Microbiome Research Reports, Journal Year: 2025, Volume and Issue: 4(2)
Published: April 17, 2025
The initial gut colonization of the infant plays a pivotal role in shaping immune system, developing intestinal tract, and influencing host metabolism, all which are strongly influenced by several determinants, such as gestational age at birth, mode delivery, neonatal feeding practices, early-life stress (ELS), exposure to perinatal antibiotics. However, resulting microbiome (GM) dysbiosis may alter this developmental programming, leading long-term adverse health outcomes. This narrative review synthesizes current knowledge on GM development its impact health. Specifically, it addresses how affect trajectory physiological processes, predisposing individuals conditions allergic diseases, metabolic disorders, type 1 diabetes, inflammatory bowel atherosclerotic cardiovascular diseases. In addition, examines influence probiotic prebiotic supplementation during pregnancy early life composition, well ELS-induced mental Recent research suggests that microbiota initiates long-lasting effects, inadequate or insufficient microbial triggers responses associated with conditions. Although studies have reported connection between ELS both prenatal postnatal periods, unified signature linked either remains be fully elucidated. Thus, future needed establish causality determine whether modifiable factors affecting could targeted improve health, especially children exposed contextual
Language: Английский