Mechanisms and treatments of methamphetamine and HIV-1 co-induced neurotoxicity: a systematic review DOI Creative Commons
Lin Miao,

Haowei Wang,

Yi Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 19, 2024

Combination antiretroviral therapy (cART) has dramatically reduced mortality in people with human immunodeficiency virus (HIV), but it does not completely eradicate the from brain. Patients long-term HIV-1 infection often show neurocognitive impairment, which severely affects quality of life those infected. Methamphetamine (METH) users are at a significantly higher risk contracting through behaviors such as engaging high-risk sex or sharing needles, can lead to transmission virus. In addition, HIV-1-infected individuals who abuse METH exhibit viral loads and more severe cognitive dysfunction, suggesting that exacerbates neurotoxicity associated HIV-1. Therefore, this review focuses on various mechanisms underlying co-induced existing interventions targeting sigma 1 receptor, dopamine transporter protein, other relevant targets explored. The findings envisaged systematically establish theoretical framework for neurotoxicity, suggest novel clinical treatment targets.

Language: Английский

Natural products and ferroptosis: A novel approach for heart failure management DOI
Zeyu Zhang, Zhihua Yang, Shuai Wang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156783 - 156783

Published: April 18, 2025

Language: Английский

Citations

0
Role of lncRNA Xist-miR-124-CCL2 axis in HIV Tat-mediated microglial activation and neuroinflammation DOI Creative Commons
Palsamy Periyasamy, Seema Singh, Abiola Oladapo

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Introduction HIV proteins, such as the Transactivator of transcription (Tat), mediate neuroinflammation in central nervous system by promoting release pro-inflammatory cytokines and chemokines. Long noncoding RNAs (lncRNAs) regulate gene expression sponging microRNAs (miRs), but their role Tat-mediated microglial activation remains poorly understood. This study aimed to investigate involvement lncRNA Xist–miR-124–CCL2 axis Tat-exposed cells. Methods Mouse primary cells were exposed Tat, Xist, miR-124, CCL2 was evaluated using qPCR, Western blotting, ELISA. Dual-luciferase reporter Argonaute immunoprecipitation assays used confirm molecular interactions. Functional experiments involved Xist silencing miR-124 overexpression. In vivo validation performed doxycycline-inducible Tat transgenic mice. Results significantly upregulated downregulated mouse identified a direct target 3′-UTR CCL2. Silencing or overexpressing reduced Tat-induced activation. studies corroborated these findings, with doxycycline-fed iTat mice showing elevated levels frontal cortex. Discussion Our findings identify novel regulatory whereby upregulation sponges leading overexpression Targeting pathway may represent promising therapeutic strategy mitigate associated NeuroHIV.

Language: Английский

Citations

0
Molecular Mechanisms of Ferroptosis and Its Role in Viral Pathogenesis DOI Creative Commons

Ri-Wei Huang,

Jiang Wu, Yaodan Ma

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(12), P. 2373 - 2373

Published: Dec. 1, 2023

Ferroptosis is a novelty form of regulated cell death, and it mainly characterized by iron accumulation lipid peroxidation in the cells. Its underlying mechanism related to amino acid, iron, metabolisms. During viral infection, pathogenic microorganisms have evolved interfere with ferroptosis, ferroptosis often manipulated viruses regulate host servicing for reproduction. Therefore, this review provides comprehensive overview mechanisms elucidates intricate signaling pathways involved, explores pivotal role pathogenesis infections. By enhancing our understanding novel therapeutic strategies can be devised effectively prevent treat diseases associated process. Furthermore, unraveling developmental through which infections exploit will facilitate development innovative antiviral agents.

Language: Английский

Citations

8
Neurodevelopmental toxicity of a ubiquitous disinfection by-product, bromoacetic acid, in Zebrafish (Danio rerio) DOI
Qi Tang,

Bixi Zhao,

Siqi Cao

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135211 - 135211

Published: July 15, 2024

Language: Английский

Citations

3
Mechanisms and treatments of methamphetamine and HIV-1 co-induced neurotoxicity: a systematic review DOI Creative Commons
Lin Miao,

Haowei Wang,

Yi Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 19, 2024

Combination antiretroviral therapy (cART) has dramatically reduced mortality in people with human immunodeficiency virus (HIV), but it does not completely eradicate the from brain. Patients long-term HIV-1 infection often show neurocognitive impairment, which severely affects quality of life those infected. Methamphetamine (METH) users are at a significantly higher risk contracting through behaviors such as engaging high-risk sex or sharing needles, can lead to transmission virus. In addition, HIV-1-infected individuals who abuse METH exhibit viral loads and more severe cognitive dysfunction, suggesting that exacerbates neurotoxicity associated HIV-1. Therefore, this review focuses on various mechanisms underlying co-induced existing interventions targeting sigma 1 receptor, dopamine transporter protein, other relevant targets explored. The findings envisaged systematically establish theoretical framework for neurotoxicity, suggest novel clinical treatment targets.

Language: Английский

Citations

3