The protective role of baicalin regulation of autophagy in cancers DOI Creative Commons
Qí Zhāng,

Shiyun Guo,

Han Ge

et al.

Cytotechnology, Journal Year: 2025, Volume and Issue: 77(1)

Published: Jan. 3, 2025

Language: Английский

Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage DOI Creative Commons

Hanxiao Chang,

Zheng Li, Weiwei Zhang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 2, 2024

Abstract Primary subarachnoid hemorrhage (SAH) is a type of acute stroke, accounting for approximately 10% cases, with high disability and mortality rate. Early brain injury (EBI) critical factor in determining SAH mortality; however, there are no effective treatment interventions EBI. Based on our results, the transmission cyclic GMP-AMP (cGAMP) from neurons to microglia key molecular event that triggers I interferon response, amplifies neuroinflammation, leads neuronal apoptosis. Abnormal intracytoplasmic mitochondrial DNA (mtDNA) initiating cGAS-cGAMP-STING signaling axis. Overall, axis closely associated neuroinflammation after hemorrhage. Targeting cGAS triggered by cytoplasmic mtDNA may be useful comprehensive clinical patients SAH. Further studies targeting cGAS-specific antagonists treating warranted.

Language: Английский

Citations

11
Advances in crosstalk among innate immune pathways activated by mitochondrial DNA DOI Creative Commons

Guangwei Tao,

Wenyan Liao,

Jiafeng Hou

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(1), P. e24029 - e24029

Published: Jan. 1, 2024

Mitochondria are not only the power plant for intracellular oxidative phosphorylation and ATP synthesis, but also involved in cell proliferation, differentiation, signaling apoptosis. Recent studies have shown that mitochondria play an important role other pathophysiological functions addition to cellular energy metabolism. release mitochondrial DNA (mtDNA) as a damage-associated molecular pattern (DAMP) activate Toll-like receptor 9 (TLR9), NOD-, LRR-, pyrin domain-containing 3 (NLRP3) inflammasome cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune pathways against foreign pathogenic microorganisms. The response promotes antimicrobial defense regulates antiviral signaling, their overactivation induces onset progression inflammatory diseases. In this paper, we review mtDNA activation crosstalk among activated by mtDNA, providing clues study diseases caused cytoplasmic translocation.

Language: Английский

Citations

11
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2 DOI

Fanle Zeng,

Yuan Zhang, Zhonghao Wang

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(8), P. 1660 - 1672

Published: April 8, 2024

Language: Английский

Citations

11
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice DOI

Yelong Ji,

Yuanyuan Ma,

Yimei Ma

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(4), P. 641 - 654

Published: Feb. 27, 2024

Language: Английский

Citations

10
The protective role of baicalin regulation of autophagy in cancers DOI Creative Commons
Qí Zhāng,

Shiyun Guo,

Han Ge

et al.

Cytotechnology, Journal Year: 2025, Volume and Issue: 77(1)

Published: Jan. 3, 2025

Language: Английский

Citations

1