Stem cell therapy for the treatment of psychiatric disorders: a real hope for the next decades

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

In this review, it is evaluated the progress in application of stem cell therapy to ameliorate symptoms bipolar disorder, major depression, schizophrenia, and autism. These disorders are highly prevalent clinical medicine responsible for high levels psychosocial disability among patients. All them share common biomedical features, such as complex variable genetic substrates, significant susceptibility environmental changes, insufficient knowledge their pathogenesis. addition, responsiveness patients pharmacological treatment heterogeneous, some cases, no available. Therefore, development cell-based regenerative its possible combination with emerging therapeutic approaches that promote neural plasticity expected advance neuropsychiatry next few decades.

Language: Английский

The use of induced pluripotent stem cells as a platform for the study of depression

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 9, 2024

The neurobiological mechanisms underlying major depressive disorder (MDD) remain largely unexplored due to the limited availability of study models in humans. Induced pluripotent stem cells (iPSCs) have overcome multiple limitations retrospective clinical studies, contributing a more detailed understanding molecular pathways that presumably contribute manifestation depression. Despite significant progress made by these models, there are still formidable challenges will eventually be addressed platforms, as further studies may emerge. This review examine most recent advances comprehension depression using human neurons and non-neuronal derived from induced patients with highlights importance platforms increase our knowledge address this psychiatric efficiently.

Language: Английский