Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 10, 2025
The
literature
on
the
role
of
pleomorphic
adenoma
gene
1
(PLAG1)
in
malignant
tumors
is
limited.
This
study
aimed
to
perform
pan-cancer
analysis
PLAG1.
expression
PLAG1
was
analyzed
by
Human
Protein
Atlas
(HPA).
differential
and
prognosis
were
based
TCGA
data.
relationship
between
tumor
heterogeneity,
stemness
immune
infiltration
investigated.
enrichment
biological
function
bladder
cancer
analyzed.
increased
a
variety
significantly
correlated
with
patients.
Their
levels
associated
key
checkpoint
genes
(CD274,
HAVCR2),
stimulation
factors
(CD48,
CD27).
In
cancer,
functional
indicated
that
involved
epidermal
related
processes
pathways.
reduction
can
inhibit
proliferation
cells.
has
potential
be
prognostic
marker
therapeutic
target
for
patients
tumors.
Cell Death and Disease,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 18, 2025
Abstract
Radioresistance
is
a
major
challenge
in
tumor
radiotherapy
and
involves
mixture
of
cellular
events,
including
ferroptosis,
new
type
programmed
cell
death
characterized
by
the
excess
accumulation
iron-dependent
lipid
peroxides.
In
present
study,
we
observed
that
surviving
cancer
tissues
cells
after
had
significantly
greater
glutathione
to
oxidized
(GSH/GSSG)
ratios
lower
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA)
levels
than
nonirradiated
tumors
cells.
Untargeted
lipidomic
analyses
revealed
oleic
acid
(OA)
palmitoleic
(POA)
were
most
upregulated
unsaturated
fatty
acids
irradiated
compared
with
those
control
IR.
Both
OA
POA
could
protect
from
killing
effects
ferroptosis
inducer
erastin
RSL3,
stronger
protective
effect
POA,
resulting
ROS
production
POA.
Mechanistically,
protected
caused
polyunsaturated
acid-containing
phospholipids
an
ACSL3-dependent
manner.
A
mouse
model
demonstrated
ACSL3
knockdown
combined
imidazole
ketone
synergistically
enhanced
antitumor
radiation-resistant
vivo.
Our
study
reveals
previously
undiscovered
associations
between
radiation
metabolism
providing
novel
treatment
strategy
for
overcoming
radioresistance.
Journal of physiological investigation.,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
Our
previous
research
has
established
that
hydrogen
sulfide
(H
2
S)
exerts
an
antagonistic
effect
against
the
hippocampal
neurotoxicity
induced
by
Rotenone
(ROT).
However,
underlying
mechanisms
are
so
far
poorly
understood.
Substantial
evidence
corroborates
involvement
of
ferroptosis
in
ROT-induced
neurotoxicity.
To
elucidate
protective
mechanism
H
S
neurotoxicity,
this
study
explores
its
regulatory
role
and
mechanisms.
We
used
Fluoro-Jade
B
staining
to
detect
dead
neurons.
The
levels
ferrous
ions
glutathione
(GSH)
were
measured
a
kit.
ferroptosis-related
proteins,
including
light-chain
subunit
(xCT),
GSH
peroxidase
4(GPX4),
marker
acyl-CoA
synthetase
long-chain
family
member
4(ACSL4),
ferritinophagy-related
protein,
ferritin
heavy
chain
1
(FTH1),
sequestosome
(p62),
ferritinophagy
markers
autophagosome
I/II
(LC3I/II),
nuclear
receptor
coactivator
4
(NCOA4),
Western
blot.
findings
indicate
reduces
neuron
deaths
ROT-exposed
rats.
Meanwhile,
reverses
downregulations
xCT
GPX4,
upregulations
ion
ACSL4
hippocampus
ROT.
Furthermore,
LC3I/II
NCOA4,
P62
FTH1.
Based
on
these
findings,
we
concluded
neuronal
death
involves
inhibiting
triggered
ferritinophagy.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(4)
Published: April 1, 2025
Cancer
is
the
main
leading
cause
of
death
worldwide
and
poses
a
great
threat
to
human
life
health.
Although
pharmacological
treatment
with
chemotherapy
immunotherapy
therapeutic
strategy
for
cancer
patients,
there
are
still
many
shortcomings
during
such
as
incomplete
killing
cells
development
drug
resistance.
Emerging
evidence
indicates
promise
inducing
ferroptosis
treatment,
particularly
eliminating
aggressive
malignancies
that
resistant
conventional
therapies.
This
review
covers
recent
advances
in
important
regulatory
targets
metabolic
pathway
inducers
(focusing
mainly
on
last
3
years)
delineate
their
design,
mechanisms
action,
anticancer
applications.
To
date,
compounds,
including
inhibitors,
degraders,
active
molecules
from
traditional
Chinese
medicine,
have
been
demonstrated
ferroptosis-inducing
activity
by
targeting
different
biomolecules
pathway.
However,
strictly
defined
not
yet
approved
clinical
use;
therefore,
discovery
new
highly
active,
less
toxic,
selective
compounds
remains
goal
further
research
coming
years.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 10, 2025
The
literature
on
the
role
of
pleomorphic
adenoma
gene
1
(PLAG1)
in
malignant
tumors
is
limited.
This
study
aimed
to
perform
pan-cancer
analysis
PLAG1.
expression
PLAG1
was
analyzed
by
Human
Protein
Atlas
(HPA).
differential
and
prognosis
were
based
TCGA
data.
relationship
between
tumor
heterogeneity,
stemness
immune
infiltration
investigated.
enrichment
biological
function
bladder
cancer
analyzed.
increased
a
variety
significantly
correlated
with
patients.
Their
levels
associated
key
checkpoint
genes
(CD274,
HAVCR2),
stimulation
factors
(CD48,
CD27).
In
cancer,
functional
indicated
that
involved
epidermal
related
processes
pathways.
reduction
can
inhibit
proliferation
cells.
has
potential
be
prognostic
marker
therapeutic
target
for
patients
tumors.
