Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes

BMJ Open Diabetes Research & Care, Journal Year: 2025, Volume and Issue: 13(1), P. e004396 - e004396

Published: Jan. 1, 2025

Depression is associated with diabetes, but the underlying causes remain unclear. To better understand depression in this study investigated associations between 135 inflammatory and neurological protein biomarkers depressive symptoms individuals diabetes.This cross-sectional included 430 adults a known diabetes duration <1 year from German Diabetes Study (GDS), whom were measured serum evaluated at baseline annually over 5 years using Center for Epidemiological Studies Scale (CES-D). Based on information follow-up visits (n=305, ≥3 time points), we subdivided sample into persistent or recurrent transient never symptoms. We assessed of each biomarker CES-D score (continuous) persistent/recurrent multiple linear logistic regression models, respectively.After adjustment covariates, identified three-protein signature CUB domain-containing 1 (CDCP1) NAD-dependent deacetylase sirtuin-2 (SIRT2) positively (β 1.24 (95% CI 0.19 to 2.29); β 0.89 0.06 1.72)), respectively) (OR 1.58 1.08 2.31); OR 1.32 1.03 1.71), respectively), whereas leptin receptor (LEPR) was inversely -0.99 -1.87 -0.11)) 0.70 0.49 0.99)). However, results not significant after testing.In conclusion, may provide insights mechanisms might open new therapeutic avenues.The trial registration number NCT01055093.

Language: Английский

Translational perspectives of endocrine alterations in psychosis: Are we there yet?

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 176, P. 107419 - 107419

Published: March 5, 2025

Language: Английский