Translational Neurodegeneration,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 23, 2024
Abstract
Ageing
is
a
crucial
risk
factor
for
Alzheimer’s
disease
(AD)
and
characterised
by
systemic
changes
in
both
intracellular
extracellular
microenvironments
that
affect
the
entire
body
instead
of
single
organ.
Understanding
specific
mechanisms
underlying
role
ageing
development
can
facilitate
treatment
ageing-related
diseases,
such
as
AD.
Signs
brain
have
been
observed
AD
patients
animal
models.
Alleviating
pathological
caused
dramatically
ameliorate
amyloid
beta-
tau-induced
neuropathological
memory
impairments,
indicating
plays
pathophysiological
process
In
this
review,
we
summarize
impact
several
age-related
factors
on
propose
preventing
promising
strategy
improving
cognitive
health.
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(8)
Published: Aug. 14, 2023
Abstract
Ferroptosis
is
a
form
of
regulated
cell
death
induced
by
iron-dependent
lipid
peroxidation,
and
it
has
been
studied
extensively
since
its
discovery
in
2012.
Induced
iron
overload
ROS
accumulation,
ferroptosis
modulated
various
cellular
metabolic
signaling
pathways.
The
GSH-GPX4
pathway,
the
FSP1-CoQ10
GCH1-BH4
DHODH-CoQH2
system
sex
hormones
suppress
ferroptosis.
Mitochondrial
metabolism
regulates
mitochondria
also
undergo
morphological
change
during
ferroptosis,
these
changes
include
increased
membrane
density
reduced
mitochondrial
cristae.
Moreover,
energy
oxidative
phosphorylation
ATP
production
rates
lead
to
decrease
glycolysis
rate.
In
addition,
excessive
stress
induces
irreversible
damage
mitochondria,
diminishing
organelle
integrity.
production,
potential,
fusion
fission,
mitophagy
function
Notably,
some
inhibitors
target
mitochondria.
major
mechanism
for
associated
with
progression
cancer.
Metastasis-prone
or
metastatic
cancer
cells
are
more
susceptible
Inducing
tumor
shows
very
promising
potential
treating
drug-resistant
cancers.
this
review,
we
present
brief
retrospect
characteristics
then
discuss
regulation
highlight
unique
role
played
cells.
Furthermore,
explain
how
functions
as
double-edged
sword
well
novel
therapies
aimed
at
selectively
manipulating
eradication.
Frontiers in Aging Neuroscience,
Journal Year:
2022,
Volume and Issue:
14
Published: March 22, 2022
Iron
plays
a
crucial
role
in
many
physiological
processes
of
the
human
body,
but
iron
is
continuously
deposited
brain
as
we
age.
Early
studies
found
overload
directly
proportional
to
cognitive
decline
Alzheimer’s
disease
(AD).
Amyloid
precursor
protein
(APP)
and
tau
protein,
both
which
are
related
AD
pathogenesis,
associated
with
metabolism.
A
variety
metabolism-related
proteins
have
been
be
abnormally
expressed
brains
patients
mouse
models,
resulting
deposition
promoting
progression.
β
(Aβ)
hyperphosphorylated
tau,
two
pathological
hallmarks
AD,
can
also
promote
brain,
forming
vicious
cycle
development-iron
deposition.
subsequent
ferroptosis
has
potential
mechanism
underlying
neuronal
loss
neurodegenerative
diseases.
chelators,
antioxidants
hepcidin
were
useful
for
treating
represents
an
important
direction
treatment
research
drug
development
future.
The
review
explored
deep
connection
between
dysregulation
discussed
new
hypothesis
dyshomeostasis
ferroptosis,
summarized
therapeutics
capable
targeting
iron,
expectation
draw
more
attention
corresponding
development.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(13)
Published: March 23, 2023
Intervertebral
disc
degeneration
(IVDD)-induced
lower
back
pain
(LBP)
is
a
common
problem
worldwide.
The
underlying
mechanism
partially
accredited
to
ferroptosis,
based
on
sequencing
analyses
of
IVDD
patients
from
the
gene
expression
omnibus
(GEO)
databases.
In
this
study,
it
shown
that
polydopamine
nanoparticles
(PDA
NPs)
inhibit
oxidative
stress-induced
ferroptosis
in
nucleus
pulposus
(NP)
cells
vitro.
PDA
NPs
scavenge
reactive
oxygen
species
(ROS),
chelate
Fe
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(24)
Published: June 21, 2023
Emerging
evidence
suggests
that
ferroptosis,
a
unique
regulated
cell
death
modality
is
morphologically
and
mechanistically
different
from
other
forms
of
death,
plays
vital
role
in
the
pathophysiological
process
neurodegenerative
diseases,
strokes.
Accumulating
supports
ferroptosis
as
critical
factor
diseases
strokes,
pharmacological
inhibition
therapeutic
target
for
these
diseases.
In
this
review
article,
core
mechanisms
are
overviewed
roles
strokes
described.
Finally,
emerging
findings
treating
through
This
demonstrates
by
bioactive
small-molecule
compounds
(ferroptosis
inhibitors)
could
be
effective
treatments
highlights
potential
promising
avenue
used
to
prevent
article
will
shed
light
on
developing
novel
regimens
slow
down
progression
future.
