Stress and Health: A Review of Psychobiological Processes

Annual Review of Psychology, Journal Year: 2020, Volume and Issue: 72(1), P. 663 - 688

Published: Sept. 4, 2020

The cumulative science linking stress to negative health outcomes is vast. Stress can affect directly, through autonomic and neuroendocrine responses, but also indirectly, changes in behaviors. In this review, we present a brief overview of (a) why should be interested the context health; (b) response allostatic load; (c) some key biological mechanisms which impacts health, such as by influencing hypothalamic-pituitary-adrenal axis regulation cortisol dynamics, nervous system, gene expression; (d) evidence clinical relevance stress, exemplified risk infectious diseases. studies reviewed article confirm that has an impact on multiple systems. Future work ought consider further importance early-life adversity continue explore how different systems interact processes.

Language: Английский

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Happiness and Health

Annual Review of Public Health, Journal Year: 2019, Volume and Issue: 40(1), P. 339 - 359

Published: Jan. 2, 2019

Research into the relationship between happiness and health is developing rapidly, exploring possibility that impaired not only a consequence of ill-health but also potential contributor to disease risk. Happiness encompasses several constructs, including affective well-being (feelings joy pleasure), eudaimonic (sense meaning purpose in life), evaluative (life satisfaction). generally associated with reduced mortality prospective observational studies, albeit discrepant results. Confounding reverse causation are major concerns. Associations morbidity prognosis have been identified for limited range conditions. The mechanisms potentially linking include lifestyle factors, such as physical activity dietary choice, biological processes, involving neuroendocrine, inflammatory, metabolic pathways. Interventions yet demonstrate substantial, sustained improvements subjective or direct impact on outcomes. Nevertheless, this field shows great potential, promise establishing favorable effect population health.

Language: Английский

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Students’ mental health problems before, during, and after COVID-19 lockdown in Italy

Journal of Psychiatric Research, Journal Year: 2020, Volume and Issue: 134, P. 69 - 77

Published: Dec. 21, 2020

Language: Английский

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Rethinking minority stress: A social safety perspective on the health effects of stigma in sexually-diverse and gender-diverse populations

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 138, P. 104720 - 104720

Published: June 2, 2022

Language: Английский

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Do workplace-based mindfulness meditation programs improve physiological indices of stress? A systematic review and meta-analysis

Journal of Psychosomatic Research, Journal Year: 2018, Volume and Issue: 114, P. 62 - 71

Published: Sept. 22, 2018

Language: Английский

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Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic Stress

Current Cardiology Reports, Journal Year: 2019, Volume and Issue: 21(10)

Published: Aug. 30, 2019

Abstract Purpose of Review This review focuses on the concentration cortisol in human hair as a biomarker chronic stress cardiovascular disease (CVD). We outline consequences excess and provide comprehensive overview recent studies investigating relationship with CVD. In addition, clinical implications limitations evidence are discussed, together directions for future research. Recent Findings Hair may be reliable since it provides quantification total secreted into over several weeks. A growing body suggests that elevated levels associated both incidence CVD poorer recovery treatment outcomes. Moreover, increased has been linked established cardiometabolic risk factors including high blood pressure, diabetes, adiposity. Summary is promising which contribute to pathogenesis prognosis However, current relies small-scale cross-sectional studies. Further research adopting longitudinal designs across larger samples patients healthy participants required inform development novel evidence-based interventions.

Language: Английский

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Cortisol AuPd plasmonic unclad POF biosensor

Biotechnology Reports, Journal Year: 2021, Volume and Issue: 29, P. e00587 - e00587

Published: Jan. 10, 2021

This paper presents the development and feasibility tests of a cortisol immunosensor. The sensor is based on surface plasmon resonance (SPR) using an unclad plastic optical fiber (POF) in which SPR used as sensitivity enhancer, promoted by gold/palladium (AuPd) alloy coating. AuPd coated fibers were functionalized with anti-cortisol antibody passivated bovine serum albumin (BSA) to be tested presence target analyte. antibody-antigen binding reaction caused variation refractive index coating, leads shift signature wavelength. was for different concentrations, ranging from 0.005 10 ng/mL. reported biosensor presented total wavelength 15 nm testing range, putting evidence high sensitivity. Control selectivity assessment also performed. Concentrations ng/mL cortisol, anti-hCG antibodies, only resulted 1 wavelength, times lower than one indicates proposed approach. For this sensing approach limit detection (LOD) determined pg/mL. POF has low-cost interrogation method, low LOD, straightforward signal processing find important applications biological fields.

Language: Английский

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A synergistic mindsets intervention protects adolescents from stress

Nature, Journal Year: 2022, Volume and Issue: 607(7919), P. 512 - 520

Published: July 6, 2022

Abstract Social-evaluative stressors—experiences in which people feel they could be judged negatively—pose a major threat to adolescent mental health 1–3 and can cause young disengage from stressful pursuits, resulting missed opportunities acquire valuable skills. Here we show that replicable benefits for the stress responses of adolescents achieved with short (around 30-min), scalable 'synergistic mindsets' intervention. This intervention, is self-administered online training module, synergistically targets both growth mindsets 4 (the idea intelligence developed) stress-can-be-enhancing 5 one’s physiological response fuel optimal performance). In six double-blind, randomized, controlled experiments were conducted secondary post-secondary students United States, synergistic intervention improved stress-related cognitions (study 1, n = 2,717; study 2, 755), cardiovascular reactivity 3, 160; 4, 200), daily cortisol levels 5, 118 students, 1,213 observations), psychological well-being (studies 5), academic success 5) anxiety symptoms during 2020 COVID-19 lockdowns 6, 341). Heterogeneity analyses 6) four-cell experiment 4) showed depended on addressing mindsets—growth stress—synergistically. Confidence these conclusions comes conservative, Bayesian machine-learning statistical method detecting heterogeneous effects 6 . Thus, our research has identified treatment could, principle, scaled nationally at low cost.

Language: Английский

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Enhancing precision in human neuroscience

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Aug. 9, 2023

Human neuroscience has always been pushing the boundary of what is measurable. During last decade, concerns about statistical power and replicability – in science general, but also specifically human have fueled an extensive debate. One important insight from this discourse need for larger samples, which naturally increases power. An alternative to increase precision measurements, focus review. This option often overlooked, even though benefits increasing as much sample size. Nonetheless, at heart good scientific practice neuroscience, with researchers relying on lab traditions or rules thumb ensure sufficient their studies. In review, we encourage a more systematic approach precision. We start by introducing measurement its importance well-powered studies neuroscience. Then, determinants range neuroscientific methods (MRI, M/EEG, EDA, Eye-Tracking, Endocrinology) are elaborated. end discussing how evaluation application respective insights can lead reproducibility

Language: Английский

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Salivary Biomarkers for Alzheimer’s Disease: A Systematic Review with Meta-Analysis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1168 - 1168

Published: Jan. 18, 2024

Alzheimer’s Disease (AD) is the most common neurodegenerative disease which manifests with progressive cognitive impairment, leading to dementia. Considering noninvasive collection of saliva, we designed systematic review answer question “Are salivary biomarkers reliable for diagnosis Disease?” Following inclusion and exclusion criteria, 30 studies were included in this (according PRISMA statement guidelines). Potential include mainly proteins, metabolites even miRNAs. Based on meta-analysis, AD patients, levels beta-amyloid42 p-tau significantly increased, t-tau lactoferrin decreased at borderline statistical significance. However, according pooled AUC, showed a significant predictive value salivary-based diagnosis. In conclusion, potential markers such as beta-amyloid42, tau can be detected saliva could reliably support early disease.

Language: Английский

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