Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 8, 2024
Frozen embryo transfer (FET) is usually recommended for women with polycystic ovary syndrome (PCOS) undergoing In vitro fertilization (IVF). While there no consensus as to the optimal protocol of endometrial preparation FET. The effect gonadotropin-releasing hormone agonist (GnRH-a) pretreatment FET among PCOS remains controversial.
Language: Английский
BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 9, 2025
Language: Английский
Citations
0
BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 11, 2025
Several studies have demonstrated that pre-treatment with long-acting Gonadotropin-Releasing Hormone agonists (GnRHa) can significantly enhance the clinical pregnancy rate among recurrent implantation failure (RIF) patients. Investigations also suggested GnRHa could ameliorate and live birth rates in polycystic ovary syndrome (PCOS) But there is a dearth of research on whether yields superior outcomes for RIF patients PCOS. The retrospective study enrolled 1602 under age 40 meeting criteria at Reproductive Medicine Center Nanjing Drum Tower Hospital, who underwent frozen-thawed embryo transfer (FET) between January 2017 December 2021. All cycles were categorized into hormone replacement therapy (HRT) Group (n = 1283) GnRHa-HRT 319), contingent usage pretreatment. Primary investigated this was rate, while early miscarriage deemed as secondary outcomes. Univariate analysis multivariate logistic regression model employed to assess impact pretreatment influence re-examined PCOS non-PCOS subgroups. Additionally, an interaction performed evaluate effect relationship rate. Multiple showed had positive (aOR 1.51, 95%CI: 1.15–1.99, P 0.003). We divided population two subgroups, patients, although higher women received compared those did not, it not statistically significant 0.81–2.82, 0.195). Interaction no difference (P 0.818), indicating influenced by Our demonstrates RIF. Among without PCOS, exhibited increase following control group. However, concurrent elevation post-GnRHa Therefore, effective improving suitable requires more cautious discussion.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 27, 2025
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Previous research has highlighted potential link between PCOS and Müllerian anomalies. The present cross-sectional study aimed to evaluate the prevalence polycystic ovary morphology (PCOM) in infertile patients with uterine anomalies (septate arcuate uterine), attending Royan Research Institute Tehran, Iran, January 2021 December 2022. A total 884 who underwent 3D-hysterosonography at were included study. participants divided into two groups: 127 757 without. Data was collected from participants' medical records. results showed that frequency PCOM significantly higher (40.9%, 52 women) compared those without such (14.7%, 111 (p = 0.0001). highlights need for targeted screening within this population underscores importance integrated diagnostic approaches.
Language: Английский
Citations
0
Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)
Published: March 12, 2025
To evaluate the pregnancy and perinatal outcomes of different phenotypes polycystic ovary syndrome (PCOS) patients during frozen embryo transfer (FET) cycles. Additionally, to analyze T cell balance in endometrium PCOS explore its relationship with various phenotypes. Retrospective cohort study. A single academically affiliated reproductive medicine center. 21,074 FET cycles were included divided into two groups based on diagnosis PCOS. Patients further categorized four phenotypic groups: PCOM + HA OA, HA, OA. Endometrial biopsies from 21 26 controls obtained subsets. Pregnancy outcomes, as well subset abundance compared between women without Multiple logistic regression models employed adjust for confounding factors impacting pregnancy-related outcomes. Flow cytometry was utilized assessed. subsets including CD4+CD8−T cells, CD4−CD8+T Th1, Th2, Th17 Treg cells determined by flow cytometry. There a significantly increased incidence miscarriage, hypertensive disorders (HDP), preterm birth (PTB), even fetal malformations across women, especially those hyperandrogenic phenotype. Th1 decreased while Th2 endometrium. The unfavorable imbalance both suggest endometrial dysfunction patients,
Language: Английский
Citations
0
BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 20, 2025
Excessive fructose intake can impact pregnancy health. Additionally, Polycystic ovary syndrome (PCOS) is associated with both elevated levels and adverse outcomes. Therefore, it significant to investigate whether serum influence outcomes in patients or without PCOS. This case-control study included 270 participants (PCOS, n = 135; non-PCOS, 135). The of consecutively treated women undergoing vitro fertilization - embryo transfer treatment at the Center reproductive medicine Shengjing hospital China Medical University, from June 2020 2021, were measured. Pregnancies monitored until ultimate outcome was determined. antenatal, delivery, neonatal extracted records. In PCOS, those who experienced miscarriage had significantly higher (P 0.011). incidence increased as quartiles PCOS 0.010). There a correlation between (r 0.258, P 0.002). results multivariate logistic regression analysis remain consistent (odd ratio [OR] 10.138, 0.005). Conversely, prematurely delivered 0.001). preterm delivery < 0.311, 0.001) non-PCOS group. indicated identical (OR 18.359, 0.008). area under curve for fructose-mediated prediction 0.686, while birth individuals, 0.731. Serum are positively risk Within cohort, linked birth. Further investigation warranted comprehensively elucidate underlying mechanisms, thus enhancing our profound understanding.
Language: Английский
Citations
0
Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(16), P. 2191 - 2202
Published: Oct. 20, 2024
Introduction Infertility related to polycystic ovary syndrome (PCOS) represents a significant challenge for women of reproductive age. Over the last few years, evidence-based medicine has driven new approaches treating infertility in patients with PCOS, changing rapidly and deeply clinical practice.
Language: Английский
Citations
3
Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 8, 2024
Frozen embryo transfer (FET) is usually recommended for women with polycystic ovary syndrome (PCOS) undergoing In vitro fertilization (IVF). While there no consensus as to the optimal protocol of endometrial preparation FET. The effect gonadotropin-releasing hormone agonist (GnRH-a) pretreatment FET among PCOS remains controversial.
Language: Английский
Citations
0