Comparative profiling of secondary metabolites and antidiabetic properties of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) extracts DOI
Ikponmwosa Owen Evbuomwan,

Emmanuel Henry Ezenabor,

Aishat Abimbola Adeyemi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Background: Diabetes mellitus is a chronic metabolic condition which can result in severe long-term complications, and current treatments often have significant side effects. As result, there growing interest identifying novel α-amylase α-glucosidase inhibitors with improved safety profiles. Natural products emerged as promising source of such compounds. In this study, we investigated the antidiabetic potential solvent extracts phenolic compounds from Anogeissus leiocarpus (DC.) Guill. & Perr. Methods: Dried leaves stem bark were extracted using aqueous absolute ethanol, yielding ALE, ASE, ELE, ESE. We assessed their TPC, TFC, antioxidant capacity. The efficacy these HPLC-identified was evaluated through in vitro computational analyses inhibition. Results: ASE ALE demonstrated high polyphenol flavonoid content, along strong dose-dependent activity (FRAC, TAC, DPPH, NO scavenging). ASE highest inhibition, comparable to metformin (p > 0.05). Molecular docking analysis showed interactions between both α-glucosidase, binding affinities metformin. Notably, rutin exhibited scores -7.736 -7.098 kcal/mol for respectively, outperforming (-4.305 -4.094 kcal/mol). Conclusion: These findings suggest that A. its hold promise potent safer diabetes treatment.

Language: Английский

Comparative profiling of secondary metabolites and antidiabetic properties of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) extracts DOI
Ikponmwosa Owen Evbuomwan,

Emmanuel Henry Ezenabor,

Aishat Abimbola Adeyemi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Background: Diabetes mellitus is a chronic metabolic condition which can result in severe long-term complications, and current treatments often have significant side effects. As result, there growing interest identifying novel α-amylase α-glucosidase inhibitors with improved safety profiles. Natural products emerged as promising source of such compounds. In this study, we investigated the antidiabetic potential solvent extracts phenolic compounds from Anogeissus leiocarpus (DC.) Guill. & Perr. Methods: Dried leaves stem bark were extracted using aqueous absolute ethanol, yielding ALE, ASE, ELE, ESE. We assessed their TPC, TFC, antioxidant capacity. The efficacy these HPLC-identified was evaluated through in vitro computational analyses inhibition. Results: ASE ALE demonstrated high polyphenol flavonoid content, along strong dose-dependent activity (FRAC, TAC, DPPH, NO scavenging). ASE highest inhibition, comparable to metformin (p > 0.05). Molecular docking analysis showed interactions between both α-glucosidase, binding affinities metformin. Notably, rutin exhibited scores -7.736 -7.098 kcal/mol for respectively, outperforming (-4.305 -4.094 kcal/mol). Conclusion: These findings suggest that A. its hold promise potent safer diabetes treatment.

Language: Английский

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