Impact of the COVID-19 Pandemic on Allergy Indicators in Adults: A Retrospective Study from 2018 to 2023 DOI Creative Commons
Junkang Chen,

Yena Gu,

Zhexuan Yu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract This study aimed to assess the impact of COVID-19 pandemic on allergy indicators in adult patients. We analyzed 8015 tIgE and 34,163 allergen detection results from 2018 2023. Patients were categorized into pre-pandemic (2018–2019), pandemic-period (2020–2022), post-pandemic (2023) groups. Group comparisons logistic regression analyses examined relationship between relevant factors positivity rates. Inverse probability treatment weighting (IPTW) using propensity scores was applied address baseline imbalances. The findings demonstrated consistent conclusions for both detection. rates levels significantly lower during after compared period. Univariate multivariate revealed that periods associated with a reduced risk positivity, period exhibiting more pronounced effect. After IPTW adjustment, tIgE, (OR = 0.436 0.465, respectively; P < 0.001). For related detection, 0.733 0.817, markedly enhanced adults, potentially attributed lifestyle modifications.

Language: Английский

Association between underlying health conditions and long COVID among non-hospitalized and hospitalized individuals as modified by health literacy: A multi-center study DOI Creative Commons
Han Thi Vo,

Thang Viet Dao,

Xuan Tinh

et al.

Public Health, Journal Year: 2025, Volume and Issue: 239, P. 87 - 93

Published: Jan. 10, 2025

We investigated the effect modification of health literacy (HL) in ameliorating negative impact underlying conditions (UHC) on long COVID among non-hospitalized and hospitalized survivors. An online cross-sectional study was conducted Vietnam from December 2021 to October 2022. A sample 4507 participants recruited 18 hospitals centers were those aged or older, had contracted COVID-19 for at least 28 days, not acute phase reinfection. Participants reported their symptoms, UHC, literacy, socio-demographics, clinical parameters, battery disability scale, health-related behaviors. The logistic regression models used examine associations interactions. Underlying associated with a higher likelihood (adjusted odds ratio, aOR = 2.10 [1.61, 2.61]; p < 0.001), ones (aOR 2.26 [1.87, 2.73]; 0.001). In participants, HL scores significantly linked reduced experiencing 0.96 [0.95, 0.97]; Furthermore, moderated adverse this group 0.97 [0.94-0.99]; 0.042). although also lower risk 0.99 [0.98-0.99]; 0.036), did mitigate UHC 1.01 [0.99-1.03]; 0.332). individuals, high ameliorated COVID. Such effects observed

Language: Английский

Citations

0
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication DOI Open Access
Paul J. Baker, Andrea C. Bohrer, Ehydel Castro

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 27, 2024

SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from asymptomatic fatal disease. Co-morbidities, sex, age, host genetics and vaccine status are known affect disease severity. Yet, how the inflammatory milieu of lung at time exposure impacts control viral replication remains poorly understood. We demonstrate here that immune events in mouse closely preceding significantly impact we identify key innate pathways required limit replication. A diverse set pulmonary stimuli, including resolved antecedent respiratory infections with

Language: Английский

Citations

2
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication DOI Open Access
Paul J. Baker, Andrea C. Bohrer, Ehydel Castro

et al.

Science Immunology, Journal Year: 2024, Volume and Issue: 9(102)

Published: Dec. 6, 2024

Severity of COVID-19 is affected by multiple factors; however, it not understood how the inflammatory milieu lung at time SARS-CoV-2 exposure affects control viral replication. Here, we demonstrate that immune events in mouse closely preceding infection affect and identify innate pathways limit Pulmonary stimuli including resolved, antecedent respiratory infections with Staphylococcus aureus or influenza, ongoing pulmonary Mycobacterium tuberculosis infection, ovalbumin/alum-induced asthma, airway administration TLR ligands recombinant cytokines all establish an antiviral state restricts In addition to type I interferons, TNFα IL-1 potently precondition for enhanced control. Our work shows may benefit from immunologically quiescent microenvironment suggests heterogeneity inflammation contribute variability disease outcomes.

Language: Английский

Citations

2
Asthma as a risk factor and allergic rhinitis as a protective factor for COVID-19 severity: a case-control study DOI

Martha Débora Lira Tenório,

Gabriel Valentim dos Santos Menezes Siqueira,

Gustavo Costa Caldas

et al.

European Archives of Oto-Rhino-Laryngology, Journal Year: 2024, Volume and Issue: 281(12), P. 6677 - 6686

Published: Aug. 24, 2024

Language: Английский

Citations

0
Impact of the COVID-19 Pandemic on Allergy Indicators in Adults: A Retrospective Study from 2018 to 2023 DOI Creative Commons
Junkang Chen,

Yena Gu,

Zhexuan Yu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract This study aimed to assess the impact of COVID-19 pandemic on allergy indicators in adult patients. We analyzed 8015 tIgE and 34,163 allergen detection results from 2018 2023. Patients were categorized into pre-pandemic (2018–2019), pandemic-period (2020–2022), post-pandemic (2023) groups. Group comparisons logistic regression analyses examined relationship between relevant factors positivity rates. Inverse probability treatment weighting (IPTW) using propensity scores was applied address baseline imbalances. The findings demonstrated consistent conclusions for both detection. rates levels significantly lower during after compared period. Univariate multivariate revealed that periods associated with a reduced risk positivity, period exhibiting more pronounced effect. After IPTW adjustment, tIgE, (OR = 0.436 0.465, respectively; P < 0.001). For related detection, 0.733 0.817, markedly enhanced adults, potentially attributed lifestyle modifications.

Language: Английский

Citations

0