Mechanisms of microbiota-gut-brain axis communication in anxiety disorders

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 9, 2024

Anxiety disorders, prevalent mental health conditions, receive significant attention globally due to their intricate etiology and the suboptimal effectiveness of existing therapies. Research is increasingly recognizing that genesis anxiety involves not only neurochemical brain alterations but also changes in gut microbiota. The microbiota-gut-brain axis (MGBA), serving as a bidirectional communication pathway between microbiota central nervous system (CNS), at forefront novel approaches deciphering complex pathophysiology disorders. This review scrutinizes role recent advancements MGBA concerning disorders through literature, emphasizing mechanisms via neural signals, endocrine pathways, immune responses. evidence robustly supports critical influence both development progression these Furthermore, this discussion explores potential therapeutic avenues stemming from insights, alongside challenges issues present realm. Collectively, our findings aim enhance understanding pathological foster improved preventative strategies for

Language: Английский

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Depressive rumination and trait anxiety mediate the effects of childhood victimization on adulthood depressive symptoms in adult volunteers

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(5), P. e0286126 - e0286126

Published: May 23, 2023

Background Prior studies have reported that childhood victimization experiences substantially augment the risk of depression and suicide in adulthood. Several our previous suggested interact with quality parenting experienced childhood, abuse, neuroticism, other factors to influence depressive symptoms In this study, it was hypothesized “childhood victimization” worsens “trait anxiety” “depressive rumination”, rumination” are mediators worsen adulthood”. Subjects methods The following self-administered questionnaires were completed by 576 adult volunteers: Patient Health Questionnaire-9, State–Trait Anxiety Inventory form Y, Ruminative Responses Scale, Childhood Victimization Rating Scale. Statistical analyses performed Pearson correlation coefficient analysis, t-test, multiple regression path covariance structure analysis. Results Path analysis demonstrated direct effect statistically significant for paths from trait anxiety, rumination, symptom severity. Moreover, indirect on rumination mediated anxiety significant. effects severity Furthermore, both Conclusions We found directly adversely influenced each above factors, indirectly worsened adulthood ruminations as mediating factors. present study is first clarify these mediation effects. Therefore, results suggest importance preventing identifying addressing patients clinical depression.

Language: Английский

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Assessment of memory deficits in psychiatric disorders: A systematic literature review

Journal of Neurosciences in Rural Practice, Journal Year: 2024, Volume and Issue: 15, P. 182 - 193

Published: April 12, 2024

Memory deficits are observed across psychiatric disorders ranging from the prodrome of psychosis to common mental such as anxiety, depression, and dissociative disorders. among patients recovering could be directly related primary illness or secondary adverse effect a treatment Electroconvulsive Therapy (ECT). The trouble in meaningful integration working-memory episodic memory is most commonly affected domain that requires routine assessments. An update on recent trends methods assessment first step towards understanding correcting these target optimum recovery. A systematic literature search was conducted October 2018 2022 review definition ‘Memory deficit’ operationalized ‘selective processes memory, required for activities daily living, resulting subjective distress dysfunction’. We included 110 studies, them being western countries with schizophrenia. Other dementia mild cognitive impairment. Brief Assessment Cognition Schizophrenia, Cambridge Automated Neuropsychological Test Battery, California Verbal Learning Test, Trail Making Part B, Rey Auditory Wechsler Scale, Adults Intelligence Scale-IV were neuropsychological assessments used. Mini-Mental State Examination Montreal Cognitive bedside tools used while Squire Subjective Questionnaire measure ECT-related deficits. highlights developments field Findings recommend emphasize developing especially severe illnesses. It remains interesting see role standardized diagnostic systems given more than decade research

Language: Английский

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Negative family and interpersonal relationship are associated with centromedial amygdala functional connectivity alterations in adolescent depression

European Child & Adolescent Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Language: Английский

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Jingqianshu granules mitigates premenstrual depression by regulating orexin signaling

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 14, 2024

Premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome (PMS), is serious health that affects patient moods. It caused by cyclic psychological symptoms and its pathogenesis still unclear. Abnormalities in the basolateral amygdala (BLA) orexin system, which are important causes development depressive mood, have not been reported PMDD, so exploring intrinsic mechanisms meaningful for enriching pathomechanisms PMDD.

Language: Английский

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Oral mucosal diseases and psychosocial factors: progress in related neurobiological mechanisms

Journal of International Medical Research, Journal Year: 2023, Volume and Issue: 51(12)

Published: Dec. 1, 2023

The aetiology of oral mucosal diseases, such as recurrent aphthous ulcer (RAU), lichen planus (OLP) and burning mouth syndrome (BMS), involves many factors, it remains difficult for clinicians to effectively relieve disease symptoms formulate coping strategies. With the rapid development psychology, role mental psychological factors in RAU, OLP BMS has gradually attracted researchers attention, but specific mechanism not been completely determined. This narrative review describes potential neurobiological diseases detailed after introducing relevant research into diseases. Future strategies innovations needed understand treat well how prevent by regulation neuroendocrine system, are also discussed.

