Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 16, 2025
Background
The
bioactive
compound
2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione
(DMDD),
derived
from
the
horn
root
of
star
fruit,
exhibits
therapeutic
promise
through
its
modulation
TGF-β1
pathway
and
regulation
bile
acids.
Methods
In
this
study,
a
liver
fibrosis
model
was
established
in
Kunming
mice
(KM)
induced
by
carbon
tetrachloride
(CCL4),
DMDD
(50
mg/kg)
administered
intragastrically.
HE
staining,
Masson
Sirius
staining
were
used
to
evaluate
effect
on
fibrosis.
Illumina
sequencing
platform
detect
intestinal
flora
transcriptome
information
mouse
feces,
high-performance
liquid
chromatography-tandem
mass
spectrometry
(HPLC-MS/MS)
technology
acid
content
changes
feces.
Results
results
show
that
can
mitigate
fibrosis-induced
damage
mice,
potentially
suppression
TGF-β/Smad
signaling
pathway.
Furthermore,
increased
abundance
Lactobacillus
,
Bacteroides
Ruminococcaceae
Ruminococcus
Oscillospira
thereby
addressing
disturbances
regulating
metabolism.
Conclusion
Our
study
suggests
alleviates
inhibiting
pathway,
restoring
gut
microbiota
homeostasis,
balancing
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
30, P. 101441 - 101441
Published: Jan. 1, 2025
The
therapeutic
effect
of
immune
checkpoint
inhibitors
(ICIs)
in
triple-negative
breast
cancer
(TNBC)
is
unsatisfactory.
"cold"
microenvironment
caused
by
tumor-associated
fibroblasts
(TAFs)
has
an
adverse
on
the
antitumor
response.
Therefore,
this
study,
mixed
cell
membrane-coated
porous
magnetic
nanoparticles
(PMNPs)
were
constructed
to
deliver
salvianolic
acid
B
(SAB)
induce
response,
facilitating
transition
from
a
"hot"
tumor
and
ultimately
enhancing
efficacy
inhibitors.
PMNP-SAB,
which
based
coating
red
blood
membrane
TAF
(named
PMNP-SAB@RTM),
can
simultaneously
achieve
dual
effects
"immune
escape"
"homologous
targeting".
Under
influence
external
field
(MF),
SAB
be
targeted
concentrated
at
site.
released
tumors
effectively
inhibit
production
extracellular
matrix
(ECM)
TAFs,
promote
T-cell
infiltration,
responses.
Ultimately,
combination
PMNP-SAB@RTM
BMS-1
(PD-1/PD-L1
inhibitor
1)
inhibited
growth.
Finally,
study
presents
precise
effective
new
strategy
for
TNBC
immunotherapy
basis
differentiation
microenvironments.
Ultrasonics Sonochemistry,
Journal Year:
2024,
Volume and Issue:
108, P. 106967 - 106967
Published: June 22, 2024
The
transformation
of
salvianolic
acid
B
brought
on
by
heat
treatment
recovery
ethanol
eluent,
which
is
a
difficult
problem
in
pharmaceutical
technology,
affects
the
purity
raw
material
when
medicinal
purified
resin.
Ultrasonic-assisted
nanofiltration
separation
(UANS)
was
first
employed
to
improve
efficiency
resource
utilization
regulating
rejection
and
separating
rosmarinic
from
organic
wastewater.
related
three
variables:
ultrasonic
power,
pH,
concentration.
But
there
were
differences
effects
variables
rejections
acid.
showed
decreasing
trend
with
an
increase
power
or
decrease
pH;
however,
concentration
increased
5
%
35
%,
84.96
96.60
decreased
35.09
17.51
%.
On
basis
response
surface
methodology
(RSM),
optimal
UANS
parameters
for
solution
conditions
involving
different
concentrations
are
as
follows:
10
(ultrasonic
500
W
pH
6.15),
20
6.54),
30
460
6.34).
molecular
proportions
10.75
7.13
8.27
wastewater,
while
40.52
33.83
69.87
respectively.
And
recoveries
wastewater
93.56
95.04
97.30
respectively,
3.19
2.27
0.56
proportion
correlated
exponentially.
In
comparison
conventional
(CNS),
able
resolve
conflict
between
well
enhance
recycling
prevent
pollution
environment
Experiments
using
at
intensities
suggest
that
intensity
46-50
W/L
density
0.92-1.00
W/cm
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 7, 2025
Liver
fibrosis
is
a
globally
prevalent
chronic
liver
disease,
often
representing
the
advanced
stage
of
various
conditions.
Despite
its
widespread
occurrence,
there
currently
no
widely
accepted
or
effective
treatment
for
fibrosis.
However,
increasing
evidence
supports
efficacy
Traditional
Chinese
Medicine
(TCM)
in
inhibiting
progression
In
this
study,
we
explored
effects
and
potential
mechanisms
Qizhu-Ruogan-Granules
(QZRG),
formulation
from
Affiliated
Hospital
Chengdu
University
TCM,
on
carbon
tetrachloride
(CCl4)-induced
mice.
A
total
40
male
C57BL/6J
mice
were
randomly
divided
into
five
groups
(n
=
8
per
group),
with
induced
by
injecting
10%
CCl4
15
weeks.
From
7th
week
onward,
QZRG
granules
administered
orally
to
at
low,
medium,
high
doses.
To
assess
function,
serum
levels
alanine
aminotransferase
(ALT),
aspartate
(AST),
alkaline
phosphatase
(ALP)
measured.
morphology
evaluated
using
hematoxylin-eosin
(H&E)
Masson's
trichrome
staining,
while
gene
protein
expression
analyzed
through
quantitative
reverse
transcription
polymerase
chain
reaction
(RT-PCR)
western
blot
techniques.
The
results
showed
that
significantly
reduced
AST,
ALT,
ALP
CCl4-treated
mice,
alleviated
damage,
collagen
accumulation.
Furthermore,
inhibited
apoptosis-related
proteins
BAX,
Caspase9,
Caspase8,
Caspase3,
reducing
P2Y14
fibrotic
tissues.
Additionally,
suppressed
proliferation
activated
hepatic
stellate
cells.
Our
findings
suggest
may
exert
anti-fibrotic
downregulating
effectively
slowing
Redox Biology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 103509 - 103509
Published: Jan. 1, 2025
The
activation
of
inflammatory
macrophages
plays
a
pivotal
role
in
the
development
liver
fibrosis
(LF).
Ferroptosis
contributes
to
clearance
and
release
profibrotic
factors.
Glycyrrhetic
Acid
3-O-Mono-β-d-glucuronide
(GAMG)
is
natural
compound,
potential
which
on
LF
remains
uncertain.
In
this
study,
GAMG
treatment
significantly
reduced
hepatocyte
steatosis,
fibroplasia,
cell
infiltration,
collagen
fiber
deposition
mice.
addition,
remarkably
decreased
content
protein
improved
function
indicators.
Single-cell
RNA
sequencing
revealed
that
affected
changes
macrophage
subsets
LF,
Funrich
analysis
identified
IRF1
as
key
transcription
factor
regulating
genome.
was
increased
while
ferroptosis
related
SLC7A11
down-regulated
treated
macrophages.
Mass
spectrometry
metabolomics
showed
metabolites
associated
with
LF.
vivo
vitro
experiments
further
verified
induced
through
IRF1/SLC7A11
axis,
ultimately
alleviated
Therefore,
induces
by
activating
provides
new
strategy
for
