Natural product–inspired bioactive alkaloids via C–C/C–N coupling reactions: Synthetic developments, current scenario, and future perspectives
Studies in natural products chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 39
Published: Jan. 1, 2025
Language: Английский
Recent asymmetric synthesis of natural products bearing an α-tertiary amine moiety via temporary chirality induction strategies
Natural Product Reports,
Journal Year:
2023,
Volume and Issue:
41(2), P. 228 - 250
Published: Oct. 17, 2023
Covering:
2013
to
2023The
α-tertiary
amine
moiety
is
a
common
structural
motif
in
natural
alkaloids
and
frequently
associated
with
intriguing
biological
activities
inherent
synthetic
challenges.
A
major
hurdle
the
total
synthesis
of
these
asymmetric
construction
moiety.
Temporary
chirality
inductions
have
been
effective
strategies
employed
address
this
issue,
particularly
product
synthesis.
The
temporary
induction
can
be
broadly
classified
into
three
categories
based
on
types
involved:
Seebach's
self-regeneration
stereocenters
(SRS),
C-to-N-to-C
transfer,
memory
(MOC).
This
review
highlights
recent
advancements
for
amine-containing
products
between
2023.
Language: Английский
Isolation and identification of active components from Grifola frondosa and its anti‐EV71 virus effect
Wenyu Xiong,
No information about this author
Xiaoqin Jiang,
No information about this author
Junqiang He
No information about this author
et al.
Journal of the Science of Food and Agriculture,
Journal Year:
2024,
Volume and Issue:
104(7), P. 4453 - 4464
Published: Feb. 7, 2024
Abstract
BACKGROUND
It
is
reported
that
anti‐enterovirus
71
(EV71)
drugs
have
some
side
effects
on
human
health.
Notably,
fungi
plays
a
crucial
role
in
promoting
health
and
anti‐virus.
Grifola
frondosa
type
of
large
medicinal
edible
fungi,
rich
active
substances.
The
present
study
aimed
to
investigate
the
anti‐EV71
effect
G.
potential
RESULTS
In
study,
water
extract
was
subjected
ethanol
precipitation
obtain
water‐extracted
supernatant
(GFWS)
.
Their
inhibitory
EV71
virus
were
studied
based
cell
model.
results
showed
GFWS
had
stronger
security
effects.
addition,
chemical
constituents
identified
by
ultra‐high
performance
liquid
chromatography‐tandem
mass
spectrometry,
which
selected
for
further
separation
purification.
Three
compounds,
N
‐butylaniline,
succinic
acid
l
‐tryptophan,
isolated
from
NMR
spectroscopy.
noteworthy
‐butylaniline
‐tryptophan
fruiting
bodies
first
time.
Our
found
has
activity,
reduced
EV71‐induced
apoptosis
significantly
inhibited
replication
process
after
adsorption.
Furthermore,
it
could
also
bind
capsid
protein
VP1
prevent
attaching
cells.
CONCLUSION
an
inhibitor
virus,
be
used
infant
nutrition
possibly
provide
new
drug
treat
hand,
foot
mouth
disease.
©
2024
Society
Chemical
Industry.
Language: Английский
Methane production from the biodegradation of lignite with different sizes by mixed fungi-methanogen microflora
Longzhen Gao,
No information about this author
Xiao Feng,
No information about this author
Yixuan Zhang
No information about this author
et al.
FEMS Microbiology Letters,
Journal Year:
2024,
Volume and Issue:
371
Published: Jan. 1, 2024
Biogenic
coalbed
methane
(CBM)
is
a
developing
clean
energy
source.
However,
it
unclear
how
the
mechanisms
of
bio-methane
production
with
different
sizes
coal.
In
this
work,
pulverized
coal
(PC)
and
lump
(LC)
were
used
for
by
mixed
fungi-methanogen
microflora.
The
lower
from
LC
was
observed.
aromatic
carbon
degraded
slightly
2.17%
in
LC,
while
11.28%
PC.
It
attributed
to
proportion
lignin-degrading
fungi,
especially
Penicillium,
which
reached
67.57%
PC
on
7th
day,
higher
than
that
11.38%
LC.
results
suggested
limited
interaction
area
led
microorganisms
hardly
utilize
aromatics.
also
accumulation
organics
fermentation
broth
Increasing
reaction
facilitating
conversion
are
means
increase
situ.
Language: Английский