Language: Английский

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Datura metel stramonium exacerbates behavioral deficits, medial prefrontal cortex, and hippocampal neurotoxicity in mice via redox imbalance

Laboratory Animal Research, Journal Year: 2023, Volume and Issue: 39(1)

Published: June 28, 2023

Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties. Hallucinations, confusion, agitation, aggressiveness, anxiety, and restlessness are reported amongst DM users. Earlier studies suggest that induces neurotoxicity affect brain physiology. However, the exact neurological effects of extract in medial prefrontal cortex (mPFC) hippocampal morphology have not been elucidated. In this study, we evaluated hypothesis oral exposure exerts neurotoxic effect increasing oxidative stress mPFC hippocampus behavioral deficits mice.DM methanolic significantly increased MDA NO levels reduced SOD, GSH, GPx CAT activities mice brains. addition, our results showed produced cognitive deficits, depressive-like behaviour following for 28 days. Moreover, neurodegenerative features, loss dendritic axonal arborization, dose-dependent decrease neuronal cell bodies' length, width, area, perimeter, increase distance between bodies.Oral behavioural degenerations via redox imbalance mice. These observations confirm extracts raises concerns on safety potential adverse humans.

Language: Английский

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Knowledge mapping of the relationship between norepinephrine and memory: a bibliometric analysis

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 25, 2023

Introduction Memory is a fundamental cognitive function for successful interactions with complex environment. Norepinephrine (NE) an essential component of catecholamine induced by emotional arousal, and numerous studies have demonstrated that NE key regulator in memory enhancement. We therefore conducted bibliometric analysis to represent the knowledge pattern literature on theme NE-memory relationship. Methods The WOSCC database was selected extract published during 2003-2022. collected data annual production, global cooperation, research structure hotspots were analyzed visualized. Results Our results showed links between displayed considerable development trend over last two decades. USA had leading position terms scientific outputs collaborations. Meanwhile, University California Irvine contributed most publications. Benno Roozendaal James McGaugh prolific authors this field, Neurobiology Learning highest number publications topic. emphasis has evolved from memory-related diseases brain regions neural mechanisms different types at circuit levels. Conclusion systematically perspective. mapping would provide valuable insights into landscape.

Language: Английский

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Mecanismos fisiopatológicos da depressão relacionados à perda de memória

Revista Neurociências, Journal Year: 2024, Volume and Issue: 32, P. 1 - 22

Published: Jan. 24, 2024

Introdução. A depressão é definida como uma doença psiquiátrica de caráter multifatorial que afeta mais 300 milhões pessoas e possui sintomas humor deprimido. Pode ser desencadeada eventos estressantes impactar significativamente algumas etapas fisiológicas da memória na evocação, velocidade processamento armazenamento associado a funcionalidades aberrantes hipocampais. Objetivo. Evidenciar os prejuízos relacionados aos aspectos emocionais cognitivos comprometem abordados partir anormalidades neurofisiológicas. Método. Revisão literatura integrativa elaborada por meio pesquisas utilizando as bases dados Scielo, PubMed, LILACS, BVS Science Direct, com seguintes descritores “Fisiologia” “Depressão” “Memória” no período 2018-2023 foram selecionados 26 artigos acordo o título, resumo, ano publicação, tipo estudo, idioma concordância tema. Resultados. revisão foi executada quanto à associação entre fisiopatologia perda memória, epidemiologia, fisiopatológico descrito várias facetas memória. Conclusão. Portanto, esse artigo aborda um tema extrema importância visto manifestações patológicas impacto neurocognitivo devido são relevantes impactam vida do indivíduo.

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Age-related reduction in anxiety and neural encoding of negative emotional memory

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: July 3, 2024

Introduction Older adults experience less anxiety. We examined how memory of negative emotional images varied with age and may reflect age-related differences in Methods Fifty-one adults, 22-80 years, underwent imaging a task where neutral were displayed pseudo-randomly. They queried post-scan about the inter-mixed an equal number never displayed. Sensitivity ( d’ ) reporting bias (Z-score false alarm rate; Z[FAR]) quantified signal detection theory. Results Age was negatively correlated both Spielberg State Trait Anxiety Inventory (STAI) state score (negative – neutral) positively Z[FAR] neutral). However, STAI or not significantly correlated. In whole-brain regression, higher activity right middle/superior temporal gyri/temporal parietal junction (MTG/STG/TPJ) for “negative correct incorrect” “neutral trials. Further, MTG/STG/TPJ (β) also age. Mediation analyses supported complete mediation model → anxiety β. Discussion Together, findings demonstrated changes reduction is reflected diminished temporoparietal cortical activities during encoding memory.

Language: Английский

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