Application of 2‐Azabicyclo[2.2.1]Hept‐5‐En‐3‐One (Vince Lactam) in Synthetic Organic and Medicinal Chemistry DOI Creative Commons

Melinda Nonn,

Santos Fustero, Lóránd Kiss

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: 24(9)

Published: July 15, 2024

2-Azabicyclo[2.2.1]hept-5-en-3-one (Vince lactam) is known to be a valuable building block in synthetic organic chemistry and drug research. It an important precursor access of some blockbuster antiviral drugs such as Carbovir or Abacavir well other carbocyclic neuraminidase inhibitors agents. The ring C=C bond the Vince lactam allows versatile chemical manipulations create not only functionalized γ-lactams, but also γ-amino acid derivatives with cyclopentane framework. aim current account summarize lactam, its utility application medicinal over last decade.

Language: Английский

Application of 2‐Azabicyclo[2.2.1]Hept‐5‐En‐3‐One (Vince Lactam) in Synthetic Organic and Medicinal Chemistry DOI Creative Commons

Melinda Nonn,

Santos Fustero, Lóránd Kiss

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: 24(9)

Published: July 15, 2024

2-Azabicyclo[2.2.1]hept-5-en-3-one (Vince lactam) is known to be a valuable building block in synthetic organic chemistry and drug research. It an important precursor access of some blockbuster antiviral drugs such as Carbovir or Abacavir well other carbocyclic neuraminidase inhibitors agents. The ring C=C bond the Vince lactam allows versatile chemical manipulations create not only functionalized γ-lactams, but also γ-amino acid derivatives with cyclopentane framework. aim current account summarize lactam, its utility application medicinal over last decade.

Language: Английский

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