Targeting Injectable Hydrogels: The Role of Diphenylalanine Peptide Derivative in the Gelation Dynamics of Pluronic® F127 DOI Open Access
Vasile Robert Grădinaru, Maria Bercea, Luiza Mădălina Grădinaru

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 930 - 930

Published: March 29, 2025

The fluorenyl methyl oxycarbonyl phenylalanyl-phenylalanine ester (Fmoc-Phe-Phe-Ome) was synthetized using the liquid phase synthesis strategy. This derivative separated by hydrophobic interaction chromatography, its purity analyzed RP-HPLC and it characterized mass spectrometry. extremely peptide conjugate incorporated into aqueous solutions of Pluronic® F127 at low temperatures (below 10 °C). temperature induced sol-gel transition investigated rheological measurements. A delay transition, caused presence concentrations Fmoc-Phe-Phe-Ome (up to 1%), enables better control gelation process. viscoelastic properties hybrid networks were 37 °C in different shear conditions. Pluronic/peptide systems reported herein provide promising alternatives for developing innovative injectable gels as suitable platforms cancer treatment.

Language: Английский

Targeting Injectable Hydrogels: The Role of Diphenylalanine Peptide Derivative in the Gelation Dynamics of Pluronic® F127 DOI Open Access
Vasile Robert Grădinaru, Maria Bercea, Luiza Mădălina Grădinaru

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 930 - 930

Published: March 29, 2025

The fluorenyl methyl oxycarbonyl phenylalanyl-phenylalanine ester (Fmoc-Phe-Phe-Ome) was synthetized using the liquid phase synthesis strategy. This derivative separated by hydrophobic interaction chromatography, its purity analyzed RP-HPLC and it characterized mass spectrometry. extremely peptide conjugate incorporated into aqueous solutions of Pluronic® F127 at low temperatures (below 10 °C). temperature induced sol-gel transition investigated rheological measurements. A delay transition, caused presence concentrations Fmoc-Phe-Phe-Ome (up to 1%), enables better control gelation process. viscoelastic properties hybrid networks were 37 °C in different shear conditions. Pluronic/peptide systems reported herein provide promising alternatives for developing innovative injectable gels as suitable platforms cancer treatment.

Language: Английский

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