Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 28, 2024
Non-small
cell
lung
cancer
(NSCLC),
being
the
most
prevalent
and
lethal
malignancy
affecting
lungs,
poses
a
significant
threat
to
human
health.
This
research
aims
at
illustrating
precise
role
related
mechanisms
of
silent
information
regulator
type-1
(SIRT1)
in
NSCLC
progression.
The
expression
pattern
SIRT1
lines
was
examined
using
quantitative
real-time
polymerase
chain
reaction
western
blotting.
Functional
assays
validated
biological
capabilities
on
malignant
phenotypes,
its
impact
tumorigenicity
further
evaluated
vivo.
In
addition,
FOXO1
inhibitor
AS1842856
applied
verify
FOXO
pathway
vitro.
prominently
elevated
lines.
depletion
retarded
proliferation,
migration
invasion,
while
enhancing
apoptosis
cells.
Furthermore,
silencing
restricted
tumorigenesis
Additionally,
treatment
ameliorated
inhibitory
effect
deficiency
phenotypes
deletion
exerted
an
anti-oncogenic
via
activation
FOXO1.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 265 - 265
Published: Feb. 25, 2025
Bee
pollen
(BP)
is
one
of
the
richest
known
natural
resources
micronutrients
and
bioactive
phytochemicals.
Some
captivating
bioactivities
BP
compounds,
although
being
largely
investigated
for
latter
as
individual
molecules,
remain
very
scarcely
or
completely
uninvestigated
in
bee
a
whole
product.
Among
most
intriguing
these
bioactivities,
we
identified
ferroptosis
major
one.
Ferroptosis,
recently
discovered
form
cell
death
(connecting
oxidative
stress
inflammation),
complex
pathophysiological
process
crucial
perplexing
events
current
challenging
human
diseases
such
cancer,
neurodegeneration,
general
aging
diseases.
Many
compounds
were
found
to
intricately
modulate
depending
on
cellular
context
by
inducing
this
mechanism
malignant
cells
preventing
it
non-malignant
cells.
Since
research
both
fields,
i.e.,
ferroptosis,
still
recent,
deemed
necessary
undertake
review
figure
out
extent
potential
modulating
mechanisms.
Our
proved
that
wide
range
(polyphenols,
phenolamides,
carotenoids,
vitamins,
minerals,
others)
substantially
diverse
Accordingly,
phytochemicals
nutrients
showed
interesting
preclinical
studies
lead
ferroptosis-mediated
outcomes
important
processes,
including
many
aging-related
disorders.
One
paramount
challenges
be
resolved
determine
how
different
act
biological
contexts,
either
through
synergistic
antagonistic
behaviors.
We
hope
our
work
constitutes
valuable
incentive
future
investigations
promising
relevant
avenue.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(18), P. e37613 - e37613
Published: Sept. 1, 2024
Oxaliplatin
(OXA)-based
therapy
is
effective
in
the
treatment
of
multiple
cancers.
However,
primary
or
acquired
OXA
resistance
remains
an
emerging
challenge
for
its
clinical
application.
Ferroptosis
iron-dependent
mode
cell
death
that
has
been
demonstrated
to
play
essential
role
chemoresistance
many
drugs,
including
OXA.
In
particular,
dysregulation
SLC7A11-GPX4,
one
major
antioxidant
systems
ferroptosis,
was
found
colorectal
cancer
(CRC)
and
hepatocellular
carcinoma
(HCC).
addition,
Nrf2,
upstream
regulator
GPX4
other
factors,
also
involved
CRC
HCC.
Inhibition
SLC7A11-GPX4
Nrf2
by
genetic
deletion
pharmaceutical
inhibition
could
significantly
reverse
resistance.
Long
noncoding
RNA
(lncRNA)
participates
ferroptosis
cells.
Specifically,
LINC01134
promotes
recruitment
promoter
GPX4,
thereby
exerting
transcriptional
regulation
which
eventually
increases
sensitivity
HCC
through
upregulation
ferroptosis.
