Accelerometer-Derived Sleep Metrics in Adolescents Reveal Shared Genetic Influences with Obesity and Stress in a Brazilian Birth Cohort Study DOI Creative Commons
Marina Xavier Carpena,

Karen Sánchez,

Mariana Otero Xavier

et al.

SLEEP, Journal Year: 2024, Volume and Issue: 48(1)

Published: Oct. 29, 2024

We aimed to test the association between sleep-related polygenic scores (PGSs) and accelerometer-based sleep metrics among Brazilian adolescents evaluate potential mechanisms underlying through enrichment of obesity, cortisol pathway-specific (PRSet). Utilizing data from The 2004 Pelotas (Brazil) Birth Cohort, time window efficiency were measured at 11-year-old follow-up using ActiGraph accelerometers. Three PGSs developed based on most recent genome-wide study measures. PRSet, calculated variants linked body mass index (BMI) plasmatic concentration, assess pleiotropic effects. Linear regression models, adjusted for sex first 10 principal components ancestry, employed explore impact PGS specific-PRSet phenotypes. number nocturnal episodes-PGS was positively associated with (β = 2.306, SE: 0.92, p .011). Nocturnal episodes also when restricted BMI-PRSet 2.682, 0.912, competitive .003). Both cortisol-PRSets .002, 0.001, .013; β .003, respectively) exhibited in molecular pathways (competitive .011; efficiency. Sleep polygenetic observed European adults may partially explain adolescents. Specific BMI strengthened window, while concentration pathway had a significant genetic liability Our results suggest overlap as etiological comorbidities, emphasizing common mechanisms.

Language: Английский

Diabetes in China: epidemiology, pathophysiology and multi-omics DOI
Weiping Jia, Juliana C.N. Chan, Tien Yin Wong

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

2
Exploring Social-Ecological Pathways From Sexual Identity to Sleep Among Chinese Women: Structural Equation Modeling Analysis DOI Creative Commons
Chanchan Wu, Pui Hing Chau, Edmond Pui Hang Choi

et al.

JMIR Public Health and Surveillance, Journal Year: 2025, Volume and Issue: 11, P. e53549 - e53549

Published: Jan. 21, 2025

Women and sexual minority individuals have been found to be at higher risk for experiencing poor sleep health compared their counterparts. However, research on the of women (SMW) is lacking in China. This study aimed examine quality social support Chinese with varied identities, then investigate in-depth relationships between identity sleep. was a cross-sectional web-based survey. All participants completed structured questionnaire containing set sociodemographic items referring social-ecological model health, Pittsburgh Sleep Quality Index, Social Support Rating Scale, environment domains World Health Organization Life-abbreviated short version. Pearson correlation coefficients were used relationship as well two life. Structural equation modeling analysis explore relationships. A total 250 cisgender heterosexual (CHW) 259 SMW recruited from July September 2021. 241 (47.3%) experienced rate significantly than CHW (55.2% vs 39.2%, P<.001). Around one-fifth reported low levels support, which that (21.6% 5.6%, correlations showed overall negatively associated weak (r=-0.26, The final structural satisfactory fit indices identified 6 pathways, showing alcohol use, objective utilization perceived life played important roles identity. poorer CHW. Further recommended address modifiable factors affecting implement tailored improvement programs.

Language: Английский

Citations

0
Annual medical expenditure associated with short sleep in China: estimates from a nationally representative sample DOI Creative Commons
Xumeng Yan, Fang Han, Ichiro Kawachi

et al.

SSM - Population Health, Journal Year: 2025, Volume and Issue: unknown, P. 101808 - 101808

Published: April 1, 2025

Language: Английский

Citations

0
A translation and validation study of the traditional Chinese version of RU-SATED scale in Chinese Hong Kong residents DOI
Jiayin Ruan, Wing‐Fai Yeung, Branda Yee‐Man Yu

et al.

