Air Pollution-Linked Epigenetic Modifications in Placental DNA: Prognostic Potential for Identifying Future Foetal Anomalies DOI

Sruthy Hari Kumar,

Sayanti Acharyya,

Apoorva Chouksey

et al.

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 129, P. 108675 - 108675

Published: July 27, 2024

Language: Английский

Temporal trends of particulate matter pollution and its health burden, 1990–2021, with projections to 2036: a systematic analysis for the global burden of disease study 2021 DOI Creative Commons
Tao Fang,

Yanbo Di,

Xu Yang

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 16, 2025

Particulate matter pollution (PM2.5) is a leading global health risk factor. We analyzed the spatiotemporal trends of diseases attributable to PM2.5 at global, regional, and national levels from 1990 2021. Using data Global Burden Disease (GBD) 2021 study, we assessed deaths disability-adjusted life years (DALYs) due PM2.5, along with age-standardized mortality rates (ASMR) DALY (ASDR), categorized by age, sex, year, location, disease type. used average annual percentage change (AAPC) illustrate Spearman correlation analysis was conducted examine relationship between socio-demographic index (SDI) (ASRs) across 204 countries. Bayesian age-period-cohort (BAPC) project for 2022-2036. In 2021, exposure contributed 7.83 million 231.51 DALYs globally. The decreased 95.69 per 100,000 (AAPC = -2.12) 2984.47 -2.22), compared 1990. burdens related as reflected ASMR ASDR, declined SDI quintiles GBD super regions low quintile had highest burden (ASMR: 211.39, ASDR: 6,114.26). Correlation revealed significant negative ASRs SDI. South Asia sub-Saharan Africa experienced burdens. Males higher than females globally in all regions. particularly severe children under five older adults. Ischemic heart stroke were causes PM2.5-related DALYs. Diabetes mellitus saw an increase both BAPC model predicts continued declines ASDR over next 15 years. With population growth aging demographic, public associated remains major concern. It imperative develop targeted proactive strategies that account unique circumstances challenges different

Language: Английский

Citations

0

PM2.5 Components and Fetal Chromosomal Abnormalities: Identifying Critical Exposure Windows DOI
Xiaozhou Li, Yuqi Guo, Deyan Wu

et al.

Environmental Science & Technology Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Language: Английский

Citations

0

PM2.5 constituent exposures and maternal circulatory homocysteine in early pregnancy DOI Creative Commons
Xuesong Li,

Mingyang Ran,

Mengyuan Wang

et al.

Environmental Health, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 7, 2025

Elevated homocysteine (Hcy) is a pathogenic mechanism of adverse pregnancy outcomes and PM2.5–induced cardiovascular diseases. We investigated the associations fine particulate matter (PM2.5) chemical constituent exposures with maternal circulatory Hcy in early pregnancy. Serum 5-methyltetrahydrofolate 324 women (162 normal [NEP] 162 loss [EPL]) were measured by ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry. Daily to PM2.5 constituents (black carbon [BC], organic matter, nitrate, ammonium, sulfate) accessed using data Tracking Air Pollution China platform. Nonlinear linear average pollutant during post-conception period serum estimated generalized additive models multivariable regression models, respectively. Weekly cumulative distributed lag between within three months before collection analyzed nonlinear combined models. Sensitivity analyses conducted residuals instead concentrations. Three–month five associated elevated all participants, EPL group, NEP 3–12 weeks being susceptible exposure time windows. Pollutants–related generally higher group than group. Higher PM2.5, BC, sulfate increased lower but not subgroup. Sulfate was highest risk residual–related Hcy. BC both three–month periods Maternal exposures, constituent. BC–related may induce EPL. The study protocol registered for clinical trials (ChiCTR1900028619) on December 29, 2019.

