Revista Científica de la Facultad de Ciencias Veterinarias,
Journal Year:
2025,
Volume and Issue:
35(2), P. 9 - 9
Published: April 21, 2025
In
this
study,
the
potential
therapeutic
effect
of
Maca
root
(Lepidium
Meyenii)
on
oxidative
damage
and
histopathological
changes
in
ovaries
induced
by
experimental
polycystic
ovary
syndrome
(PCOS)
rats
was
evaluated.
The
study
involved
thirty–five
female
Sprague
Dawley
rats,
each
aged
2.5
months.
These
were
allocated
into
five
distinct
groups.
first
group
did
not
receive
any
treatment
or
intervention.
Carboxymethyl
cellulose
(CMC)
(1%)
applied
to
2nd
group.
3rd
at
a
dose
2
g·kg-1·d-1
body
weight
gavage
for
7
days
(d).
1
mg·kg-1·d-1
letrozole
(PCOS
agent)
dissolved
1%
CMC
4th
21
d.
Letrozole
maca
together
5th
application
started
15th
d
d,
while
starting
14
before
both
applications
terminated
22nd
PCOS
group,
malondialdehyde
(MDA)
levels
observed
be
elevated
compared
control
whereas
reduced
glutathione
(GSH)
levels,
along
with
activities
catalase
(CAT),
peroxidase
(GSH–Px),
glutathione–S–
transferase
(GST),
superoxide
dismutase
(SOD),
found
reduced.
PCOS+maca
differences
determined
all
parameter
values
close
(except
GSH–Px
Follicle–Stimulating
Hormone
(FSH)).
number
atretic
follicles
significantly
decreased
(P≤0.01).
It
noted
that
cystic
increased
statistically
groups
other
(P≤0.001).
development
PCOS–related
ovarian
toxicity
stress,
may
contribute
discrepancy
between
oxidants
antioxidants,
help
alleviate
severe
side
effects
caused
PCOS.
European Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
286, P. 117270 - 117270
Published: Jan. 13, 2025
Organophosphorus
compounds,
characterized
by
the
incorporation
of
phosphorus
into
organic
molecules,
play
a
critical
role
in
various
fields
such
as
medicine,
agriculture,
and
industry.
Their
unique
electronic
properties
versatility
make
them
essential
developing
therapeutic
agents,
pesticides,
materials.
One
prominent
class
organophosphorus
compounds
is
heterocycles,
which
combine
benefits
both
cyclic
structures.
Triazoles,
nitrogen-containing
heterocyclic
are
particularly
notable
for
their
broad
biological
activities,
including
anticancer,
antiviral,
antibacterial,
antioxidant
effects.
Traditional
methods
synthesizing
triazoles
often
encounter
challenges
low
yields
non-selective
products,
whereas
click
chemistry
provides
more
efficient
reliable
alternative.
The
copper-catalyzed
azide-alkyne
[3
+
2]
cycloaddition,
cornerstone
chemistry,
allows
rapid
selective
formation
under
mild
conditions.
When
functionalized
with
groups,
not
only
retain
but
enhance
improving
potency,
selectivity,
stability.
This
review
covers
synthesis
organophosphorus-functionalized
via
explores
molecular
structure,
coordination
these
compounds.
behavior
interactions
derivatives
metal
ions
also
addressed,
significantly
influence
chemical
reactivity,
stability,
bioactivity.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(4)
Published: Feb. 28, 2024
Stingless
bees
belong
to
the
Meliponini
tribe
and
are
widely
distributed
in
tropics
subtropics,
where
they
perform
important
ecological
services.
Among
best
groups
of
stingless
is
genus
Scaptotrigona,
which
includes
22
species
throughout
neotropical
region,
including
area
from
Mexico
Argentina.
Bees
this
responsible
for
production
products
such
as
honey,
propolis,
geopropolis
fermented
pollen
("saburá").
This
review
aimed
provide
an
overview
chemical
composition
biological
activities
associated
with
derived
Scaptotrigona.
The
bibliographic
was
carried
out
through
searches
Scopus,
Web
Science,
ScienceDirect
PubMed
databases,
publications
2003
January
2023.
study
chemodiversity
Scaptotrigona
demonstrated
mainly
presence
flavonoids,
phenolic
acids,
terpenoids
alkaloids.
