On the influence of the rhodamine substituents onto the cytotoxicity of mitocanic maslinic acid rhodamine conjugates DOI Creative Commons
Marie Kozubek, Toni C. Denner,

Marc Eckert

et al.

Results in Chemistry, Journal Year: 2022, Volume and Issue: 5, P. 100708 - 100708

Published: Dec. 6, 2022

Maslinic acid was converted via a di-acetylated piperazinyl amide into rhodamine conjugates differing in their alkyl moieties. These were submitted to cytotoxicity assays employing panel of human tumor cell lines. held high but also some selectivity especially for A2780 cells. Thereby, propyl substituted conjugate showed EC50 values as low = 0.01 μM and approx. 15 times more cytotoxic the cancer cells than non-malignant fibroblasts (NIH 3 T3). Cytotoxicity obviously parallels lipophilicity residue suggests - since compounds act mitocanes an interaction with inner mitochondrial membrane.

Language: Английский

On the influence of the rhodamine substituents onto the cytotoxicity of mitocanic maslinic acid rhodamine conjugates DOI Creative Commons
Marie Kozubek, Toni C. Denner,

Marc Eckert

et al.

Results in Chemistry, Journal Year: 2022, Volume and Issue: 5, P. 100708 - 100708

Published: Dec. 6, 2022

Maslinic acid was converted via a di-acetylated piperazinyl amide into rhodamine conjugates differing in their alkyl moieties. These were submitted to cytotoxicity assays employing panel of human tumor cell lines. held high but also some selectivity especially for A2780 cells. Thereby, propyl substituted conjugate showed EC50 values as low = 0.01 μM and approx. 15 times more cytotoxic the cancer cells than non-malignant fibroblasts (NIH 3 T3). Cytotoxicity obviously parallels lipophilicity residue suggests - since compounds act mitocanes an interaction with inner mitochondrial membrane.

Language: Английский

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