Language: Английский

Citations

0

Exposure to low concentrations of PM2.5 and its constituents with preterm birth in Shenzhen, China: a retrospective cohort study DOI Creative Commons
Minting Zhu,

Zhongai Ouyang,

Tao Liu

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 7, 2025

Abstract Background Due to the Air Pollution Prevention and Control Measures issued by Chinese government, air quality has significantly improved, particularly with respect PM 2.5 . However, studies on relationship between low concentrations of preterm birth (PTB) remain limited in China. Objective To examine associations its constituents PTB. Methods This retrospective cohort study was conducted from July 2021 April 2023 Shenzhen, Data questionnaires pregnancy outcomes were collected for each participant. Using Tracking China (TAP) dataset, we assessed chemical constituents, including sulfate (SO 4 2− ), nitrate (NO 3 − organic matter (OM), black carbon (BC), ammonium (NH + ). We applied a generalized additive model (GAM) evaluate relationship. The exposure PTB further examined using method that combined dummy variable settings trend tests. Stratified analysis explore potential factors. Results Among 17,240 live-born infants, rate 6.0%, average concentration 20.24 μg/m There positive With interquartile range (IQR) increase during third trimester, risk increased 2.23 times. effects ) (OM) comparable total trimester might be critical susceptibility window. higher among women who conceived cold season exposed temperatures pregnancy. Conclusion Even at levels, can still PTB, varying health attributed different constituents. underscores importance strengthening environmental management characterizing contributions sources.

Language: Английский

Citations

0

Associations of air pollutants and related metabolites with preterm birth during pregnancy DOI Creative Commons

Liuyan Zheng,

Jungu Zhou,

Li Zhu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175542 - 175542

Published: Aug. 14, 2024

This study aimed to investigate the influence of exposure ambient fine particulate matter (PM

Language: Английский

Citations

3

Seasonal variation in exposure to particulate matter among children attending different levels of education: Comparison of two dosimetry models DOI Creative Commons

Isabella Charres,

Yago Alonso Cipoli, Leonardo Furst

et al.

Atmospheric Pollution Research, Journal Year: 2024, Volume and Issue: 15(9), P. 102229 - 102229

Published: June 17, 2024

Exposure to particulate matter (PM) has been associated with several adverse health outcomes. Studies indicate that children may be exposed much higher concentrations of PM at school than in other environments. There exists very little data on the deposited dose while attend classes. This study was carried out a located near an industrial complex Portugal and attended by aged 3–12 years. Indoor PM10, PM2.5 PM1 were measured over two seasons classrooms representing different year groups. Particle deposition fractions respiratory tract, as well doses, calculated using Multiple-Path Dosimetry (MPPD) Dose Model (ExDoM2). Both models implemented assuming 8-h exposure scenario represent day. In general, differences observed depending room occupancy periods season. The highest mean concentration recorded winter when classroom vacant (23.7 ± 20.5 μg m−3), PM10 level spring during hours (61.7 24.2 m−3). Regardless dosimetry model, upper region, lowest tracheobronchial (TB) region. results fraction more harmful pupils' winter. presented ranging from 54.2 128 83.9 185 μg, according MPPD ExDoM2 estimates, respectively.

Language: Английский

Citations

2

The relationship between air pollutants and preterm birth and blood routine changes in typical river valley city DOI Creative Commons
Jimin Li,

Jiajia Gu,

Lang Liu

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 24, 2024

Abstract Objective To collect maternal maternity information on preterm births in two tertiary hospitals the urban area of Baota District, Yan'an City, from January 2018 to December 2020, explore long-term and short-term effects air pollutants (PM 2.5 , PM 10 SO 2 NO CO O 3 ) births, changes blood cell counts due pollutants. Methods Daily average mass concentration data six City 1, 2017 31, 2020 were collected monitoring station City. Meteorological was obtained Bureau including temperature,relative humidity wind speed for time period. The each exposure window pregnant women assessed by nearest method, conditional logistic regression used analyze relationship between as well lagged cumulative Multiple linear tests after stepwise determine confounders test. Results showed that risk factors birth. In two-pollutant model, mixed with other associated effect NO, birth; except correlation study indicators correlated leukocytes, monocytes, basophils, erythrocytes, hs-CRPand not CRP. Conclusion Exposure is a factor basophils erythrocytes hs-CRP.

Language: Английский

Citations

1

Air Pollution-Linked Epigenetic Modifications in Placental DNA: Prognostic Potential for Identifying Future Foetal Anomalies DOI

Sruthy Hari Kumar,

Sayanti Acharyya,

Apoorva Chouksey

et al.

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 129, P. 108675 - 108675

Published: July 27, 2024

Language: Английский

Citations

1