Cell Death and Disease,
Journal Year:
2022,
Volume and Issue:
13(11)
Published: Nov. 5, 2022
Abstract
The
term
ferroptosis
was
put
forward
in
2012
and
has
been
researched
exponentially
over
the
past
few
years.
Ferroptosis
is
an
unconventional
pattern
of
iron-dependent
programmed
cell
death,
which
belongs
to
a
type
necrosis
distinguished
from
apoptosis
autophagy.
Actuated
by
phospholipid
peroxidation,
modulated
various
cellular
metabolic
signaling
pathways,
including
amino
acid,
lipid,
iron,
mitochondrial
metabolism.
Notably,
associated
with
numerous
diseases
plays
double-edged
sword
role.
Particularly,
metastasis-prone
or
highly-mutated
tumor
cells
are
sensitive
ferroptosis.
Hence,
inducing
prohibiting
vastly
promising
potential
treating
drug-resistant
cancers.
Immunotolerant
cancer
not
traditional
death
pathway
such
as
necroptosis,
while
crucial
role
mediating
immune
antagonize
tolerance,
broad
prospects
clinical
setting.
Herein,
we
summarized
mechanisms
delineated
regulatory
network
ferroptosis,
emphasized
its
dual
proposed
significant
benefits
microenvironment,
ultimately
presented
some
provocative
doubts.
This
review
aims
provide
practical
guidelines
research
directions
for
practice
immune-resistant
tumors.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 14
Published: July 22, 2022
With
the
acceleration
of
population
aging,
nervous
system
diseases
including
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
Huntington’s
(HD),
anxiety,
depression,
stroke,
and
traumatic
brain
injury
(TBI)
have
become
a
huge
burden
on
families
society.
The
mechanism
neurological
disorders
is
complex,
which
also
lacks
effective
treatment,
so
relevant
research
required
to
solve
these
problems
urgently.
Given
that
oxidative
stress-induced
lipid
peroxidation
eventually
leads
ferroptosis,
both
stress
ferroptosis
are
important
mechanisms
causing
disorders,
targeting
mediators
hot
direction
at
present.
Our
review
provides
current
view
underlying
participate
in
potential
application
molecular
disorders.
target
or
agents
associated
with
such
as
reactive
oxygen
species
(ROS),
nuclear
factor
erythroid
2–related
factor-antioxidant
response
element
(Nrf2-ARE),
n-acetylcysteine
(NAC),
Fe2+,
NADPH,
its
oxidases
NOX,
has
been
described
this
article.
plays
pivotal
role
further
caused
by
will
help
provide
new
targets
for
treatment
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 5, 2022
Sepsis
is
a
common
critical
illness
in
the
Intensive
care
unit(ICU)
and
its
management
treatment
has
always
been
major
challenge
medicine.
The
dysregulated
host
response
to
infection,
causing
systemic
multi-organ
multi-system
damage
main
pathogenesis.
Notably,
intense
stress
during
sepsis
can
lead
metabolic
disturbances
of
ions,
lipids
energy
organism.
Ferroptosis
an
iron-dependent,
non-apoptotic
cell
death
distinguished
by
disruption
iron
metabolism
iron-dependent
accumulation
lipid
peroxides.
Mounting
researches
have
established
that
ferroptosis
essential
part
anti-inflammatory
sepsis,
drugs
targeting
ferroptosis-related
molecules,
such
as
inhibitors,
are
gradually
proving
their
effectiveness
sepsis.
This
paper
summarizes
reviews
pathogenesis
ferroptosis,
regulatory
network,
vital
involvement
initiation
related
organ
damage,
finally
discusses
possible
target
provided
above
mechanisms,
describes
dilemmas
well
outlook,
hope
finding
more
links
between
providing
new
perspectives
for
future
Redox Biology,
Journal Year:
2023,
Volume and Issue:
62, P. 102707 - 102707
Published: April 20, 2023
Increasing
studies
have
reported
that
intervertebral
disc
degeneration
(IVDD)
is
the
main
contributor
and
independent
risk
factor
for
low
back
pain
(LBP),
it
would
be,
therefore,
enlightening
investigating
exact
pathogenesis
of
IVDD
developing
target-specific
molecular
drugs
in
future.
Ferroptosis
a
new
form
programmed
cell
death
characterized
by
glutathione
(GSH)
depletion,
inactivation
regulatory
core
antioxidant
system
(glutathione
system)
GPX4.
The
close
relationship
oxidative
stress
ferroptosis
has
been
studied
various
diseases,
but
crosstalk
between
not
explored
IVDD.
At
beginning
current
study,
we
proved
Sirt3
decreases
occurs
after
Next,
found
knockout
(Sirt3-/-)
promoted
poor
pain-related
behavioral
scores
via
increasing
stress-induced
ferroptosis.
(immunoprecipitation
coupled
with
mass
spectrometry)
IP/MS
co-IP
demonstrated
USP11
was
identified
to
stabilize
directly
binding
deubiquitinating
Sirt3.
Overexpression
significantly
ameliorate
ferroptosis,
thus
relieving
Moreover,
vivo
(USP11-/-)
resulted
exacerbated
scores,
which
could
be
reversed
overexpression
disc.
In
conclusion,
study
emphasized
importance
interaction
pathological
process
regulating
USP11-mediated
as
promising
target
treating
