Biocatalytic Strategies for Nitration Reactions DOI Creative Commons
Xiling Wang, Matteo Aleotti, Mélanie Hall

et al.

JACS Au, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Nitro compounds are key synthetic intermediates used as enabling tools in synthesis and found a large range of essential compounds, including pharmaceuticals, pesticides, various organic dyes. Despite recent methodological developments, the industrial preparation nitro still suffers from harsh reaction conditions, along with poor selectivity problematic environmental footprint. Although biological enzymatic methods exist, mild approaches for bionitration underexplored. Enzymes, their exquisite compatibility have potential to revolutionize way prepared. In this perspective, we systematically analyze currently available biological/enzymatic methods, oxidation an amine precursor or consisting direct oxidative nitration non-oxidative nitration. By examining both scope mechanism these reactions, aim present update on state-of-the-art while highlighting current challenges emerging field. The goal perspective is inspire innovation sustainable synthesis, providing chemists valuable guide.

Language: Английский

Allosteric modulation of SERCA pumps in health and disease: structural dynamics, posttranslational modifications, and therapeutic potential DOI Creative Commons
Jana Viskupičová, L. Michel Espinoza‐Fonseca

Journal of Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 169200 - 169200

Published: May 1, 2025

Language: Английский

Citations

0
Small molecule probes for peroxynitrite detection DOI Creative Commons
Aleksandra Grzelakowska, Balaraman Kalyanaraman, Jacek Zielonka

et al.

Redox Biochemistry and Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 100034 - 100034

Published: July 26, 2024

Peroxynitrite (ONOO‒/ONOOH) is a short-lived but highly reactive species that formed in the diffusion-controlled reaction between nitric oxide and superoxide radical anion. It can oxidize certain biomolecules has been considered as key cellular oxidant under various pathophysiological conditions. crucial to selectively detect quantify ONOO– determine its role biological processes. In this review, we discuss approaches used ONOO‒ cell-free systems with major emphasis on small-molecule chemical probes. We review principles mechanisms responsible for formation of detectable products, plausible limitations recommend use boronate-based probes ONOO‒, they react directly rapidly ONOO–, produce minor ONOO‒‒specific kinetics mechanism have rigorously characterized. Specific experimental protocols detection cell-free, cellular, vivo using molecular are provided (as shown BOX 1, 2, 3, 4, 5, 6).

Language: Английский

Citations

2
Biocatalytic Strategies for Nitration Reactions DOI Creative Commons
Xiling Wang, Matteo Aleotti, Mélanie Hall

et al.

JACS Au, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Nitro compounds are key synthetic intermediates used as enabling tools in synthesis and found a large range of essential compounds, including pharmaceuticals, pesticides, various organic dyes. Despite recent methodological developments, the industrial preparation nitro still suffers from harsh reaction conditions, along with poor selectivity problematic environmental footprint. Although biological enzymatic methods exist, mild approaches for bionitration underexplored. Enzymes, their exquisite compatibility have potential to revolutionize way prepared. In this perspective, we systematically analyze currently available biological/enzymatic methods, oxidation an amine precursor or consisting direct oxidative nitration non-oxidative nitration. By examining both scope mechanism these reactions, aim present update on state-of-the-art while highlighting current challenges emerging field. The goal perspective is inspire innovation sustainable synthesis, providing chemists valuable guide.

Language: Английский

Citations

0