Harnessing immunity: Immunomodulatory therapies in COVID-19 DOI Open Access
Tsvetelina Velikova, Hristo Valkov, A Aleksandrova

et al.

World Journal of Virology, Journal Year: 2024, Volume and Issue: 13(2)

Published: June 24, 2024

An overly exuberant immune response, characterized by a cytokine storm and uncontrolled inflammation, has been identified as significant driver of severe coronavirus disease 2019 (COVID-19) cases. Consequently, deciphering the intricacies dysregulation in COVID-19 is imperative to identify specific targets for intervention modulation. With these delicate dynamics mind, immunomodulatory therapies have emerged promising avenue mitigating challenges posed COVID-19. Precision manipulating pathways presents an opportunity alter host optimizing antiviral defenses while curbing deleterious inflammation. This review article comprehensively analyzes interventions managing We explore diverse approaches hyperactive response its impact, from corticosteroids non-steroidal drugs targeted biologics, including anti-viral drugs, inhibitors, JAK convalescent plasma, monoclonal antibodies (mAbs) acute respiratory syndrome 2, cell-based (

Language: Английский

Harnessing immunity: Immunomodulatory therapies in COVID-19 DOI Open Access
Tsvetelina Velikova, Hristo Valkov, A Aleksandrova

et al.

World Journal of Virology, Journal Year: 2024, Volume and Issue: 13(2)

Published: June 24, 2024

An overly exuberant immune response, characterized by a cytokine storm and uncontrolled inflammation, has been identified as significant driver of severe coronavirus disease 2019 (COVID-19) cases. Consequently, deciphering the intricacies dysregulation in COVID-19 is imperative to identify specific targets for intervention modulation. With these delicate dynamics mind, immunomodulatory therapies have emerged promising avenue mitigating challenges posed COVID-19. Precision manipulating pathways presents an opportunity alter host optimizing antiviral defenses while curbing deleterious inflammation. This review article comprehensively analyzes interventions managing We explore diverse approaches hyperactive response its impact, from corticosteroids non-steroidal drugs targeted biologics, including anti-viral drugs, inhibitors, JAK convalescent plasma, monoclonal antibodies (mAbs) acute respiratory syndrome 2, cell-based (

Language: Английский

Citations

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