˜Al-œMağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ, Journal Year: 2024, Volume and Issue: 0(0), P. 1 - 7

Published: Nov. 25, 2024

Background: 1,4-dioxane (DX) was first discovered in 1863 and has been made accessible for commercial purposes around the 1930s as a solvent cellulose production of plastics. Aim: The purpose this review to highlight chemistry DX well its various reported pharmacological toxicological attributes. Methods: reviewed data abstracted by using some scientific platforms, such Google Scholar, Scopus, Web Science, with no limitation publishing date. Results: Chemically, is an organic heterocyclic molecule that can be described ether found colorless liquid slightly sweet smell, akin diethyl ether. Also, old usually referred dioxane because other structural isomers (1,2- 1,3-) are seldom encountered. Given pharmacokinetic profile, quickly entirely absorbed after oral intake inhalation exposure, cutaneous route accounting substantially less absorption. main product metabolism humans rats β-hydroxy ethoxy acetic acid, which urine-eliminated metabolite. Pharmacologically, it derivatives have therapeutic benefits against cancer general hematologic malignancies particular. studied function antimicrobial prospect pathogenic microbes. Depending on dose time frame, cause two types toxicity, including acute chronic, attributes each. Conclusion: Based examined information, possible employ bioactive scaffold developing potent antitumor agents serve better therapeutics.

Language: Английский