Sleep Health, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes DOI Creative Commons
X. Ma,

Xingqiang Pan,

Miao Xu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 13, 2025

The aim of this study was to investigate the association between persistent nocturnal sleep duration patterns and carotid intima-media thickness (CIMT) in Chinese patients with type 2 diabetes mellitus (T2DM). From March 1, 2018 August 31, 2023, a cross-sectional carried out at National Metabolic Management Center First Affiliated Hospital Ningbo University. Each patient completed minimum three questionnaire assessments during period. Group-based trajectory modeling employed identify distinct groups exhibiting different trajectories duration. CIMT ≥ 1 mm used assess early atherosclerotic changes arterial structure. Multiple logistic regression CIMT. Three were identified: short (6.44 h: n = 114, 13.5% all subjects), moderate (7.59 500, 59.0%), long (8.69 233, 27.5%). After adjusting for age, sex, education, body mass index, physical activity, current smoking, alcohol drinking, hypertension, hyperlipidemia, HbA1c, odds found be higher (OR 3.03, 95%CI 1.15, 7.98). However, no significant night mm. Persistent associated increased T2DM. Further longitudinal studies are warranted fully elucidate topic.

Language: Английский

Citations

0
Novel perspective of ‘poor sleep’ in public health: a narrative review DOI Creative Commons
Damien Léger, Luigi Ferini‐Strambi, Fang Han

et al.

BMJ Public Health, Journal Year: 2024, Volume and Issue: 2(2), P. e000952 - e000952

Published: Sept. 1, 2024

A high percentage of people worldwide complain sleep disturbances; however, the vast majority do not meet diagnostic criteria for insomnia or other classic disorders. Therefore, 'classical' concept poor remains undetected, and patients stay ignored unidentified. Also, has been strongly associated with increased daytime function impairment, morbidity mortality is considered a risk factor developing mental Poor individual experience insufficient restorative and/or satisfaction in adults who fulfil This article provides review on impact healthy life within multidimensional health, including COVID-19-affected period. We propose wide definition key characteristics sleepers tools (self) detection. discuss assessment methods that combine ability to capture subjective perception measure objective parameters. then report selected strategies improve focusing habits, cognitive behavioural therapy, diet, exercise, food supplements aids. Considering current megalopolis way life, young are following 24/24 hours 7 days/week rhythm exposure noise light pollution, night-shift work, higher commute time, global temperature overuse smartphones screens. there an urgent need increasing awareness stimulating educational efforts targeted at primary care specialists.

Language: Английский

Citations

1
Construction and verification of the prediction model for risk of sleep disturbance in elderly patients with hypertension: a cross-sectional survey based on NHANES database from 2005 to 2018 DOI Creative Commons
Lixiang Zhang, Tingting Wang, Ying Jiang

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 19, 2024

To construct and verify a risk prediction model for sleep disturbance in elderly patients with hypertension, aiming to offer guidance management this demographic.

Language: Английский

Citations

0
Accelerometer-Derived Sleep Metrics in Adolescents Reveal Shared Genetic Influences with Obesity and Stress in a Brazilian Birth Cohort Study DOI Creative Commons
Marina Xavier Carpena,

Karen Sánchez,

Mariana Otero Xavier

et al.

SLEEP, Journal Year: 2024, Volume and Issue: 48(1)

Published: Oct. 29, 2024

We aimed to test the association between sleep-related polygenic scores (PGSs) and accelerometer-based sleep metrics among Brazilian adolescents evaluate potential mechanisms underlying through enrichment of obesity, cortisol pathway-specific (PRSet). Utilizing data from The 2004 Pelotas (Brazil) Birth Cohort, time window efficiency were measured at 11-year-old follow-up using ActiGraph accelerometers. Three PGSs developed based on most recent genome-wide study measures. PRSet, calculated variants linked body mass index (BMI) plasmatic concentration, assess pleiotropic effects. Linear regression models, adjusted for sex first 10 principal components ancestry, employed explore impact PGS specific-PRSet phenotypes. number nocturnal episodes-PGS was positively associated with (β = 2.306, SE: 0.92, p .011). Nocturnal episodes also when restricted BMI-PRSet 2.682, 0.912, competitive .003). Both cortisol-PRSets .002, 0.001, .013; β .003, respectively) exhibited in molecular pathways (competitive .011; efficiency. Sleep polygenetic observed European adults may partially explain adolescents. Specific BMI strengthened window, while concentration pathway had a significant genetic liability Our results suggest overlap as etiological comorbidities, emphasizing common mechanisms.

Language: Английский

Citations

0