It
also
that
exhibit
a
wide
range
effects,
antibacterial,
antioxidant,
anti-inflammatory
antifungal
activities,
among
other
bioactivities.
provides
phytochemical
pharmacological
investigations
However,
it
essential
clarify
toxicity
food
safety
these
products.
Aging and Health Research,
Journal Year:
2023,
Volume and Issue:
3(4), P. 100169 - 100169
Published: Nov. 8, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
with
reduced
cognitive
function
due
to
mitochondrial
dysfunction
and
oxidative
stress.
Recent
studies
show
that
the
pathophysiology
of
AD
may
be
influenced
by
dysfunctionality,
Ca2+
imbalance,
apoptosis,
decreased
energy,
alteration
in
its
metabolism.
Study
indicates
damaged
mitochondria
play
critical
roles
pathogenesis
AD,
even
if
precise
mechanism
behind
remains
unknown.
It
thought
healthy
pool
protects
neurons
reducing
damage
caused
also
promotes
neuronal
activity
giving
enough
energy
other
associated
functions.
In
this
sense,
investigation
mechanisms
altered
constitutes
novel,
promising
therapeutic
targets
for
disease.
Mitochondria
enhances
generation,
antioxidants
scavenge
reactive
oxygen
species
reduce
substrate
supply,
glucose
metabolism,
potential
drug
candidates
target
apoptotic
mitophagy
pathways
remove
mitochondria.
Although
therapy
approaches
have
shown
promise
preclinical
studies,
there
hasn't
been
much
advancement
clinical
trials
thus
far.
Therefore,
we
try
find
out
role
highlight
development
compounds
as
AD.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(7), P. 1398 - 1398
Published: July 7, 2023
Altered
levels
of
heavy
metals
and
essential
elements
have
been
associated
with
oxidative
stress
(OS)
metabolic
hormonal
changes
in
women
polycystic
ovary
syndrome
(PCOS).
We
aimed
to
summarize
the
knowledge
on
association
OS
PCOS.
An
electronic
literature
search
using
PubMed
for
studies
published
between
January
2008
April
2023
was
conducted.
evaluated
relation
PCOS
15
articles.
had
increased
antimonium
(Sb),
cadmium
(Cd),
lead
(Pb),
mercury
(Hg),
arsenic
(As),
tellurium
(Te),
thallium
(Tl)
osmium
(Os)
blood
decreased
zinc
(Zn)
levels;
results
copper
(Cu)
were
conflicting.
Some
showed
a
significant
correlation
(Sb,
Cd,
Pb,
Hg,
As,
Te
Tl)
(Se,
Zn,
Cr,
Ca,
Mg
Cu)
markers
chronic
inflammation.
Heavy
Pb
Hg)
(Zn,
Se,
characteristics
There
might
be
possible
benefit
from
supplementation
therapy
reducing
endocrinological
problems
related
Our
review
confirmed
an
women.
This
systematic
is
registered
PROSPERO
under
number
CRD42023418453.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 14, 2024
Mitochondria
are
crucial
organelles
responsible
for
energy
generation
in
eukaryotic
cells.
Oxidative
stress,
calcium
disorders,
and
mitochondrial
DNA
abnormalities
can
all
cause
dysfunction.
It
is
now
well
documented
that
dysfunction
significantly
contributes
to
the
pathogenesis
of
numerous
illnesses.
Hence,
it
vital
investigate
innovative
treatment
methods
targeting
Extracellular
vesicles
(EVs)
cell-derived
nanovesicles
serve
as
intercellular
messengers
classified
into
small
EVs
(sEVs,
<
200
nm)
large
(lEVs,
>
based
on
their
sizes.
worth
noting
certain
subtypes
rich
components
(even
structurally
intact
mitochondria)
possess
ability
transfer
them
or
other
contents
including
proteins
nucleic
acids
recipient
cells
modulate
function.
Specifically,
target
cell
homeostasis
mitochondria-controlled
apoptosis
ROS
by
delivering
relevant
substances.
In
addition,
artificial
modification
delivery
carriers
therapeutic
goods
mitochondria
also
a
current
research
hotspot.
this
article,
we
will
focus
function
cells,
aiming
offer
novel
perspectives
approaches
diverse
conditions
linked
