Comorbidities and neurosurgical interventions in a cohort with connective tissue disorders DOI Creative Commons

Ilene S. Ruhoy,

Paolo A. Bolognese, Jared S. Rosenblum

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

Background Connective tissue disorders (CTDs) are a heterogeneous group of often presenting with variety comorbidities including musculoskeletal, autonomic, and immune dysfunction. Some CTDs such as hypermobile Ehlers-Danlos syndrome (hEDS), which is one the most common, have been associated neurological requiring surgical intervention. The frequency these in populations their subsequent requirement for neurosurgical intervention remains unclear. Methods Based on our initial experience this population, we investigated presentation rates specific interventions cohort individuals referred to institution evaluation management issues secondary diagnosed or suspected from 2014 2023. Primary diagnoses were made by referring physicians institutions based clinical standard-of-care criteria. We evaluated relationships between multivariate correlation intersection plots using UpSetR package. Results Of 759 individuals, excluded 42 incomplete data. From remaining (total cohort, N = 717), 460 (64%) hEDS, 7 CTD other than 250 lacked formal diagnosis. found that hEDS had higher certain comorbidities, Mast Cell Activation Disorder Postural Orthostatic Tachycardia Syndrome, compared without diagnosis (unaffected). total 426 (59%) Chiari I Malformation, shared significant overlap hEDS. those who elected undergo surgery ( n 612), 61% required craniocervical fusion (CCF). Notably, 404 chose intervention, which, 73% CCF instability. Conclusion In retrospective study potentially defined commonly encountered revealed rate at they

Language: Английский

Comorbidities and neurosurgical interventions in a cohort with connective tissue disorders DOI Creative Commons

Ilene S. Ruhoy,

Paolo A. Bolognese, Jared S. Rosenblum

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

Background Connective tissue disorders (CTDs) are a heterogeneous group of often presenting with variety comorbidities including musculoskeletal, autonomic, and immune dysfunction. Some CTDs such as hypermobile Ehlers-Danlos syndrome (hEDS), which is one the most common, have been associated neurological requiring surgical intervention. The frequency these in populations their subsequent requirement for neurosurgical intervention remains unclear. Methods Based on our initial experience this population, we investigated presentation rates specific interventions cohort individuals referred to institution evaluation management issues secondary diagnosed or suspected from 2014 2023. Primary diagnoses were made by referring physicians institutions based clinical standard-of-care criteria. We evaluated relationships between multivariate correlation intersection plots using UpSetR package. Results Of 759 individuals, excluded 42 incomplete data. From remaining (total cohort, N = 717), 460 (64%) hEDS, 7 CTD other than 250 lacked formal diagnosis. found that hEDS had higher certain comorbidities, Mast Cell Activation Disorder Postural Orthostatic Tachycardia Syndrome, compared without diagnosis (unaffected). total 426 (59%) Chiari I Malformation, shared significant overlap hEDS. those who elected undergo surgery ( n 612), 61% required craniocervical fusion (CCF). Notably, 404 chose intervention, which, 73% CCF instability. Conclusion In retrospective study potentially defined commonly encountered revealed rate at they

Language: Английский

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