ds-FCRN: three-dimensional dual-stream fully convolutional residual networks and transformer-based global–local feature learning for brain age prediction

Brain Structure and Function, Journal Year: 2025, Volume and Issue: 230(2)

Published: Jan. 18, 2025

Language: Английский

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No Causal Links Between Lifetime Estradiol Exposure and Female’s Brain and Mental Health – A Mendelian Randomization Study

Published: July 30, 2024

Estradiol, the predominant sex steroid in females, has been implicated development of depression and Alzheimer’s disease – two disorders that disproportionately affect females. Yet, while some studies suggest protective effects estradiol on brain health mental health, results are inconsistent partly due to methodological challenges observational such as confounding reverse causation. In this preregistered study, we examined whether levels factors related lifetime exposure causally linked age gap (predicted relative chronological age), AD risk, risk The included reproductive span, at menarche, menopause, number childbirths, oral contraceptive use, HRT history hysterectomy, oophorectomy. To overcome studies, tested for causal associations by conducting two-sample Mendelian randomization analyses using female-specific summary statistics from previously conducted newly run genome-wide association (GWAS). This running first GWAS a levels. No significant were found between levels, or any gap, AD, depression. Therefore, do not support links with Future should assess other influencing factors, well implement sex-specific, frameworks examine potential hormonal fluctuations periods increased susceptibility steroids perimenopausal period.

Language: Английский

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The Transition to Parenthood: Linking Hormones, Brain, and Behavior

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 172, P. 107247 - 107247

Published: Nov. 22, 2024

Language: Английский

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