Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Journal of the American Heart Association,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Background
Observational
studies
and
small
randomized
controlled
trials
have
suggested
the
benefits
of
early
introduction
sodium–glucose
cotransporter
2
inhibitors
(SGLT2is)
in
acute
heart
failure
(AHF).
However,
current
evidence
on
their
efficacy
safety
this
clinical
setting
remains
limited.
Methods
We
performed
a
systematic
review
meta‐analysis
to
assess
efficacy/safety
use
SGLT2is
AHF.
PUBMED/EMBASE/Cochrane
were
searched
from
inception
May
31,
2024,
for
evaluating
outcomes
SGLT2i
initiation
patients
with
Efficacy
all‐cause
death
rehospitalizations.
Safety
included
kidney
injury,
ketoacidosis,
urinary
tract
infections,
hypotension,
hypoglycemia.
Early
was
defined
as
before
or
shortly
after
discharge
(within
3
days).
A
sensitivity
analysis
conducted,
including
only
discharge.
Results
Seven
that
enrolled
2320
included.
associated
significant
reduction
(odds
ratio,
0.71
[95%
CI,
0.55–0.92;
95%
PI,
0.55–0.98])
HF
rehospitalizations
0.73
0.57–0.94;
0.58–0.93]),
even
adjusting
follow‐up
duration.
yielded
consistent
results
outcomes.
could
not
be
usefully
determined
because
low
events
rate
resulting
wide
CIs.
The
impact
diabetic
status
basically
unknown
due
number
available
investigating
population.
Conclusions
AHF
improves
rehospitalization
rates,
can
discharge,
should
offered
most
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital
Liver
transplantation
is
a
life-saving
opportunity
for
patients
with
end-stage
liver
diseases
worldwide.There
are
two
types
of
transplants,
each
its
own
challenges.Even
brain
death
can
become
donors.Both
involve
preserving
and
reconstructing
vital
connections
this
essential
organ.Advances
in
field
offer
hope
those
advanced
diseases.An
analysis
transplants
Rio
de
Janeiro
over
14
years
aims
to
correlate
current
epidemiology
outcomes.Data
from
DATASUS
January
2008
December
2022
were
reviewed,
including
admissions,
public
expenditure,
complexity,
mortality,
deaths,
length
stay,
care,
as
well
articles
Scielo,
Lilacs,
PubMed.There
1,631
costing
R$146,798,794.70,
peak
terms
both
admissions
expenditure
(R$17,410,555.36).Of
these,
237
procedures
elective
1,394
urgent,
326
the
sector,
150
private
1,155
unknown
origin,
all
considered
high
complexity.The
overall
mortality
rate
was
11.89%,
194
deaths
recorded,
highest
being
2010
(25.93%)
lowest
2020
(6.25%).Mortality
higher
(12.24%)
sector
(19.94%)
compared
urgent
(11.84%)
(14.00%),
while
origin
had
9.35%.The
average
hospital