosed HIV over time Scotland, context a recent outbreak rise drug‐related mortality. Methods This retrospective cohort those Scotland between January 2000 February 2020, acquisition related injecting drug use, linked data. Factors associated all‐cause examined using Cox proportional hazards regression. Results Among 430 individuals 3143 person‐years (py) follow‐up, 88 (20.5%) died. Drug‐related deaths accounted for 45.5% all deaths, rising 60% 2015–2020. crude 28.00 per 1000 py overall 37.62 within 5 years diagnosis. Mortality risk markedly higher 2015–2020 [adjusted hazard ratio (aHR) = 3.53], relative 2000–2004. (as part outbreak), not on, compared opioid agonist therapy (aHR 3.87). Conclusion has risen substantially 21st century. findings highlight important role opioid‐agonist alongside other prevention treatment measures address high levels HIV, including outbreaks this population group.

Language: Английский

Individuals 45 Years and Older in Opioid Agonist Treatment: A Scoping Review DOI Open Access
Zhanna Gaulen, Linn-Heidi Lunde, Silvia Eiken Alpers

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(3), P. 458 - 458

Published: March 20, 2025

This scoping review explores the unique challenges and needs faced by ageing individuals, aged 45 above, in opioid agonist treatment (OAT), noting earlier onset of age-related impairments among this population. The literature search was conducted PsycINFO, EMBASE, MEDLINE, CINAHL, Web Science. A total 28 observational studies were included. Five topics identified: health, treatment, substance use, demographic, social aspects. Findings reveal that, while health concerns are often discussed literature, limited attention has been given to gender differences, factors such as financial issues, psychological factors, which also critical aspects lives individuals undergoing OAT. emphasizes importance expanding research address these gaps, ultimately aiming improve their overall well-being.

Language: Английский

Citations

0
Rising mortality among people who inject drugs living with HIV in Scotland, UK: A 20‐year retrospective cohort study DOI Creative Commons

Rebecca Metcalfe,

Robert D. Fraser, Kirsten M. A. Trayner

et al.

HIV Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Objectives Our aim was to examine mortality trends in the era of antiretroviral therapy, among people who inject drugs (PWID) are living with HIV. The study objectives were assess and quantify PWID diagnosed HIV over time Scotland, context a recent outbreak rise drug‐related mortality. Methods This retrospective cohort those Scotland between January 2000 February 2020, acquisition related injecting drug use, linked data. Factors associated all‐cause examined using Cox proportional hazards regression. Results Among 430 individuals 3143 person‐years (py) follow‐up, 88 (20.5%) died. Drug‐related deaths accounted for 45.5% all deaths, rising 60% 2015–2020. crude 28.00 per 1000 py overall 37.62 within 5 years diagnosis. Mortality risk markedly higher 2015–2020 [adjusted hazard ratio (aHR) = 3.53], relative 2000–2004. (as part outbreak), not on, compared opioid agonist therapy (aHR 3.87). Conclusion has risen substantially 21st century. findings highlight important role opioid‐agonist alongside other prevention treatment measures address high levels HIV, including outbreaks this population group.

Language: Английский

Citations

1