Molecular Diversity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 24, 2024
Abstract
Pyroptosis,
as
a
lytic-inflammatory
type
of
programmed
cell
death,
has
garnered
considerable
attention
due
to
its
role
in
cancer
chemotherapy
and
many
inflammatory
diseases.
This
review
will
discuss
the
biochemical
classification
pyroptotic
inducers
according
their
chemical
structure,
mechanism,
these
targets.
A
structure-activity
relationship
study
on
is
revealed
based
surveyed
inducer
chemotherapeutics.
The
shared
features
structures
current
agents
were
displayed,
including
an
essential
cyclic
head,
vital
linker,
hydrophilic
tail
that
significant
for
π-π
interactions
hydrogen
bonding.
presented
structural
open
way
design
new
hybridized
classes
or
scaffolds
potent
future,
which
may
represent
solution
apoptotic-resistance
dilemma
along
with
synergistic
chemotherapeutic
advantage.
Graphical
Cells,
Journal Year:
2023,
Volume and Issue:
12(13), P. 1787 - 1787
Published: July 5, 2023
Immunotherapy
includes
immune
checkpoint
inhibitors
(ICI)
such
as
antibodies
targeting
cytotoxic
T-lymphocyte-associated
protein
4
(CTLA-4)
or
the
programmed
cell
death
protein/programmed
ligand
1
(PD-1/PD-L1)
axis.
Experimental
and
clinical
evidence
show
that
immunotherapy
based
on
provides
long-term
survival
benefits
to
cancer
patients
in
whom
other
conventional
therapies
have
failed.
However,
only
a
minority
of
high
via
use
ICI
alone.
One
major
factors
limiting
can
be
attributed
lack
infiltration
within
tumor
microenvironment.
Such
tumors
are
classified
“cold/warm”
an
“desert”;
those
displaying
significant
considered
“hot”
inflamed.
This
review
will
provide
brief
summary
different
properties
contributing
establishment
cold
describe
strategies
could
reprogram
non-inflamed
into
inflamed
hot
tumors.
More
particularly,
we
how
hypoxia
induce
metabolic
reprogramming
results
improving
extending
benefit
ICI.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(9)
Published: Sept. 1, 2024
Abstract
Cell
death
regulation
is
essential
for
tissue
homeostasis
and
its
dysregulation
often
underlies
cancer
development.
Understanding
the
different
pathways
of
cell
can
provide
novel
therapeutic
strategies
battling
cancer.
This
review
explores
several
key
mechanisms
apoptosis,
necroptosis,
autophagic
death,
ferroptosis,
pyroptosis.
The
research
gap
addressed
involves
a
thorough
analysis
how
these
be
precisely
targeted
therapy,
considering
tumor
heterogeneity
adaptation.
It
delves
into
genetic
epigenetic
factors
signaling
cascades
like
phosphatidylinositol
3‐kinase/protein
kinase
B/mammalian
target
rapamycin
(PI3K/AKT/mTOR)
mitogen‐activated
protein
kinase/extracellular
signal‐regulated
(MAPK/ERK)
pathways,
which
are
critical
death.
Additionally,
interaction
microenvironment
with
cells,
particularly
influence
hypoxia,
nutrient
deprivation,
immune
cellular
interactions,
explored.
Emphasizing
strategies,
this
highlights
emerging
modulators
inducers
such
as
B
lymphoma
2
(BCL2)
homology
domain
3
(BH3)
mimetics,
tumour
necrosis
factor‐related
apoptosis‐inducing
ligand
(TRAIL),
chloroquine,
innovative
approaches
to
induce
ferroptosis
provides
insights
therapy's
future
direction,
focusing
on
multifaceted
circumvent
drug
resistance.
examination
evolving
underlines
considerable
clinical
potential
continuous
necessity
in‐depth
exploration
within
scientific
domain.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(5), P. 1871 - 1883
Published: Jan. 1, 2024
Radiotherapy
(RT)
stands
as
the
primary
treatment
for
tumors,
but
it
inevitably
causes
damage
to
normal
cells.Consequently,
radiation
injury
is
a
crucial
consideration
oncologists
during
therapy
planning.Cell
death
including
apoptosis,
autophagy,
pyroptosis,
ferroptosis,
and
necroptosis
play
significant
roles
in
tumor
treatment.While
previous
studies
elucidated
induction
of
apoptosis
autophagy
by
ionizing
(IR),
recent
attention
has
shifted
necroptosis,
revealing
their
effects
induced
IR.This
review
aims
summarize
strategies
employed
IR,
either
alone
or
combination
therapy,
induce
injury.Furthermore,
we
explore
molecular
pathways,
shedding
light
on
injury.Finally,
regulative
agents
these
three
types
cell
mechanisms.In
summary,
optimizing
dose,
dose
rate,
combined
plans
minimize
enhance
killing
effect
RT
key
focus.
International Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
64(6)
Published: May 9, 2024
Hepatocellular
carcinoma
(HCC),
one
of
the
leading
causes
cancer‑related
mortality
worldwide,
is
challenging
to
identify
in
its
early
stages
and
prone
metastasis,
prognosis
patients
with
this
disease
poor.
Treatment
options
for
HCC
are
limited,
even
radical
treatments
being
associated
a
risk
recurrence
or
transformation
short
term.
Furthermore,
multi‑tyrosine
kinase
inhibitors
approved
first‑line
therapy
have
marked
drawbacks,
including
drug
resistance
side
effects.
The
rise
breakthrough
immune
checkpoint
(ICIs)
provided
novel
direction
immunotherapy
but
these
drawback
low
response
rates.
Since
avoiding
apoptosis
universal
feature
cancer,
induction
non‑apoptotic
regulatory
cell
death
(NARCD)
strategy
immunotherapy.
At
present,
NARCD
pathways,
ferroptosis,
pyroptosis
necroptosis,
potential
forms
immunogenic
death,
which
synergistic
effects
antitumor
immunity,
transforming
'cold'
tumors
into
'hot'
exerting
Therefore,
pathways
may
be
targeted
as
treatment
HCC.
In
present
review,
roles
necroptosis
immunity
discussed,
relevant
targets
signaling
current
status
combined
ICIs
summarized.
prospects
targeting
also
considered.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
33, P. 30 - 45
Published: Nov. 7, 2023
Cancer
remains
a
significant
global
health
concern,
necessitating
the
development
of
innovative
therapeutic
strategies.
This
research
paper
aims
to
investigate
role
pyroptosis
induction
in
cancer
treatment.
Pyroptosis,
form
programmed
cell
death
characterized
by
release
pro-inflammatory
cytokines
and
formation
plasma
membrane
pores,
has
gained
attention
as
potential
target
for
therapy.
The
objective
this
study
is
provide
comprehensive
overview
current
understanding
its
discusses
concept
relationship
with
other
forms
death,
such
apoptosis
necroptosis.
It
explores
immune
activation
combination
also
reviews
use
natural,
biological,
chemical,
multifunctional
composite
materials
cells.
molecular
mechanisms
underlying
these
are
discussed,
along
their
advantages
challenges
findings
highlight
novel
strategy
treatment
insights
into
different
involved
induction.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 24, 2025
Radiotherapy
(RTx)
is
a
highly
effective
treatment
for
head
and
neck
cancer
that
can
cause
concurrent
damage
to
surrounding
healthy
tissues.
In
cases
of
nasopharyngeal
carcinoma
(NPC),
the
auditory
apparatus
inevitably
exposed
radiation
fields
sustains
considerable
damage,
resulting
in
dysfunction.
To
date,
little
research
has
been
conducted
on
changes
induced
by
RTx
middle
ear
underlying
mechanisms
involved.
Dexamethasone
(DEX)
widely
used
clinical
practice
because
its
immunosuppressive
anti-inflammatory
properties.
The
present
study
investigated
effects
DEX
delivered
via
intratympanic
administration
RTx-induced
human
epithelial
(HMEE)
cells.
Sprague–Dawley
(SD)
rats
were
fractionated
(6.6
Gy/day
5
days),
samples
collected
at
1
4
months.
Rats
received
presented
significant
increase
thickness
submucosal
layer
disorganization
ciliated
epithelium
Eustachian
tube
(ET)
mucosa.
Importantly,
30
min
before
resulted
lower
degree
than
control
group.
Furthermore,
pretreatment
downregulated
expression
cell
death
pathway
markers
HMEE
Our
collective
results
potentially
support
use
reduce
radiation-induced
may
contribute
development
future
studies.
