Exposure profiles of social-environmental neighborhood factors and persistent distressing psychotic-like experiences across four years among young adolescents in the US

Psychological Medicine, Journal Year: 2025, Volume and Issue: 55

Published: Jan. 1, 2025

Abstract Background Recent research has demonstrated that domains of social determinants health (SDOH) (e.g. air pollution and context) are associated with psychosis. However, SDOHs have often been studied in isolation. This study investigated distinct exposure profiles, estimated their associations persistent distressing psychotic-like experiences (PLE), evaluated whether involvement physical activity partially explains this association. Methods Analyses included 8,145 young adolescents from the Adolescent Brain Cognitive Development Study. Data baseline three follow-ups were included. Area-level geocoded variables spanning various SDOH, including socioeconomic status, education, crime, built environment, context, clustered using a self-organizing map method to identify profiles. Generalized linear mixed modeling tested association between profiles PLE activities (i.e. team individual sports), adjusting for individual-level covariates age, sex, race/ethnicity, highest level parent family-relatedness, sites. Results Five identified. Compared reference Profile 1 (suburban affluent areas), 3 (rural areas low walkability high ozone), 4 (urban SES deprivation, pollution) greater PLE. Team sports mediated 6.14% 3. Conclusions found neighborhoods characterized by rural urban concentrations, crime Findings suggest social-environmental factors may differentially impact development

Language: Английский

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Neuroinflammation and schizophrenia – is there a link?

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

Keywords: inflammation, schizophrenia, biomarkers, psychiatric genetics, neurobiology, neuroinflammation, psychotic disorders

Language: Английский

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Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 3 - 15

Published: June 20, 2024

Language: Английский

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The influence of deprivation on cortical development and psychotic symptoms in youth

Journal of Child Psychology and Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Background People with early‐life experiences of deprivation are more likely to develop psychotic symptoms. While the mechanisms this relationship poorly understood, research suggests a role cortical development. Methods In 6323 youth from Adolescent Brain Cognitive Development study, we examined associations between total, material, interpersonal, cognitive and neighbourhood at age 9–11 years psychotic‐like (PLEs) 2 later. We then investigated whether were mediated by variation in volume baseline or rate change follow‐up. Sex‐specific effects throughout. Results All measures associated greater PLEs. Most these partially structure widespread regions, including lower ventral visual sensorimotor regions particularly females, steeper decline association areas. Conclusions Early‐life may be via disruption structure. This phenomenon is common several forms continues into early adolescence certain regions.

Language: Английский

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Admissions for psychosis following agency-notified child maltreatment at 40-year-follow-up: Results from the Childhood Adversity and Lifetime Morbidity (CALM) cohort

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 267, P. 247 - 253

Published: April 5, 2024

There is substantial evidence of an association between self-reported child maltreatment (CM) and subsequent psychosis in retrospective data. Such findings may be affected by recall bias. Prospective studies notifications to statutory agencies address bias but are less common subject attrition These therefore underpowered detect significant associations for some CM types such as sexual abuse. This study linked administrative health data a large birth cohort that included protection agencies. We assessed psychiatric outcomes measured inpatient admissions non-affective psychoses (ICD10 codes F20-F29) both public private hospitals Brisbane, Australia. Follow-up was up 40 years old. were 6087 participants whose could the Of these, 10.1 % had been notification. Seventy-two (1.2 %) admitted 40-year follow-up. On adjusted analysis, all notified substantiated associated with psychosis. neglect, physical, or emotional abuse, well multiple types. For instance, there 2.72-fold increase following any agency notification (95 CI = 1.53-4.85). All show age 40. Screening individuals who present is, therefore, indicated, greater awareness survivors at higher risk developing psychotic symptoms.

Language: Английский

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A Multidimensional Analysis of the Social Determinants of Psychotic-like Experiences

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Recent research has demonstrated that domains of social determinants health (SDOH) (e.g., air pollution and context) are associated with psychosis. However, SDOHs have often been studied in isolation.

Language: Английский

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Neuroendocrine Biomarkers

Published: Jan. 1, 2024

Schizophrenia spectrum disorders (SSD) pose complex challenges in mental health, with ongoing research exploring factors that influence their course. Emerging evidence suggests a role for hormonal the development and progression of SSD, making neuroendocrine biomarkers promising candidates constructing diagnostic models. This review spans past 12 years (2011–2023) focuses on use developing models, evaluated through receiver operating characteristic (ROC) curve analysis. A comprehensive screening nine articles involving seven countries over 3000 patients SSD was conducted. These emphasized efficacy predicting disease course individuals at clinical high risk psychosis or monitoring improvement during treatment. In general, models presented modest performance, area under (AUC) values ranging from 22% to 80%. However, one study distinguished itself by incorporating diverse array compound classes integrating scores derived CAARMS tool, which evaluates early signs symptoms psychosis. Impressively, this model achieved an AUC 90%. standout result underscores potential value broader range alongside assessments enhancing predictive accuracy SSD.

Language: Английский

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Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 16, 2024

Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs FEP on CT remain understudied. One-hundred sixteen individuals with (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) 98 healthy controls (HCs) 24.4 6.2 43% females) reported the presence/absence CA <17 years using an adapted version Childhood Experience Care Abuse (CECA.Q) Retrospective Bullying Questionnaire (RBQ) underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used assess associations brain maps effects. General linear models (GLMs) performed interaction CT. Eighty-three 83 HCs exposure at least one CA. similar those found participants exposed separation from parents, bullying, parental discord, household poverty, sexual abuse (r 0.50 0.25). Exposure neglect (β -0.24, 95% CI [-0.37 -0.12], p 0.016) overall maltreatment -0.13, [-0.20 -0.06], 0.043) associated thinning right medial orbitofrontal region. Cortical are observed context socio-environmental adversity. Neglect may contribute reductions FEP. Our findings provide new insights into specific neurobiological early psychosis.

Language: Английский

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Dimensional early life adversity and anxiety symptoms: A network analysis and longitudinal study

Child Abuse & Neglect, Journal Year: 2024, Volume and Issue: 160, P. 107201 - 107201

Published: Dec. 27, 2024

Language: Английский

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