On
hand,
a
novel
lncRNA
DACT3-AS1
sensitizes
gastric
cells
miR-181a-5p/sirtuin
1(SIRT1)-mediated
Therapies
based
on
combination
enhancers
provide
new
therapeutic
insights
overcome
present
review,
we
current
understanding
ferroptosis-related
resistance,
highlight
pathogenesis
chemoresistance,
summarize
available
therapies
target
enhancing
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 16, 2024
Testicular
torsion
is
a
critical
urologic
condition
for
which
testicular
detorsion
surgery
considered
irreplaceable
as
well
the
golden
method
of
reversal.
However,
surgical
treatment
equivalent
to
blood
reperfusion
process,
and
no
specific
drugs
are
available
treat
injuries.
Salidroside
(SAL)
one
main
effective
substances
in
rhodiola,
has
been
shown
have
antioxidant
antiapoptosis
activities.
This
study
was
designed
determine
whether
SAL
exerted
protective
effect
on
ischemia-reperfusion
(I/R)
injury.
In
this
study,
I/R
injury
model
testes
reoxygenation
(OGD/R)
were
used
verification,
administered
at
doses
100
mg/kg
0.05
mmol/L,
respectively.
After
experiments,
tissue
TM4
Sertoli
cells
collected
histopathologic
biochemical
analyses.
The
results
revealed
that
improves
structure
regulates
oxidation–antioxidation
system.
To
further
understand
molecular
mechanisms
treating
injuries,
transcriptomics
metabonomics
analyses
integrated.
show
Nfr2/HO-1/GPX4/ferroptosis
signaling
pathway
enriched
significantly,
indicating
it
may
be
regulatory
Thereafter,
transfection
with
Nrf2
plasmid–liposome
reverse
verify
anti-testicular
treatment.
Thus,
suggested
can
protect
against
injuries
by
regulating
Nfr2/HO-1/GPX4
inhibit
ferroptosis
potential
drug
Oncology Reviews,
Journal Year:
2024,
Volume and Issue:
18
Published: Aug. 12, 2024
Glioma
is
the
most
prevalent
primary
malignant
tumor
of
central
nervous
system.
While
traditional
treatment
modalities
such
as
surgical
resection,
radiotherapy,
and
chemotherapy
have
made
significant
advancements
in
glioma
treatment,
prognosis
for
patients
remains
often
unsatisfactory.
Ferroptosis,
a
novel
form
programmed
cell
death,
plays
crucial
role
considered
to
be
functionally
rich
death
process.
Histone
deacetylases
emerged
key
focus
regulating
ferroptosis
glioma.
By
inhibiting
activity
histone
deacetylases,
deacetylase
inhibitors
elevate
acetylation
levels
both
histones
non-histone
proteins,
thereby
influencing
various
cellular
processes.
Numerous
studies
demonstrated
that
are
implicated
development
hold
promise
its
treatment.
This
article
provides
an
overview
research
progress
on
mechanism
by
which
contribute
Reviews in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
25(10)
Published: Oct. 11, 2024
Cardiac
hypertrophy
is
characterized
by
an
increased
volume
of
individual
cardiomyocytes
rather
than
increase
in
their
number.
Myocardial
due
to
pathological
stimuli
encountered
the
heart,
which
reduces
pressure
on
ventricular
walls
maintain
cardiac
function,
known
as
hypertrophy.
This
eventually
progresses
heart
failure.
Certain
varieties
regulated
cell
death
(RCD)
pathways,
including
apoptosis,
pyroptosis,
ferroptosis,
necroptosis,
and
autophagy,
are
crucial
development
review
summarizes
molecular
mechanisms
signaling
pathways
underlying
these
RCD
focusing
mechanism
action
findings
for
It
intends
provide
new
ideas
developing
therapeutic
approaches
targeted
at
cellular
level
prevent
or
reverse
