ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(46)
Published: Dec. 1, 2024
Abstract
This
review
article
intends
to
explore
the
versatility
in
formation
of
pyrrole‐fused
quinone/naphthoquinone
derivatives
described
literature
from
2008
2024.
It
deals
with
multitude
paths
its
synthesis
a
variety
precursors
using
both
metal‐
and
metal‐free
catalytic
systems
their
potential
applications.
also
documented
several
bioactive
cores
accommodating
indoloquinone
analog.
Noteworthy,
mitomycin
A
acts
as
excellent
medicine
for
cancer
treatment
analog
EO‐9
is
under
clinical
trial.
Here
we
present
natural
products
zyzzyanone
A,
murrayaquinones
B
indolequinone‐based
naloxone
prodrugs
exiguamine
(NQO1)‐targeted
hypoxia
specific
activation,
antibiotic
uthamycin
analog,
indolequinone
fused
ursolic
acid
(a
triterpenoid
rich
many
Chinese
medicines),
which
vital
scaffold
preparation
novel
anticancer
agent.
Indoloquinone‐fused
medicines)
Recent
two
cyanobacterial
metabolites
Calothrixins
has
been
documented.
discusses
intermediate,
where
lymphostin
alkaloid
can
be
developed.
Lamellarin
D
product
easily
prepared
by
developed
strategy.
European Journal of Medicinal Chemistry Reports,
Journal Year:
2024,
Volume and Issue:
12, P. 100194 - 100194
Published: July 27, 2024
Cutaneous
wounds
are
a
major
healthcare
concern
affecting
millions
of
people
as
they
fail
to
heal
properly
and
can
result
in
life
threatening
conditions
high
economic
loss.
Wound
healing
is
complex,
multifaceted
process
involving
four
consequent
stages:
haemostasis,
inflammation,
proliferation,
tissue
remodelling.
These
phases
work
coordination
restore
the
integrity
damaged
skin
underlying
tissues.
1,4-Naphthoquinone
compounds
their
derivatives
have
emerged
promising
candidates
wound
management.
Herein,
natural
such
lawsone,
juglone,
shikonin,
plumbagin
along
with
been
discussed
for
potential
special
emphasis
on
structural
activity
relationships.
This
review
provides
comprehensive
discussion
chemical
reactivity,
biological
activities,
mechanisms
action
these
naphthoquinone-based
compounds,
particularly
antibacterial
properties,
which
play
crucial
role
healing.
The
highlights
importance
elucidating
structure-activity
relationships
overcome
challenges
associated
poor
solubility,
low
efficacy,
presence
inevitable
impurities
plant
extracts.
Additionally,
emphasizes
significance
developing
diverse
naphthoquinone
at
laboratory
scale
expand
repertoire
agents.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 28, 2024
Abstract
An
efficient
method
has
been
developed
for
the
preparation
of
1,4‐naphthoquinones
via
a
palladium‐catalyzed
reaction
2‐aryl‐1,3‐indandiones
with
olefins.
This
involves
tertiary
C−H
alkylation
olefins
to
produce
alcohol,
followed
by
C−C
bond
cleavage.
