Clínica e Investigación en Arteriosclerosis (English Edition), Journal Year: 2023, Volume and Issue: 35(4), P. 206 - 217
Published: July 1, 2023
Language: Английский
New England Journal of Medicine, Journal Year: 2024, Volume and Issue: 390(9), P. 830 - 841
Published: Feb. 28, 2024
Cardiac rehabilitation provides evidence-based, secondary prevention after a cardiovascular event. This review addresses the benefits of cardiac programs and current barriers to participation.
Language: Английский
Citations
43
Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 83(3), P. 444 - 465
Published: Jan. 1, 2024
Language: Английский
Citations
31
Heart Lung and Circulation, Journal Year: 2023, Volume and Issue: 32(9), P. 1035 - 1048
Published: July 27, 2023
Patients with cardiovascular disease benefit from cardiac rehabilitation, which includes structured exercise and physical activity as core components. This position statement provides pragmatic, evidence-based guidance for the assessment prescription of rehabilitation clinicians, recognising latest international guidelines, scientific evidence increasing use technology virtual delivery methods. The patient-centred aerobic exercise, resistance have been addressed, including progression safety considerations.
Language: Английский
Citations
31
JACC. Cardiovascular imaging, Journal Year: 2024, Volume and Issue: 17(9), P. 1101 - 1112
Published: July 10, 2024
Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk coronary remains a public health priority. At present, focus cardiovascular prevention relies heavily on probabilistic scoring despite no randomized controlled trials demonstrating their efficacy. The concept using imaging guide preventative therapy is not new, but has previously focused indirect measures such as carotid intima-media thickening or calcification. In recent trials, found have computed tomography (CT) angiography were more likely started and had lower rates cardiac events. This led design SCOT-HEART 2 (Scottish Computed Tomography Heart 2) trial, which aims determine whether screening with use CT clinically effective than primary therapies reduce myocardial infarction.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1996 - 1996
Published: Feb. 7, 2024
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and associated with high mortality rates. Approximately 80% of cases occur in cirrhotic livers, posing a significant challenge for appropriate therapeutic management. Adequate screening programs high-risk groups are essential early-stage detection. The extent extrahepatic spread hepatic functional reserve recognized as two influential prognostic factors. In this retrospective multicenter study, we utilized machine learning (ML) methods to analyze predictors at time diagnosis total 208 patients. eXtreme gradient boosting (XGB) method achieved highest values identifying key factors HCC diagnosis. etiology was found be variable strongly poorer prognosis. widely used Barcelona Clinic Liver Cancer (BCLC) classification our setting demonstrated superiority over TNM classification. Although alpha-fetoprotein (AFP) remains commonly biological marker, elevated levels did not correlate reduced survival. Our findings suggest need explore new biomarkers individualized management these
Language: Английский
Citations
6
Clínica e Investigación en Arteriosclerosis, Journal Year: 2025, Volume and Issue: unknown, P. 500753 - 500753
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 17, 2025
Language: Английский
Citations
0
International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: 25, P. 200385 - 200385
Published: March 6, 2025
After
an
acute
atherosclerotic
cardiovascular
event,
high-intensity
lipid-lowering
therapy
(LLT)
is
needed
to
reduce
recurrence
risk.
This
study
aimed
describe
LLT
prescription
patterns
and
LDL-C
levels
change
after
non-fatal
coronary
syndrome
(ACS)
events
determine
if
the
recommended
goals
for
were
achieved.
Retrospective
cohort
using
electronic
health
records
(EHR)
of
Unidade
Local
de
Saúde
Matosinhos
between
2015
2023.
Participants
adults
aged
40-80
years,
with
a
ACS
hospitalization
2016
2022
(index
date);
≥1
general
practice
appointment
in
three
years
before
ACS;
one-year
follow-up
post-ACS.
Sub-analyses
focused
on
gender,
age
(
Language: Английский
Citations
Journal of Lipid Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100770 - 100770
Published: March 1, 2025
Highlights•lower
circulating
inflammatory
markers
(TNF,
RANTES)
after
n-3
or
n-6
PUFA
intake•reduction
intake
also
in
MIP-1alpha,
MIP-1beta
and
MCP-1•increased
gene
expression
adipose
tissue
by
but
not
intake•increased
MCP-1
upon
treating
cultured
human
adipocytes
with
PUFA•tissue-specific
effects
of
PUFA,
a
net
systemic
anti-inflammatory
effectAbstractn-3
(e.g.,
EPA/DHA)
LA)
fatty
acids
are
suggested
to
have
opposite
on
inflammation,
results
inconsistent
direct
comparisons
lacking.
In
double-blind,
randomized
crossover
study,
females
(n=16)
males
(n=23)
aged
30–70
years
abdominal
obesity
were
supplemented
3–4g/d
EPA/DHA
(fish
oil)
15–20g/d
LA
(safflower
for
7
weeks,
9-week
washout
phase.
Cytokines
chemokines
(multiplex
assay),
acute-phase
proteins
(MALDI-TOF
mass
spectrometry),
endothelial
function
(vascular
reaction
index
(VRI)),
blood
pressure,
acid
composition
(RBCMs/serum/adipose
tissue,
GC-MS/MS)
(microarrays,
qPCR)
measured.
While
significant
differences
between
treatments
relative
change
scores
found
systolic
pressure
(n-3
vs.
n-6:
−1.81%
2.61%,
p=0.003),
no
difference
any
circulatory
markers.
However,
compared
baseline,
was
followed
reductions
TNF
(−24.9%,
p<0.001),
RANTES
(−12.1%,
MIP-1β
(−12.5%,
p=0.014),
lowered
(−18.8%,
(−7.37%,
p=0.027),
(−7.81%,
p=0.020),
(−14.2%,
p=0.010).
Adipose
showed
treatment
weight
percent
EPA
50.2%*
−1.38%,
p<0.001,
*:
within-treatment
score),
DHA
(16.0%*
-3.67%,
(−0.033
4.91%*,
p<0.001).
transcriptomics
revealed
overall
down-regulation
genes
related
processes
up-regulation
n-6,
partly
correlating
changes
These
data
point
tissue-specific
pro-inflammatory
high
intake,
effect
as
n-3.
Language: Английский
Citations
Clínica e Investigación en Arteriosclerosis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 500773 - 500773
Published: March 1, 2025
Language: Английский
Citations
Inflammatory markers after supplementation with marine n-3 or plant n-6 PUFAs: a randomized double-blind crossover study
Impact of therapeutic inertia in lipid-lowering therapy in patients at very high cardiovascular risk